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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 12-FEB-2025

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae HU-OH
  • locus tag: EL271_RS01940 [old locus tag: SPOH_0352 ]
  • pan locus tag?: PNEUPAN001251000
  • symbol: EL271_RS01940
  • pan gene symbol?: mutS2
  • synonym:
  • product: endonuclease MutS2

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: EL271_RS01940 [old locus tag: SPOH_0352 ]
  • symbol: EL271_RS01940
  • product: endonuclease MutS2
  • replicon: chromosome
  • strand: +
  • coordinates: 351256..353592
  • length: 2337
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NZ_AP018937 (351256..353592) NCBI
  • BioCyc: EL271_RS01940 BioCyc
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_0371 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    1741
    1801
    1861
    1921
    1981
    2041
    2101
    2161
    2221
    2281
    ATGAATAAGAAAATATTAGAAACATTAGAGTTCGATAAGGTCAAGGCCTTGTTTGAGCCT
    CATTTGTTGACCGAGCAGGGCTTGGAGCAATTGAGACAGCTGGCTCCGACTGCCAAAGCA
    GATAAAATCAAACAGGCTTTTGCTGAGATGAAAGAAATGCAGGCTCTTTTCGTCGAGCAA
    CCGCATTTTACTATTCTCTCAACTAAGGAAATTGCAGGAGTCTGCAAGAGGTTGGAGATG
    GGAGCGGATCTCAATATCGAGGAGTTCCTACTCTTGAAACGCGTGCTTCTTACCAGCCGA
    GAACTTCAAAGTTTTTACGCCAATCTGGAAAATGTCAGCTTGGAAGAATTAGCCCTTTGG
    TTTGAGAAATTACATGATTTTCCGCAATTACAAGGAAATCTTCAGGCCTTTAATGATGCG
    GGTTTCATTGAAAATTTTGCCAGTGAAGAATTGGCGCGAATCCGTCGAAAAATACATGAT
    AGCGAGAGTCAGGTACGCGATGTTTTACAAGACTTGCTCAAGCAAAAAGCGCAGATGTTG
    ACGGAAGGAATTGTTGCTAGCAGAAATGGCCGTCAGGTTTTACCAGTCAAAAACACCTAC
    CGCAATAAGATTGCAGGTGTCGTTCATGATATTTCTGCTAGTGGAAACACCGTCTATATC
    GAACCACGTGAGGTAGTCAAACTGAGCGAAGAAATTGCTAGTCTGCGAGCAGATGAGCGC
    TATGAAATGCTTCGCATTCTCCAAGAAATTTCTGAGCGTGTCCGCCCTCATGCGGCTGAG
    ATTGCTAATGACGCTTGGATTATCGGTCATCTGGACTTGATTCGTGCCAAGGTTCGATTT
    ATCCAAGAAAGACAAGCAGTCGTGCCTCAGCTGTCAGAAAATCAAGAGATTCAACTGCTC
    CATGTCTGCCATCCTTTGGTCAAAAATGCCGTCGCAAATGATGTCTATTTTGGTCAAGAT
    TTAACAGCTATTGTCATTACAGGTCCCAATACAGGTGGGAAGACCATCATGCTCAAAACT
    CTGGGCTTGACACAGGTCATGGCCCAGTCAGGATTGCCGATTTTAGCAGACAAGGGAAGT
    CGTGTTGGTATTTTTGAAGAAATCTTTGCTGATATTGGAGATGAGCAGTCTATTGAGCAG
    AGCTTGTCTACCTTCTCTAGCCATATGACCAATATCGTGGATATTCTTGGCAAGGTCAAC
    CAACATTCACTCTTACTTTTGGATGAGTTGGGGGCTGGTACTGATCCCCAAGAGGGAGCA
    GCCCTTGCCATGGCTATTCTGGAGGACCTTCGCCTGCGTCAAATCAAGACCATGGCGACG
    ACCCACTATCCAGAACTCAAGGCCTACGGTATTGAGACAGCCTTTGTGCAAAATGCCAGT
    ATGGAGTTTGATACTGCAACTCTTCGCCCGACCTATCGCTTTATGCAGGGTGTTCCTGGC
    CGAAGTAATGCCTTTGAAATTGCCAAACGTCTAGGCCTATCTGAAGTTATCGTAGGAGAT
    GCCAGTCAGCAGATCGATCAGGACAATGACGTCAATCGTATCATTGAGCAACTAGAAGAG
    CAGACGCTGGAAAGCCGCAAACGCTTGGACAATATCCGTGAGGTGGAGCAAGAAAATCTC
    AAGATGAACCGTGTGCTAAAAAAACTCTACAACGAGCTTAATCGTGAAAAGGAAACCGAG
    CTTAACAAGGCGCGTGAACAGGCTGCTGAGATTGTGGATATGGCCCTAAGTGAAAGTGAC
    CAGATTCTCAAAAATCTCCACAGTAAATCCCAACTCAAGCCCCACGAAATCATTGAAGCC
    AAAGCCAAGTTGAAAAAATTGGCTCCTGAAAAAGTGGACTTGTCTAAAAACAAGGTCCTT
    CAAAAGGCCAAGAAAAAACGAGCTCCAAAGGTGGGAGATGATATCGTGGTTCTCAGTTAT
    GGTCAGCGTGGTACCTTGACCAGTCAACTCAAGGACGGCCGCTGGGAAGCCCAAGTTGGC
    TTGATTAAGATGACCTTGGAAGAGAAAGAGTTTGATCTTGTTCAAGCCCAGCAAGAAAAA
    CCAGTCAAGAAGAAACAGGTCAATGTTGTGAAACGAACTTCTGGGCGAGGACCTCAAGCT
    AGACTGGATCTTCGAGGCAAGCGCTATGAAGAAGCCATGAATGAGCTAGATACCTTCATC
    GACCAAGCCTTGCTTAACAATATGGCTCAAGTTGATATCATCCATGGTATCGGAACAGGA
    GTCATCCGTGAAGGAGTTACCAAATACTTGCAAAGAAACAAACATGTCAAGAGTTTCGGC
    TATGCCCCACAAAATGCTGGAGGCAGTGGTGCGACTATTGTCACTTTTAAAGGATAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1680
    1740
    1800
    1860
    1920
    1980
    2040
    2100
    2160
    2220
    2280
    2337

