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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 12-FEB-2025

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae HU-OH
  • locus tag: EL271_RS04995 [old locus tag: SPOH_0923 ]
  • pan locus tag?: PNEUPAN002138000
  • symbol: EL271_RS04995
  • pan gene symbol?: leuA_1
  • synonym:
  • product: histone-lysine N-methyltransferase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: EL271_RS04995 [old locus tag: SPOH_0923 ]
  • symbol: EL271_RS04995
  • product: histone-lysine N-methyltransferase
  • replicon: chromosome
  • strand: +
  • coordinates: 923849..925033
  • length: 1185
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NZ_AP018937 (923849..925033) NCBI
  • BioCyc: EL271_RS04995 BioCyc
  • MicrobesOnline:
  • PneumoBrowse for strain D39V:

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    ATGGTAAAAATATATGAAGAAACTTTACGAGATGGTATTCAGAGTAGCGAACTTTCAATG
    TTGAATACTGAGGATAAAAAGAAAGTTATTAAGAATTTTGATAATGCTGGCATAGAAGGA
    TGTTGTATTGGTTTTATAAATTCCTCAAAAAAAGAAAATGATGAAATTAATGAATTGTTC
    CAATTTATTATTACTAATAAGCTGAAGATAGTTCCAGCAGTTTTATGTAGGTTGCTGATT
    GAGGATTTTAAAGAAATTAAAAATATCGTTCAATGCAATTTATTTAATCAACTTAAGGTA
    TACACGTATATTGCTGTCAGCCCAATAAGGATGAAAGTGGAGAATTGGAGTGAAGAAATT
    ATCATTGAGAAAATAATTGACTTTCTTAATTATTGCCAAATGGAAAATGCTAAAATAACT
    ATTGCATTTGAAGATGCTTCTAGAGCTGATAAAAGCTTTTTAAAGAAGTTAATTGAAATA
    ATAAACAATTATCCTTTGGTTAAGAGTGTCGTCATTGCTGATACTGTCGGAACTTGTAAT
    TATAATTCAACTAGAGATCTGGTATATTTTTTTAGAAAAAATTTATTTTTGAGTAAAACT
    ATTGAGTGGCATGGTCATAATGATTTAGGACTTGCTGTCTCAAACGCCTTATCTGCTATT
    GAATCGGGTGCAGATATAGTACATACTTGCACTCTAGGGATTGGAGAAAGATGTGGAAAT
    ACTTCAACAGAGCAACTGATAATTAATCTTATTGTAAGTGAGTGTGGGAGAAGAGCAACT
    TATAAACTGAGATATTTGTATGATGTTGCAAAGATTTTAGAAAATAAATCACAATTTCCA
    ATATCGCCTAAGACTCCGTGTTTTGGAATGGATTCCTTTTTCACTTGCGCAGGAACACAT
    GCATCATCACTTTATAAATCATATCTTAAAAATGATAATAATTTTTCAATCATATTTTCA
    CCATATGATTCTAATATTTTTGGTAGGGAGGTGACAGTAGGTATTAATTCTCAAAGTGGG
    AGAAGCAGTATTGAATATATAAGTCGAAAATATGGTTTAGAATTAAGTCAGGAGAATATA
    ACTTCTATATTAGGCTTAGTGAAACAAAATGACTTATTTTTTAGGGAAGAGGAATTTGTT
    GATTATGTTAAACAAAAAAGAGTGGAAAGACTTGACTATAAGTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1185

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: EL271_RS04995 [old locus tag: SPOH_0923 ]
  • symbol: EL271_RS04995
  • description: histone-lysine N-methyltransferase
  • length: 394
  • theoretical pI: 6.51651
  • theoretical MW: 45052.4
  • GRAVY: -0.161929

⊟Function[edit | edit source]

  • TIGRFAM:
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Other homocitrate synthase (TIGR02660; EC 2.3.3.14; HMM-score: 170.6)
    Metabolism Central intermediary metabolism Nitrogen fixation homocitrate synthase (TIGR02660; EC 2.3.3.14; HMM-score: 170.6)
    homocitrate synthase (TIGR02146; EC 2.3.3.14; HMM-score: 168.2)
    isopropylmalate/citramalate/homocitrate synthases (TIGR02090; HMM-score: 161.7)
    Metabolism Amino acid biosynthesis Pyruvate family 2-isopropylmalate synthase (TIGR00973; EC 2.3.3.13; HMM-score: 137)
    and 5 more
    Unknown function General citramalate synthase (TIGR00977; EC 2.3.1.182; HMM-score: 88.9)
    Metabolism Amino acid biosynthesis Pyruvate family 2-isopropylmalate synthase (TIGR00970; EC 2.3.3.13; HMM-score: 63)
    Metabolism Energy metabolism Other 4-hydroxy-2-oxovalerate aldolase (TIGR03217; EC 4.1.3.39; HMM-score: 60.2)
    Metabolism Transport and binding proteins Cations and iron carrying compounds oxaloacetate decarboxylase alpha subunit (TIGR01108; EC 4.1.1.3; HMM-score: 32.1)
    Metabolism Energy metabolism Other oxaloacetate decarboxylase alpha subunit (TIGR01108; EC 4.1.1.3; HMM-score: 32.1)
  • TheSEED:
  • PFAM:
    TIM_barrel (CL0036) HMGL-like; HMGL-like (PF00682; HMM-score: 149.9)
    and 1 more
    PF (CL0431) Sedlin_N; Sedlin, N-terminal conserved region (PF04628; HMM-score: 13.5)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9323
    • Cytoplasmic Membrane Score: 0.009
    • Cell wall & surface Score: 0.0001
    • Extracellular Score: 0.0585
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.020734
    • TAT(Tat/SPI): 0.001126
    • LIPO(Sec/SPII): 0.005934
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000239146 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MVKIYEETLRDGIQSSELSMLNTEDKKKVIKNFDNAGIEGCCIGFINSSKKENDEINELFQFIITNKLKIVPAVLCRLLIEDFKEIKNIVQCNLFNQLKVYTYIAVSPIRMKVENWSEEIIIEKIIDFLNYCQMENAKITIAFEDASRADKSFLKKLIEIINNYPLVKSVVIADTVGTCNYNSTRDLVYFFRKNLFLSKTIEWHGHNDLGLAVSNALSAIESGADIVHTCTLGIGERCGNTSTEQLIINLIVSECGRRATYKLRYLYDVAKILENKSQFPISPKTPCFGMDSFFTCAGTHASSLYKSYLKNDNNFSIIFSPYDSNIFGREVTVGINSQSGRSSIEYISRKYGLELSQENITSILGLVKQNDLFFREEEFVDYVKQKRVERLDYK

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

  • PneumoExpress for strain D39V:

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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