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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 14-DEC-2020

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae NU83127
  • locus tag: EL277_RS03370 [old locus tag: SPNU_0629 ]
  • pan locus tag?: PNEUPAN001610000
  • symbol: EL277_RS03370
  • pan gene symbol?: menH
  • synonym:
  • product: alpha/beta hydrolase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: EL277_RS03370 [old locus tag: SPNU_0629 ]
  • symbol: EL277_RS03370
  • product: alpha/beta hydrolase
  • replicon: chromosome
  • strand: +
  • coordinates: 647750..648367
  • length: 618
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NZ_AP018936 (647750..648367) NCBI
  • BioCyc: EL277_RS03370 BioCyc
  • MicrobesOnline:
  • PneumoBrowse for strain D39V:

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    ATGAAATTAATATTTTTGCATGGGTTAGGGCAGTCAGCAGAGTCTTGGAAAGAAGTTCGG
    AATCTACTGACAGATTATCCTTCTGAGGCTATCGAGTTATTTCCTTCTGGAGTTAGTAAC
    TATCAACAAGCTAAAGAGCGAGTTTATCAGCACCTAGCTCAAGAGACAGAACCTTTTGTT
    TTGATTGGATTGTCCTTAGGTGCTGCCCTGACACTAGAACTTTCCAGTTACGATTTACCA
    AATCTTCGAGCTTTGATTCTGTCAGGATGCCCGCTTAAATTAGCAGGGAATATCCTATTT
    TATCTTCAATTGCTGATTTTTAAACTACTTCCCAAAAGAGTATTTGAAAAACAGGGAGCA
    GACAAGACTCTTATGGTCGGAGTTTCTGAGGAGTTGAAGACACTTGATTTAACGGATATA
    GCAGGAACTTACCCTTATCCAACCTTACTAATTTGTGGCAGCAAAGATAAACCGAATCTT
    AGTTCTATGAAAGCTCTCCATAGACTGTTAACAGATTCGCAGTTTCAGATCATTCCTGAT
    GGCCCTCATGTCTTGAATAAGGCAAAACCAAAGGAGTTTGTAGAAAAGACCAGAAGTTTC
    CTTGAATTGCTGAAATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    618

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: EL277_RS03370 [old locus tag: SPNU_0629 ]
  • symbol: EL277_RS03370
  • description: alpha/beta hydrolase
  • length: 205
  • theoretical pI: 8.19864
  • theoretical MW: 22958.7
  • GRAVY: -0.000487804

⊟Function[edit | edit source]

  • TIGRFAM:
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Menaquinone and ubiquinone 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase (TIGR03695; EC 4.2.99.20; HMM-score: 48.8)
    and 5 more
    proline-specific peptidase (TIGR01250; HMM-score: 38.3)
    Metabolism Energy metabolism Other 3-oxoadipate enol-lactonase (TIGR02427; EC 3.1.1.24; HMM-score: 37.3)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Biotin pimelyl-[acyl-carrier protein] methyl ester esterase (TIGR01738; EC 3.1.1.85; HMM-score: 25.5)
    pyrimidine utilization protein D (TIGR03611; HMM-score: 20.9)
    Metabolism Energy metabolism Photosynthesis putative magnesium chelatase accessory protein (TIGR03056; HMM-score: 18.2)
  • TheSEED: data available for Hungary19A-6, TIGR4
  • PFAM:
    AB_hydrolase (CL0028) Abhydrolase_6; Alpha/beta hydrolase family (PF12697; HMM-score: 43.8)
    and 6 more
    Hydrolase_4; Serine aminopeptidase, S33 (PF12146; HMM-score: 23.7)
    Abhydrolase_2; Phospholipase/Carboxylesterase (PF02230; HMM-score: 23.2)
    Abhydrolase_11; Alpha/beta hydrolase domain (PF20408; HMM-score: 17.1)
    Abhydrolase_1; alpha/beta hydrolase fold (PF00561; HMM-score: 15.1)
    FSH1; Serine hydrolase (FSH1) (PF03959; HMM-score: 14.6)
    Thioesterase; Thioesterase domain (PF00975; HMM-score: 12.3)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 1.78
    • Cytoplasmic Membrane Score: 8.16
    • Cellwall Score: 0.06
    • Extracellular Score: 0.01
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.025111
    • TAT(Tat/SPI): 0.00018
    • LIPO(Sec/SPII): 0.003904
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000766580 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MKLIFLHGLGQSAESWKEVRNLLTDYPSEAIELFPSGVSNYQQAKERVYQHLAQETEPFVLIGLSLGAALTLELSSYDLPNLRALILSGCPLKLAGNILFYLQLLIFKLLPKRVFEKQGADKTLMVGVSEELKTLDLTDIAGTYPYPTLLICGSKDKPNLSSMKALHRLLTDSQFQIIPDGPHVLNKAKPKEFVEKTRSFLELLK

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

  • PneumoExpress for strain D39V:

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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