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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 12-FEB-2025

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae NU83127
  • locus tag: EL277_RS00375 [old locus tag: SPNU_0069 ]
  • pan locus tag?: PNEUPAN000694000
  • symbol: zmpC
  • pan gene symbol?: zmpC
  • synonym:
  • product: zinc metalloprotease ZmpC

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: EL277_RS00375 [old locus tag: SPNU_0069 ]
  • symbol: zmpC
  • product: zinc metalloprotease ZmpC
  • replicon: chromosome
  • strand: +
  • coordinates: 73223..78793
  • length: 5571
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NZ_AP018936 (73223..78793) NCBI
  • BioCyc: EL277_RS00375 BioCyc
  • MicrobesOnline:
  • PneumoBrowse for strain D39V:

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
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    841
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    1021
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    1501
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    1621
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    1981
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    5401
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    5521
    ATGAGCCGAAAAAGCATTGGTGAGAAACGCCATAGTTTCTCGATGAGAAAGTTGTCAGTG
    GGATTGGTATCAGTTACTGTATCTAGTTTCTTTTTGATGAGTCAAGGGATTCAATCGGTA
    TCGGCCGATAATATGGAAAGTCCAATTCATTATAAGTATATGACCGAGGGTAAATTGACA
    GACGAGGAAAAATCCTTGCTGGTAGAGGCCCTTCCACAACTGGCTGAAGAATCAGATGAT
    ACTTATTACTTGGTTTATAGATCTCAACAGTTTTTACCGAATACAGGTTTTAACCCAACT
    GTTGGTACTTTCCTTTTTACTGCAGGATTGAGCTTGTTAGTTTTATTGGTTTCTAAAAGG
    GAAAATGGAAAGAAACGACTTGTTCATTTTCTGCTGTTGACTAGCATGGGAGTTCAATTG
    TTGCCGGCCAGTGCTTTTGGGTTGACCAGCCAGATTTTATCTGCCTATAATAGTCAGCTT
    TCTATCGGAGTCGGGGAACATTTACCAGAGCCTCTGAAAATCGAAGGTTATCAATATATT
    GGTTATATCAAAACTAAGAAACAGGATAATACAGAGCTTTCAAGGACAGTTGATGGGAAA
    TACTCTGCTCAAAGAGATAGTCAACCAAACTCTACAAAAACATCAGATGTAGTTCATTCA
    GCTGATTTAGAATGGAACCAAGGACAGGGGAAGGTTAGTTTACAAGGTGAAGCATCAGGG
    GATGATGGACTTTCAGAAAAATCTTCTATAGCAGCAGACAATCTATCTTCTAATGATTCA
    TTCGCAAGTCAAGTTGAGCAGAATCCGGATCACAAAGGAGAATCTGTAGTTCGACCAACA
    GTGCCAGAACAAGGAAATCCTGTGTCTGCTACAACGGTGCAGAGTGCGGAAGAGGAAGTA
    TTGGCGACGACAAATGATCGACCAGAGTATAAACTTCCATTGGAAACCAAAGGCACGCAA
    GAACCCGGTCATGAGGGTGAAGCCGCAGTCCGTGAAGACTTACCAGTCTACACTAAGCCA
    CTAGAAACCAAAGGTACACAAGGACCCGGACATGAAGGTGAAGCTGCAGTTCGCGAGGAA
    GAACCAGCTTACACAGAACCGTTAGCAACGAAAGGCACGCAAGAGCCAGGTCATGAGGGC
