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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 12-FEB-2025

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae NU83127
  • locus tag: EL277_RS03415 [old locus tag: SPNU_0638 ]
  • pan locus tag?: PNEUPAN001591000
  • symbol: EL277_RS03415
  • pan gene symbol?: —
  • synonym:
  • product: SDR family NAD(P)-dependent oxidoreductase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: EL277_RS03415 [old locus tag: SPNU_0638 ]
  • symbol: EL277_RS03415
  • product: SDR family NAD(P)-dependent oxidoreductase
  • replicon: chromosome
  • strand: +
  • coordinates: 655472..656227
  • length: 756
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NZ_AP018936 (655472..656227) NCBI
  • BioCyc: EL277_RS03415 BioCyc
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_0587 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    ATGCCTACTATTCTCATTACCGGAGCTAGCGGTGGTCTAGCTCAAGAAATGGTCAAACTC
    CTGCCCAATGACCAACTCATCTTGCTTGGTAGAAATAAGGAAAAATTAGCCCAACTCTAC
    GGAAATTATTCCCATGCAGAATTGATTGAAATTGATATTACCGACGATTCAGCCCTAGAA
    GCTCTGGTAACTGATCTTTATCTCCGCTATGGCAAGATTGATGTCTTGATTAACAACGCT
    GGTTACGGGATTTTTGAGGGATTTGACCAGATTGCTGATAAAGATATTCACCAGATGTTT
    GAGGTCAATACCTTTGCCCTGATGAATCTGTCTCGTCACCTTGCGGCTCGTATGAAGGAA
    AGCAGCAAAGGGCATATCATCAACATCGTCAGCATGGCAGGTCTAATAGCTACTGGCAAG
    TCTAGTCTTTACTCAGCGACCAAGTTTGCGGCTATTGGTTTTTCAAATGCTCTGCGACTC
    GAACTTATGCCCTATGGAGTCTATGTGACAACAGTCAATCCAGGACCAATCCGTACAGGA
    TTTTTCGACCAAGCCGACCCAGATGGAACTTATCTTAAATCGGTTGATCGCTTCCTGCTA
    GAACCAGATGCAGTGGCTAAAAAGATTGTCAAGATTATAGGAAAAAACAAACGAGAACTC
    AATCTCCCGATTTTGTTGAACCTAGCCCATAAGTTTTATACTCTCTTTCCCAAGCTAGCT
    GATAAGTTGGCAGGGGAAACTTTTAATTATAAGTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    756

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: EL277_RS03415 [old locus tag: SPNU_0638 ]
  • symbol: EL277_RS03415
  • description: SDR family NAD(P)-dependent oxidoreductase
  • length: 251
  • theoretical pI: 7.8331
  • theoretical MW: 27776.1
  • GRAVY: 0.0501992

⊟Function[edit | edit source]

  • reaction:
    EC 1.1.1.-?  ExPASy
  • TIGRFAM:
    2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase (TIGR04316; EC 1.3.1.28; HMM-score: 95)
    3-hydroxybutyrate dehydrogenase (TIGR01963; HMM-score: 93.2)
    Metabolism Energy metabolism Fermentation acetoin reductases (TIGR02415; EC 1.1.1.-; HMM-score: 88.4)
    Metabolism Fatty acid and phospholipid metabolism Biosynthesis 3-oxoacyl-[acyl-carrier-protein] reductase (TIGR01830; EC 1.1.1.100; HMM-score: 86.2)
    acetoacetyl-CoA reductase (TIGR01829; EC 1.1.1.36; HMM-score: 83)
    Unknown function Enzymes of unknown specificity SDR family mycofactocin-dependent oxidoreductase (TIGR03971; EC 1.1.99.-; HMM-score: 77.8)
    and 10 more
    Metabolism Energy metabolism Biosynthesis and degradation of polysaccharides 2-deoxy-D-gluconate 3-dehydrogenase (TIGR01832; EC 1.1.1.125; HMM-score: 72.6)
    2-hydroxycyclohexanecarboxyl-CoA dehydrogenase (TIGR03206; EC 1.1.1.-; HMM-score: 70.4)
    rhamnulose-1-phosphate aldolase/alcohol dehydrogenase (TIGR02632; EC 1.1.1.1,4.1.2.19; HMM-score: 62.9)
    Unknown function Enzymes of unknown specificity SDR family mycofactocin-dependent oxidoreductase (TIGR04504; EC 1.1.99.-; HMM-score: 51.7)
    cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase (TIGR03325; EC 1.3.1.56; HMM-score: 50.3)
    Metabolism Fatty acid and phospholipid metabolism Biosynthesis putative 3-oxoacyl-(acyl-carrier-protein) reductase (TIGR01831; HMM-score: 41.4)
    sepiapterin reductase (TIGR01500; EC 1.1.1.153; HMM-score: 40.3)
    pteridine reductase (TIGR02685; EC 1.5.1.33; HMM-score: 26.5)
    Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides dTDP-4-dehydrorhamnose reductase (TIGR01214; EC 1.1.1.133; HMM-score: 22.1)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Heme, porphyrin, and cobalamin precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit (TIGR02469; EC 2.1.1.132; HMM-score: 12.6)
  • TheSEED: data available for D39, Hungary19A-6, TIGR4
  • PFAM:
    NADP_Rossmann (CL0063) adh_short; short chain dehydrogenase (PF00106; HMM-score: 160.4)
    and 6 more
    adh_short_C2; Enoyl-(Acyl carrier protein) reductase (PF13561; HMM-score: 99.3)
    KR; KR domain (PF08659; HMM-score: 45.3)
    NAD_binding_10; NAD(P)H-binding (PF13460; HMM-score: 22.1)
    Epimerase; NAD dependent epimerase/dehydratase family (PF01370; HMM-score: 19.6)
    RmlD_sub_bind; RmlD substrate binding domain (PF04321; HMM-score: 19.3)
    Sacchrp_dh_NADP; Saccharopine dehydrogenase NADP binding domain (PF03435; HMM-score: 16.2)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.67
    • Cytoplasmic Membrane Score: 0.01
    • Cellwall Score: 0.15
    • Extracellular Score: 0.17
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic Membrane
    • Cytoplasmic Score: 0.3405
    • Cytoplasmic Membrane Score: 0.6483
    • Cell wall & surface Score: 0.0004
    • Extracellular Score: 0.0108
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.008049
    • TAT(Tat/SPI): 0.00021
    • LIPO(Sec/SPII): 0.000983
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_001142146 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MPTILITGASGGLAQEMVKLLPNDQLILLGRNKEKLAQLYGNYSHAELIEIDITDDSALEALVTDLYLRYGKIDVLINNAGYGIFEGFDQIADKDIHQMFEVNTFALMNLSRHLAARMKESSKGHIINIVSMAGLIATGKSSLYSATKFAAIGFSNALRLELMPYGVYVTTVNPGPIRTGFFDQADPDGTYLKSVDRFLLEPDAVAKKIVKIIGKNKRELNLPILLNLAHKFYTLFPKLADKLAGETFNYK

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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