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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 14-DEC-2020

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae NU83127
  • locus tag: EL277_RS04890 [old locus tag: SPNU_0928 ]
  • pan locus tag?: PNEUPAN001998000
  • symbol: EL277_RS04890
  • pan gene symbol?: coaE
  • synonym:
  • product: dephospho-CoA kinase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: EL277_RS04890 [old locus tag: SPNU_0928 ]
  • symbol: EL277_RS04890
  • product: dephospho-CoA kinase
  • replicon: chromosome
  • strand: +
  • coordinates: 924861..925466
  • length: 606
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

  • Location: NZ_AP018936 (924861..925466) NCBI
  • BioCyc: EL277_RS04890 BioCyc
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_0859 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    ATGGGAAAAATCATCGGAATCACTGGGGGAATTGCCTCTGGTAAGTCAACTGTGACAAAT
    TTTCTAAGACAGCAAGGCTTTCAAGTAGTGGATGCCGACGCAGTCGTCCACCAACTACAG
    AAACCTGGTGGTCGTCTGTTTGAGGCTCTAGTACAGCACTTTGGGCAAGAAATCATTCTT
    GAAAACGGAGAACTCAATCGCCCTCTCCTAGCTAGTCTCATCTTTTCAAATCCTGATGAA
    CGAGAATGGTCTAAGCAAATTCAAGGGGAGATTATCCGTGAGGAACTGGCTACTTTGAGA
    GAACAGTTGGCTCAGACAGAAGAGATTTTCTTCATGGATATTCCCCTACTTTTTGAGCAG
    GACTACAGCGATTGGTTTGCTGAGACTTGGTTGGTCTATGTGGACCGAGATGCCCAAGTG
    GAACGCTTAATGAAAAGGGACCAGTTGTCCAAAGATGAAGCTGAGTCTCGTCTGGCAGCC
    CAGTGGCCTTTAGAAAAAAAGAAATATTTGGCCAGCCAGGTTCTTGATAATAATGGCAAT
    CAGAACCAGCTTCTTAATCAAGTGCATATCCTTCTTGAGGGAGGTAGGCAAGATGACAGA
    GATTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    606

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: EL277_RS04890 [old locus tag: SPNU_0928 ]
  • symbol: EL277_RS04890
  • description: dephospho-CoA kinase
  • length: 201
  • theoretical pI: 4.45273
  • theoretical MW: 23052.8
  • GRAVY: -0.468657

⊟Function[edit | edit source]

  • reaction:
    EC 2.7.1.24?  ExPASy
    Dephospho-CoA kinase ATP + 3'-dephospho-CoA = ADP + CoA
  • TIGRFAM:
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Pantothenate and coenzyme A dephospho-CoA kinase (TIGR00152; EC 2.7.1.24; HMM-score: 183.8)
    and 4 more
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Salvage of nucleosides and nucleotides uridine kinase (TIGR00235; EC 2.7.1.48; HMM-score: 14.4)
    Metabolism Central intermediary metabolism Sulfur metabolism adenylyl-sulfate kinase (TIGR00455; EC 2.7.1.25; HMM-score: 12.5)
    putative cytidylate kinase (TIGR02173; EC 2.7.4.14; HMM-score: 11.5)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking type I secretion system ATPase (TIGR01846; HMM-score: 10.3)
  • TheSEED: data available for D39, Hungary19A-6, TIGR4
  • PFAM:
    P-loop_NTPase (CL0023) CoaE; Dephospho-CoA kinase (PF01121; HMM-score: 183.4)
    and 4 more
    AAA_28; AAA domain (PF13521; HMM-score: 28.9)
    dNK; Deoxynucleoside kinase (PF01712; HMM-score: 23.4)
    AAA_18; AAA domain (PF13238; HMM-score: 19.9)
    PRK; Phosphoribulokinase / Uridine kinase family (PF00485; HMM-score: 11.5)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 1.78
    • Cytoplasmic Membrane Score: 8.16
    • Cellwall Score: 0.06
    • Extracellular Score: 0.01
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.006101
    • TAT(Tat/SPI): 0.000266
    • LIPO(Sec/SPII): 0.001814
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_126443113 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MGKIIGITGGIASGKSTVTNFLRQQGFQVVDADAVVHQLQKPGGRLFEALVQHFGQEIILENGELNRPLLASLIFSNPDEREWSKQIQGEIIREELATLREQLAQTEEIFFMDIPLLFEQDYSDWFAETWLVYVDRDAQVERLMKRDQLSKDEAESRLAAQWPLEKKKYLASQVLDNNGNQNQLLNQVHILLEGGRQDDRD

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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