    AAAGCTACAGTCCGCGAAGAGACTCTAGAGTACACGGAACCGGTAGCGACAAAAGGCACA
    CAAGAACCCGAACATGAGGGCGAAGCGGCAGTAGAAGAAGAACTTCCGGCTTTAGAGGTC
    ACTACACGAAATAGAACGGAAATCCAGAATATTCCTTATACAACAGAAGAAATTCAGGAT
    CCAACACTTCTGAAAAATCGTCGTAAGATTGAACGACAAGGGCAAGCAGGGACACGTACA
    ATTCAATATGAAGACTACATCGTAAATGGTAATGTCGTAGAAACTAAAGAAGTGTCACGA
    ACTGAAGTAGCTCCGGTCAACGAAGTCGTTAAAGTAGGAACACTTGTGAAAGTTAAACCT
    ACAGTAGAAATTACAAACTTAACAAAAGTTGAGAACAAAAAATCTATAACTGTAAGTTAT
    AACTTAATAGACACTACCTCAGCATATGTTTCTGCAAAAACGCAAGTTTTCCATGGAGAC
    AAGCTAGTTAAAGAGGTGGATATAGAAAATCCTGCCAAAGAGCAAGTAATATCAGGTTTA
    GATTACTACACACCGTATACAGTTAAAACACACCTAACTTATAATTTGGGTGAAAATAAT
    GAGGAAAATACTGAAACATCAACTCAAGATTTCCAATTAGAGTATAAGAAAATAGAGATT
    AAAGATATTGATTCAGTAGAATTATACGGTAAAGAAAATGATCGTTATCGTAGATATTTA
    AGTCTAAGTGAAGCGCCGACTGATACGGCTAAATACTTTGTAAAAGTGAAATCAGATCGC
    TTCAAAGAAATGTACCTACCTGTAAAATCTATTACAGAAAATACGGATGGAACGTATAAA
    GTGACGGTAGCCGTTGATCAACTTGTCGAAGAAGGTACAGACGGTTACAAAGATGATTAC
    ACATTTACTGTAGCTAAATCTAAAGCAGAGCAACCAGGAGTTTACACATCCTTTAAACAG
    CTGGTAACAGCCATGCAAAGCAATCTGTCTGGTGTCTATACATTGGCTTCAGATATGACC
    GCAGATGAGGTGAGCTTAGGCGATAAGCAGACAAGTTATCTCACAGGTGCATTTACAGGG
    AGCTTGATCGGTTCTGATGGAACAAAATCGTATGCCATTTATGATTTGAAAAAACCATTA
    TTTGATACATTAAATGGTGCTACAGTTAGAGATTTGGATATTAAAACTGTTTCTGCTGAT
    AGTAAAGAAAATGTCGCAGCGCTGGCGAAGGCAGCGAATAGCGCGAATATTAATAATGTT
    GCAGTAGAAGGAAAAATCTCAGGTGCGAAATCTGTTGCGGGATTAGTAGCGAGCGCAACA
    AATACAGTGATAGAAAACAGCTCGTTTACAGGGAAACTTATCGCAAATCACCAGGACAGT
    AATAAAAATGATACTGGAGGAATAGTAGGTAATATAACAGGAAATAGTTCGAGAGTTAAT
    AAAGTTAGGGTAGATGCCTTAATCTCTACTAATGCACGCAATAATAACCAAACAGCTGGA
    GGGATAGTAGGTAGATTAGAAAATGGTGCATTGATATCTAATTCGGTTGCTACTGGAGAA
    ATACGAAATGGTCAAGGATATTCTAGAGTCGGAGGAATAGTAGGATCTACGTGGCAAAAC
    GGTCGAGTAAATAATGTTGTGAGTAACGTAGATGTTGGAGATGGTTATGTTATCACCGGT
    GATCAATACGCAGCAGCAGATGTGAAAAATGCAAGTACATCAGTTGATAATAGAAAAGCA
    GACAGATTCGCTACAAAATTATCAAAAGACCAAATAGACGCGAAAGTTGCTGATTATGGA
    ATCACAGTAACTCTTGATGATACTGGGCAAGATTTAAAACGTAATCTAAGAGAAGTTGAT
    TATACAAGACTAAATAAAGCAGAAGCTGAAAGAAAAGTAGCTTATAGCAACATAGAAAAA
    CTGATGCCATTCTACAATAAAGACCTAGTAGTTCACTATGGTAACAAAGTAGCGACAACA
    GATAAACTTTACACTACAGAATTGTTAGATGTTGTGCCGATGAAAGATGATGAAGTAGTA
    ACGGATATTAATAATAAGAAAAATTCAATAAATAAAGTTATGTTACATTTCAAAGATAAT
    ACAGTAGAATACCTAGATGTAACATTCAAAGAAAACTTCATAAACAGTCAAGTAATCGAA
    TACAATGTTACAGGAAAAGAATATATATTCACACCAGAAGCATTTGTTTCAGACTATACA
    GCGATAACGAATAACGTACTAAGCGACTTGCAAAATGTAACACTTAACTCAGAAGCTACT
    AAAAAAGTACTAGGAGCAGCGAATGATGCAGCCTTAGATAACCTATACTTAGATAGACAA
    TTTGAAGAAGTTAAAGCTAATATAGCAGAACACCTAAGAAAAGTATTAGCGATGGATAAA
