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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 12-FEB-2025

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae ATCC 49619
  • locus tag: EL263_RS11195 [old locus tag: SPAT_2119 ]
  • pan locus tag?: PNEUPAN003940000
  • symbol: EL263_RS11195
  • pan gene symbol?: pipR
  • synonym:
  • product: TetR/AcrR family transcriptional regulator

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: EL263_RS11195 [old locus tag: SPAT_2119 ]
  • symbol: EL263_RS11195
  • product: TetR/AcrR family transcriptional regulator
  • replicon: chromosome
  • strand: +
  • coordinates: 2090266..2090808
  • length: 543
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NZ_AP018938 (2090266..2090808) NCBI
  • BioCyc: EL263_RS11195 BioCyc
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_2060 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    ATGCAAGAAAGTAACAAACGCTTAAAAACAAAGCGAACTATTGAAAATGCTATGGTACAA
    TTACTGATGGAACAGCCATTTGATAAAATTTCTACTGTCAAATTAGTAGAAAAAGCCGGA
    ATTAGTCGTTCCAGCTTCTATACTCACTATAAGGATAAGTATGATATGATTGAGCACTAT
    CAAAGCAAGCTATTCCATACATTTGAATATATTTTTCAAAAACATGCTCATCACAAAAGA
    GACGCTATTTTAGAAGTTTTTGAATATCTAGAGTCAGAACCACTTCTGGCTGCCCTTCTT
    TCTGAAAATGGGACTAAAGAAATCCAAAATTTCTTACGAAATAAACTTCATATCATGCTT
    AGTACAGATTTACAAAAGCGATTTATGCAACTGAATCTAAATACCACCGAATTAGAATAT
    AGTAGCATCTATCTAACTCATGCACTTTTTGGTGTCTGCCAAACTTGGATTGCACATGGA
    AAAAAAGAAAGTTCTCAAGAAATAACAGACTTCCTTATGAAAATGCTTGGTGATAAAAAT
    TGA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    543

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: EL263_RS11195 [old locus tag: SPAT_2119 ]
  • symbol: EL263_RS11195
  • description: TetR/AcrR family transcriptional regulator
  • length: 180
  • theoretical pI: 8.42889
  • theoretical MW: 21301.4
  • GRAVY: -0.503333

⊟Function[edit | edit source]

  • TIGRFAM:
    probable dihydroxyacetone kinase regulator (TIGR02366; HMM-score: 44)
    and 2 more
    Signal transduction Regulatory functions DNA interactions mycofactocin system transcriptional regulator (TIGR03968; HMM-score: 26.6)
    Metabolism Central intermediary metabolism Other phosphomevalonate kinase (TIGR01219; EC 2.7.4.2; HMM-score: 11.8)
  • TheSEED: data available for D39, Hungary19A-6, TIGR4
  • PFAM:
    TetR_C (CL0174) TetR_C_8; Transcriptional regulator C-terminal region (PF14278; HMM-score: 49.8)
    and 6 more
    HTH (CL0123) TetR_N; Bacterial regulatory proteins, tetR family (PF00440; HMM-score: 30.6)
    DUF6262; Family of unknown function (DUF6262) (PF19776; HMM-score: 23.3)
    HTH_Tnp_1_2; Helix-turn-helix of insertion element transposase (PF13022; HMM-score: 16.8)
    HAD (CL0137) HAD_2; haloacid dehalogenase-like hydrolase (PF13419; HMM-score: 16.5)
    no clan defined TMEM164; TMEM164 family (PF14808; HMM-score: 13.3)
    DUF1981; Domain of unknown function (DUF1981) (PF09324; HMM-score: 13)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:
  • genes regulated by 
    PipRTF important in Phage infection protein: in D39V
    PipR*TF important in Phage infection protein: in TIGR4

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9709
    • Cytoplasmic Membrane Score: 0.0197
    • Cell wall & surface Score: 0.0018
    • Extracellular Score: 0.0076
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.004954
    • TAT(Tat/SPI): 0.000222
    • LIPO(Sec/SPII): 0.000362
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_050123485 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MQESNKRLKTKRTIENAMVQLLMEQPFDKISTVKLVEKAGISRSSFYTHYKDKYDMIEHYQSKLFHTFEYIFQKHAHHKRDAILEVFEYLESEPLLAALLSENGTKEIQNFLRNKLHIMLSTDLQKRFMQLNLNTTELEYSSIYLTHALFGVCQTWIAHGKKESSQEITDFLMKMLGDKN

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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