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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 12-FEB-2025

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae ATCC 49619
  • locus tag: EL263_RS06010 [old locus tag: SPAT_1134 ]
  • pan locus tag?: PNEUPAN002470000
  • symbol: coaB
  • pan gene symbol?: coaB
  • synonym:
  • product: phosphopantothenate--cysteine ligase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: EL263_RS06010 [old locus tag: SPAT_1134 ]
  • symbol: coaB
  • product: phosphopantothenate--cysteine ligase
  • replicon: chromosome
  • strand: +
  • coordinates: 1139000..1139689
  • length: 690
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

  • Location: NZ_AP018938 (1139000..1139689) NCBI
  • BioCyc: EL263_RS06010 BioCyc
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_1088 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    ATGAAAATTTTAGTTACATCGGGCGGTACCAGTGAAGCTATCGATAGCGTCCGCTCTATC
    ACTAACCATTCTACAGGTCACTTGGGGAAAATTATCACAGAGACTTTGCTTTCTGCAGGG
    CATGAAGTTTGTTTAATTACGACAAAACGAGCTCTGAAGCCAGAGCCTCATCCTAACCTA
    AGTATTCGAGAAGTTACCAATACCAAGGACCTTCTAATAGAAATGCAAGAACGTGTTCAG
    GATTATCAGGTCTTGATCCACTCAATGGCTGTTTCTGACTACACTCCTGTTTATATGACA
    GGGCTTGAGGAAGTTCAGGCTAGCTCCAATCTAAAAGAATTTTTAAGCAAGCAGAATCAT
    CAGGCCAAGATTTCTTCAACTGATGAGGTTCAGGTTTTGTTCCTTAAAAAGACACCCAAA
    ATCATATCCCTAGTCAAGGAATGGAATCCCACTATTCATCTGATTGGTTTCAAACTGCTG
    GTTGATGTTACCGAAGATCATCTGGTTGACATTGCACGAAAAAGTCTTATCAAGAATCAA
    GCAGATTTAATCATCGCGAATGACCTGACTCAAATTTCAGCAGATCAGCACCGAGCTATA
    TTTGTTGAGAAAAATCAGCTTCAAACAGTCCAGACTAAAGAAGAAATTGCAGAACTCCTC
    CTTGAAAAAATTCAAGCCTATCATTCTTAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    690

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: EL263_RS06010 [old locus tag: SPAT_1134 ]
  • symbol: CoaB
  • description: phosphopantothenate--cysteine ligase
  • length: 229
  • theoretical pI: 6.51334
  • theoretical MW: 25724.4
  • GRAVY: -0.173362

⊟Function[edit | edit source]

  • reaction:
    EC 6.3.2.5?  ExPASy
    Phosphopantothenate--cysteine ligase (CTP) CTP + (R)-4'-phosphopantothenate + L-cysteine = CMP + diphosphate + N-((R)-4'-phosphopantothenoyl)-L-cysteine
  • TIGRFAM:
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Pantothenate and coenzyme A phosphopantothenate--cysteine ligase (TIGR02114; EC 6.3.2.5; HMM-score: 397)
    and 1 more
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Pantothenate and coenzyme A phosphopantothenoylcysteine decarboxylase / phosphopantothenate--cysteine ligase (TIGR00521; EC 4.1.1.36,6.3.2.5; HMM-score: 114.7)
  • TheSEED: data available for D39, Hungary19A-6, TIGR4
  • PFAM:
    NADP_Rossmann (CL0063) DFP; DNA / pantothenate metabolism flavoprotein (PF04127; HMM-score: 120.6)
    and 2 more
    no clan defined DUF1463; Protein of unknown function (DUF1463) (PF07316; HMM-score: 13.2)
    Cystine-knot (CL0079) Noggin; Noggin (PF05806; HMM-score: 11.8)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9975
    • Cytoplasmic Membrane Score: 0.0005
    • Cell wall & surface Score: 0.0004
    • Extracellular Score: 0.0016
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.017746
    • TAT(Tat/SPI): 0.000932
    • LIPO(Sec/SPII): 0.003718
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000699498 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MKILVTSGGTSEAIDSVRSITNHSTGHLGKIITETLLSAGHEVCLITTKRALKPEPHPNLSIREVTNTKDLLIEMQERVQDYQVLIHSMAVSDYTPVYMTGLEEVQASSNLKEFLSKQNHQAKISSTDEVQVLFLKKTPKIISLVKEWNPTIHLIGFKLLVDVTEDHLVDIARKSLIKNQADLIIANDLTQISADQHRAIFVEKNQLQTVQTKEEIAELLLEKIQAYHS

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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