    TCAATCAATACTACAGGAGACGGTGTAGTTGAATACGTAAGTGAGAAAATCAAAAATAAC
    AAAGAAGCATTTATGCTAGGTCTTACTTATATGAACCGTTGGTACGATATTAATTATGGT
    AAAATGAATACAAAAGATTTATCTACGTACAAGTTTGACTTTAACGGAAATAATGAGACT
    TCAACGTTGGATACTATTGTCGCATTAGGAAATAGTGGACTAGATAACCTGAGAGCTTCA
    AATACTGTAGGTTTATATGCGAATAAACTTGCATCGGTAAAAGGAGAAGATTCAGTCTTT
    GACTTCGTAGAAGCGTATAGAAAACTGTTCTTACCAAACAAAACAAATAACGAGTGGTTT
    AAAGAAAATACAAAGGCATATATAGTCGAAATGAAGTCTGATATTGCAGAAGTACGAGAA
    AAACAAGAATCACCAACAGCCGATAGAAAATATTCATTAGGAGTTTACGATAGAATATCA
    GCACCAAGTTGGGGGCATAAGAGTATGTTATTACCACTACTAACTTTACCTGAAGAATCT
    GTGTATATTTCATCGAATATGTCTACACTTGCATTCGGTTCGTATGAAAGATATCGTGAT
    AGTGTGGATGGAGTTATTCTTTCAGGAGATGCTTTACGAACTTATGTAAGAAATAGAGTT
    GATATAGCAGCGAAAAGGCATAGAGACCATTATGATATTTGGTACAATCTTCTTGACAGT
    GCTTCAAAAGAAAAACTTTTCCGTTCTGTGATAGTTTATGATGGATTCAATGTAAAAGAT
    GAGACAGGAAGAACTTATTGGGCAAGGTTAACGGATAAAAACATCGGCTCTATTAAAGAA
    TTCTTCGGACCTGTTGGGAAATGGTATGAGTATAATAGTAGTGCAGGAGCGTATGCGAAT
    GGAAGTTTAACGCACTTTGTGTTAGATAGATTATTAGATGCTTATGGAACGTCGGTTTAT
    ACTCATGAAATGGTTCATAATTCTGATTCTGCAATCTACTTTGAAGGAAATGGTAGACGT
    GAAGGATTGGGAGCGGAGTTATACGCACTTGGTTTACTGCAATCTGTAGATAGTGTAAAT
    TCTCATATTTTAGCTTTAAATACGTTATATAAAGCAGAAAAAGATGATTTGAATAGATTG
    CATACATATAATCCGGTGGAACGTTTCGATTCGGATGAGGCGCTTCAAAGTTATATGCAT
    GGATCATATGATGTAATGTATACACTTGATGCGATGGAAGCAAAAGCGATATTAGCTCAA
    AATAATGATGTTAAGAAAAAATGGTTTAGAAAAATAGAAAATTATTACGTTCGTGATACT
    AGACATAATAAAGATACACATGCAGGAAATAAAGTCCGTCCATTAACAGATGAAGAAGTA
    GCTAACTTAACATCGTTAAACTCATTAATCGACAACGACATCATAAATAGACGTAGCTAT
    GATGATAATAGAGAATATAAACGAAATGGCTACTATACTATAAGTATGTTCTCTCCTGTA
    TACGCAGCGCTAAGCAATTCGAAAGGTGCTCCTGGAGATATTATGTTTAGAAAAATAGCT
    TATGAATTACTTGCGGAAAAAGGTTATCACAAAGGATTCCTACCTTATGTTTCTAATCAG
    TACGGAGCAGAAGCATTTGCCAGCGGAAGCAAAACATTCTCATCATGGCATGGAAGAGAT
    GTTGCTTTAGTGACAGATGATTTAGTATTTAAGAAAGTATTCAATGGTGAGTACTCATCA
    TGGGCTGATTTCAAAAAAGCAATGTTTAAACAACGTATAGATAAACAAGATAATCTGAAA
    CCAATAACAATTCAATACGAATTAGGTAATCCTAATAGTACAAAAGAAGTAACTATAACA
    ACGGCTGCACAAATGCAACAATTAATTAATGAAGCGGCTGCGAAAGATATTACTAATATA
    GATCGTGCAACGAGTCATACCCCAGCAAGTTGGGTGCATTTATTAAAACAAAAAATCTAT
    AATGCATATCTTCGCACTACAGATGACTTTAGAAATTCTATATATAAATAA
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⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: EL277_RS00375 [old locus tag: SPNU_0069 ]
  • symbol: ZmpC
  • description: zinc metalloprotease ZmpC
  • length: 1856
  • theoretical pI: 5.23785
  • theoretical MW: 206762
  • GRAVY: -0.547144

