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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 12-FEB-2025

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae NU83127
  • locus tag: EL277_RS06800 [old locus tag: SPNU_1295 ]
  • pan locus tag?: PNEUPAN002651000
  • symbol: aroB
  • pan gene symbol?: aroB
  • synonym:
  • product: 3-dehydroquinate synthase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: EL277_RS06800 [old locus tag: SPNU_1295 ]
  • symbol: aroB
  • product: 3-dehydroquinate synthase
  • replicon: chromosome
  • strand: -
  • coordinates: 1294427..1295494
  • length: 1068
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NZ_AP018936 (1294427..1295494) NCBI
  • BioCyc: EL277_RS06800 BioCyc
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_1209 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    ATGAAAATCAGAATCGATATTCCTCATCATCCTTATGATATTCAGATTGAAAAAGGTTGT
    ATGGCCCAGGCTGGTCAGTGGTTGCGAGAACTCTGGCAACCGCAAAAGGTAGTCATTGTG
    ACAGATAACCATGTAGCCTCTCTCTATGCAGAGAAGGTCAAGCTCAGCCTAGAAGATGCT
    GGTTTTCAGGTAGCTGTTTTTGATTTCTTAGAAGGTGAAGAAAGAAAGAATTTAACTACT
    GTTCAGAAAGTCTATGAATTTCTAGTCAAGCAAGGTCTGACTCGTAGCGATGGAATCGTT
    GCTCTTGGTGGTGGCGTTGTTGGGGACCTGGCTGGATTTGTAGCCTCTACCTATATGCGG
    GGTATTCACTTTGTTCAGATTCCGACTAGTTTGACAGCTCAGGTTGATTCTTCTATCGGT
    GGAAAGACAGGCGTTAACACACCATTTGCTAAAAATATGGTGGGGACCTTTGCCCAACCA
    GATGGGGTTCTGATTGATCCACTTGTTCTTGAAACCCTCGGAAAAAGAGAGTTGATTGAA
    GGGATGGGTGAAGTTATCAAGTATGGCTTGATTGAGGATCCAGAACTGTGGGCTCTCTTG
    ACGGGGCTGAATGGTTCTGTTGAGAGCATTTTGGAACATGCAGAGACCTTGATTGAACAT
    TCTTGTCAGGTGAAGCGCAAGATGGTGGTTGAAGATGAGTTGGACAATGGTATTCGTCTT
    TACCTCAATTTTGGCCACACTATTGGCCATGCCATCGAAGCGACTGCCGGTTATGGCAAG
    GTCATGCATGGAGAGGCTGTTGCCATGGGAATGGTACAGATTTCCAAGATTGCTGAGGAA
    AAAGGCCTCATGCCAGCTGGCATTACCCAATCTATCACAGAGATGTGTCAGAAATTCGGC
    TTGCCTGTTGACTATGAAAATTGGGAAGTTGACAAGCTTTATCAGGCTCTTACTCATGAC
    AAGAAAGCGCGTGGTAACACCTTGAAATTGGTCTTGGTGCCAGAGCTTGGTTCAGCGACC
    ATTCATCCAGTTTCTCTGGAAGAGATGAAAGACTACTTGGTAAAATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1068

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: EL277_RS06800 [old locus tag: SPNU_1295 ]
  • symbol: AroB
  • description: 3-dehydroquinate synthase
  • length: 355
  • theoretical pI: 5.13981
  • theoretical MW: 39029.8
  • GRAVY: -0.00957746

⊟Function[edit | edit source]

  • reaction:
    EC 4.2.3.4?  ExPASy
    3-dehydroquinate synthase 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate
  • TIGRFAM:
    Metabolism Amino acid biosynthesis Aromatic amino acid family 3-dehydroquinate synthase (TIGR01357; EC 4.2.3.4; HMM-score: 414.4)
    and 2 more
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Lipoate putative sugar phosphate phospholyase (cyclizing) (TIGR04425; EC 4.2.3.-; HMM-score: 262.1)
    Metabolism Energy metabolism Sugars lactaldehyde reductase (TIGR02638; EC 1.1.1.77; HMM-score: 11.7)
  • TheSEED: data available for D39, Hungary19A-6, TIGR4
  • PFAM:
    DHQS (CL0224) DHQ_synthase; 3-dehydroquinate synthase (PF01761; HMM-score: 337.8)
    and 2 more
    Fe-ADH_2; Iron-containing alcohol dehydrogenase (PF13685; HMM-score: 63.1)
    Fe-ADH; Iron-containing alcohol dehydrogenase (PF00465; HMM-score: 59.8)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9994
    • Cytoplasmic Membrane Score: 0.0002
    • Cell wall & surface Score: 0.0001
    • Extracellular Score: 0.0004
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.003066
    • TAT(Tat/SPI): 0.000147
    • LIPO(Sec/SPII): 0.000591
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000702164 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MKIRIDIPHHPYDIQIEKGCMAQAGQWLRELWQPQKVVIVTDNHVASLYAEKVKLSLEDAGFQVAVFDFLEGEERKNLTTVQKVYEFLVKQGLTRSDGIVALGGGVVGDLAGFVASTYMRGIHFVQIPTSLTAQVDSSIGGKTGVNTPFAKNMVGTFAQPDGVLIDPLVLETLGKRELIEGMGEVIKYGLIEDPELWALLTGLNGSVESILEHAETLIEHSCQVKRKMVVEDELDNGIRLYLNFGHTIGHAIEATAGYGKVMHGEAVAMGMVQISKIAEEKGLMPAGITQSITEMCQKFGLPVDYENWEVDKLYQALTHDKKARGNTLKLVLVPELGSATIHPVSLEEMKDYLVK

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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