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: EL271_RS01940 [old locus tag: SPOH_0352 ]
  • symbol: EL271_RS01940
  • description: endonuclease MutS2
  • length: 778
  • theoretical pI: 6.85423
  • theoretical MW: 87639
  • GRAVY: -0.373779

⊟Function[edit | edit source]

  • TIGRFAM:
    Genetic information processing DNA metabolism Other MutS2 family protein (TIGR01069; HMM-score: 677.3)
    and 1 more
    Genetic information processing DNA metabolism DNA replication, recombination, and repair DNA mismatch repair protein MutS (TIGR01070; HMM-score: 120.8)
  • TheSEED: data available for D39, Hungary19A-6, TIGR4
  • PFAM:
    P-loop_NTPase (CL0023) MutS_V; MutS domain V (PF00488; HMM-score: 114)
    and 7 more
    no clan defined Smr; Smr domain (PF01713; HMM-score: 75.4)
    SH3 (CL0010) MSSS; MutS2 and Smr-associated SH3 domain (PF20297; HMM-score: 38.8)
    P-loop_NTPase (CL0023) AAA_22; AAA domain (PF13401; HMM-score: 19.1)
    no clan defined DUF5694; Family of unknown function (DUF5694) (PF18950; HMM-score: 16)
    His_Kinase_A (CL0025) HisKA; His Kinase A (phospho-acceptor) domain (PF00512; HMM-score: 12.8)
    Peptidase_PA (CL0124) Peptidase_S29; Hepatitis C virus NS3 protease (PF02907; HMM-score: 11.5)
    no clan defined Herpes_UL6; Herpesvirus UL6 like (PF01763; HMM-score: 9.2)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9922
    • Cytoplasmic Membrane Score: 0.0037
    • Cell wall & surface Score: 0.0012
    • Extracellular Score: 0.0029
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.006446
    • TAT(Tat/SPI): 0.000413
    • LIPO(Sec/SPII): 0.000412
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_001035034 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MNKKILETLEFDKVKALFEPHLLTEQGLEQLRQLAPTAKADKIKQAFAEMKEMQALFVEQPHFTILSTKEIAGVCKRLEMGADLNIEEFLLLKRVLLTSRELQSFYANLENVSLEELALWFEKLHDFPQLQGNLQAFNDAGFIENFASEELARIRRKIHDSESQVRDVLQDLLKQKAQMLTEGIVASRNGRQVLPVKNTYRNKIAGVVHDISASGNTVYIEPREVVKLSEEIASLRADERYEMLRILQEISERVRPHAAEIANDAWIIGHLDLIRAKVRFIQERQAVVPQLSENQEIQLLHVCHPLVKNAVANDVYFGQDLTAIVITGPNTGGKTIMLKTLGLTQVMAQSGLPILADKGSRVGIFEEIFADIGDEQSIEQSLSTFSSHMTNIVDILGKVNQHSLLLLDELGAGTDPQEGAALAMAILEDLRLRQIKTMATTHYPELKAYGIETAFVQNASMEFDTATLRPTYRFMQGVPGRSNAFEIAKRLGLSEVIVGDASQQIDQDNDVNRIIEQLEEQTLESRKRLDNIREVEQENLKMNRVLKKLYNELNREKETELNKAREQAAEIVDMALSESDQILKNLHSKSQLKPHEIIEAKAKLKKLAPEKVDLSKNKVLQKAKKKRAPKVGDDIVVLSYGQRGTLTSQLKDGRWEAQVGLIKMTLEEKEFDLVQAQQEKPVKKKQVNVVKRTSGRGPQARLDLRGKRYEEAMNELDTFIDQALLNNMAQVDIIHGIGTGVIREGVTKYLQRNKHVKSFGYAPQNAGGSGATIVTFKG

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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