⊟Function[edit | edit source]

  • TIGRFAM:
    gram-positive signal peptide, YSIRK family (TIGR01168; HMM-score: 43.7)
  • TheSEED: data available for TIGR4
  • PFAM:
    no clan defined Peptidase_M26_C; M26 IgA1-specific Metallo-endopeptidase C-terminal region (PF07580; HMM-score: 827.2)
    and 5 more
    Peptidase_M26_N; M26 IgA1-specific Metallo-endopeptidase N-terminal region (PF05342; HMM-score: 300.7)
    G5 (CL0593) G5; G5 domain (PF07501; HMM-score: 56.1)
    no clan defined YSIRK_signal; YSIRK type signal peptide (PF04650; HMM-score: 25)
    Glug; The GLUG motif (PF07581; HMM-score: 21.7)
    DUF6106; Family of unknown function (DUF6106) (PF19601; HMM-score: 9)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cellwall
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 10
    • Extracellular Score: 0
    • Internal Helices: 2
  • DeepLocPro: Cell wall & surface
    • Cytoplasmic Score: 0.0001
    • Cytoplasmic Membrane Score: 0.0091
    • Cell wall & surface Score: 0.7871
    • Extracellular Score: 0.2037
  • SignalP: Signal peptide SP(Sec/SPI) length 42 aa
    • SP(Sec/SPI): 0.961076
    • TAT(Tat/SPI): 0.028642
    • LIPO(Sec/SPII): 0.003348
    • Cleavage Site: CS pos: 42-43. VSA-DN. Pr: 0.8820
  • predicted transmembrane helices (TMHMM): 3

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_001810309 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MSRKSIGEKRHSFSMRKLSVGLVSVTVSSFFLMSQGIQSVSADNMESPIHYKYMTEGKLTDEEKSLLVEALPQLAEESDDTYYLVYRSQQFLPNTGFNPTVGTFLFTAGLSLLVLLVSKRENGKKRLVHFLLLTSMGVQLLPASAFGLTSQILSAYNSQLSIGVGEHLPEPLKIEGYQYIGYIKTKKQDNTELSRTVDGKYSAQRDSQPNSTKTSDVVHSADLEWNQGQGKVSLQGEASGDDGLSEKSSIAADNLSSNDSFASQVEQNPDHKGESVVRPTVPEQGNPVSATTVQSAEEEVLATTNDRPEYKLPLETKGTQEPGHEGEAAVREDLPVYTKPLETKGTQGPGHEGEAAVREEEPAYTEPLATKGTQEPGHEGKATVREETLEYTEPVATKGTQEPEHEGEAAVEEELPALEVTTRNRTEIQNIPYTTEEIQDPTLLKNRRKIERQGQAGTRTIQYEDYIVNGNVVETKEVSRTEVAPVNEVVKVGTLVKVKPTVEITNLTKVENKKSITVSYNLIDTTSAYVSAKTQVFHGDKLVKEVDIENPAKEQVISGLDYYTPYTVKTHLTYNLGENNEENTETSTQDFQLEYKKIEIKDIDSVELYGKENDRYRRYLSLSEAPTDTAKYFVKVKSDRFKEMYLPVKSITENTDGTYKVTVAVDQLVEEGTDGYKDDYTFTVAKSKAEQPGVYTSFKQLVTAMQSNLSGVYTLASDMTADEVSLGDKQTSYLTGAFTGSLIGSDGTKSYAIYDLKKPLFDTLNGATVRDLDIKTVSADSKENVAALAKAANSANINNVAVEGKISGAKSVAGLVASATNTVIENSSFTGKLIANHQDSNKNDTGGIVGNITGNSSRVNKVRVDALISTNARNNNQTAGGIVGRLENGALISNSVATGEIRNGQGYSRVGGIVGSTWQNGRVNNVVSNVDVGDGYVITGDQYAAADVKNASTSVDNRKADRFATKLSKDQIDAKVADYGITVTLDDTGQDLKRNLREVDYTRLNKAEAERKVAYSNIEKLMPFYNKDLVVHYGNKVATTDKLYTTELLDVVPMKDDEVVTDINNKKNSINKVMLHFKDNTVEYLDVTFKENFINSQVIEYNVTGKEYIFTPEAFVSDYTAITNNVLSDLQNVTLNSEATKKVLGAANDAALDNLYLDRQFEEVKANIAEHLRKVLAMDKSINTTGDGVVEYVSEKIKNNKEAFMLGLTYMNRWYDINYGKMNTKDLSTYKFDFNGNNETSTLDTIVALGNSGLDNLRASNTVGLYANKLASVKGEDSVFDFVEAYRKLFLPNKTNNEWFKENTKAYIVEMKSDIAEVREKQESPTADRKYSLGVYDRISAPSWGHKSMLLPLLTLPEESVYISSNMSTLAFGSYERYRDSVDGVILSGDALRTYVRNRVDIAAKRHRDHYDIWYNLLDSASKEKLFRSVIVYDGFNVKDETGRTYWARLTDKNIGSIKEFFGPVGKWYEYNSSAGAYANGSLTHFVLDRLLDAYGTSVYTHEMVHNSDSAIYFEGNGRREGLGAELYALGLLQSVDSVNSHILALNTLYKAEKDDLNRLHTYNPVERFDSDEALQSYMHGSYDVMYTLDAMEAKAILAQNNDVKKKWFRKIENYYVRDTRHNKDTHAGNKVRPLTDEEVANLTSLNSLIDNDIINRRSYDDNREYKRNGYYTISMFSPVYAALSNSKGAPGDIMFRKIAYELLAEKGYHKGFLPYVSNQYGAEAFASGSKTFSSWHGRDVALVTDDLVFKKVFNGEYSSWADFKKAMFKQRIDKQDNLKPITIQYELGNPNSTKEVTITTAAQMQQLINEAAAKDITNIDRATSHTPASWVHLLKQKIYNAYLRTTDDFRNSIYK

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

  • PneumoExpress for strain D39V:

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

Damiana Chiavolini, Guido Memmi, Tiziana Maggi, Francesco Iannelli, Gianni Pozzi, Marco R Oggioni
The three extra-cellular zinc metalloproteinases of Streptococcus pneumoniae have a different impact on virulence in mice.
BMC Microbiol: 2003, 3;14
[PubMed:12841855] [WorldCat.org] [DOI] (I e)Marco R Oggioni, Guido Memmi, Tiziana Maggi, Damiana Chiavolini, Francesco Iannelli, Gianni Pozzi
Pneumococcal zinc metalloproteinase ZmpC cleaves human matrix metalloproteinase 9 and is a virulence factor in experimental pneumonia.
Mol Microbiol: 2003, 49(3);795-805
[PubMed:12864860] [WorldCat.org] [DOI] (P p)Balaraj B Menon, Bharathi Govindarajan
Identification of an atypical zinc metalloproteinase, ZmpC, from an epidemic conjunctivitis-causing strain of Streptococcus pneumoniae.
Microb Pathog: 2013, 56;40-6
[PubMed:23168398] [WorldCat.org] [DOI] (I p)

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