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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 09-MAY-2015

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae NCTC7465
  • locus tag: ERS445053_00333 [new locus tag: AT689_RS01655 ]
  • pan locus tag?: PNEUPAN000826000
  • symbol: ugd_2
  • pan gene symbol?: ugd
  • synonym:
  • product: UDP-glucose 6-dehydrogenase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: ERS445053_00333 [new locus tag: AT689_RS01655 ]
  • symbol: ugd_2
  • product: UDP-glucose 6-dehydrogenase
  • replicon: chromosome
  • strand: -
  • coordinates: 321557..322729
  • length: 1173
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    ATGAATATAGCAGTAATTGGTTTGGGGCATGTTGGGCTGGCCTACGCGTTACTATTTGCA
    TCTAAATATAAAGTTGTTGCATATGATATAGATTCTGTAAAAATAAATAATTTAAAAAAG
    GGCACTCTTCCATCTAAAAATGAAGAGCTTATGAAGTTTTTTTGCGAGAATAACTTAAAT
    ATTACTTTTTTTGATACATTTTCTGAAATTAAAAATAATATTGATTATTATATTATTGCG
    CTTCCGACAGATTATGATGAGAAAATTGGTAGTTTTAATACATATGAAATCGAACAAACG
    GTATCGAAGATTCTGAGGGTAAAACCTAATGGAAAGATTATTTTAAAGTCAACAGTTCCG
    ATCGGCTTTTCAAACAAATTAAAAAGGCTGTTTGATACAAAAAATATCATTTTTGTCCCT
    GAATTTTTGAGAGAAGGTTGTTCTATATATGATAATTTATATCCAAGTCGCATAGTTGTT
    GGAGATGAGACAGTTGAAGGAAGAAAAATTGCAGAGTTGTTCCTTTCGATTAGTACTCAT
    AGTACTGCCAATATTAAAAATGTTATGTTAGTTTCTCCTACTGAAGCAGAAGCAATTAAG
    CTTTTTTCTAACACATTCTTAGCTCTCCGTGTTGCTTTTTTTAATGAACTAGATTCTTTT
    GCTGAGAGGAGAAGTTTAAATGCTGAAGTTGTAATAAAAGGTGTTTGTTTAGATCCAAGA
    ATTGGAAATTTTTATAATAATCCTTCTTTTGGATTTGGAGGATATTGTCTTCCCAAAGAT
    ACTAAACAATTAAAAAAAGAATTTATAGAAATAAATGCCCCAGTGATAGAAGCGATTGAT
    ATTTCAAACACAAATAGAAAACAGTTCATAGTTAAACAAATATTGGAACGAAAGCCAAAG
    ATAGTAGGAATATATAAATTGGGGATGAAATATAATTCAGATAATTACAAAGAGTCAGCT
    ATTTTAAGTATAATTAATGAACTATTGATTGTCGGTATAAAAATTTTAGTATATGAACCA
    AATTTAAACGTTAGTATAGATAACGTAATTTTTGAAAAGAATTTTGAACTATTTATAAAA
    CAAAGTGATCTAATTGTTGCAAATAGATGGGATAGGGACCTTGAAGCTTATAAAGATAAA
    GTTTACACAAGGGGGATCTGGATAAGAGATTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1173

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: ERS445053_00333 [new locus tag: AT689_RS01655 ]
  • symbol: Ugd_2
  • description: UDP-glucose 6-dehydrogenase
  • length: 390
  • theoretical pI: 8.71359
  • theoretical MW: 44566.4
  • GRAVY: -0.0397436

⊟Function[edit | edit source]

  • reaction:
    EC 1.1.1.22?  ExPASy
    UDP-glucose 6-dehydrogenase UDP-glucose + 2 NAD+ + H2O = UDP-glucuronate + 2 NADH
  • TIGRFAM:
    nucleotide sugar dehydrogenase (TIGR03026; HMM-score: 283.9)
    and 1 more
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Pantothenate and coenzyme A 2-dehydropantoate 2-reductase (TIGR00745; EC 1.1.1.-; HMM-score: 11.9)
  • TheSEED: data available for D39, Hungary19A-6
  • PFAM:
    NADP_Rossmann (CL0063) UDPG_MGDP_dh_N; UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain (PF03721; HMM-score: 91.3)
    6PGD_C (CL0106) UDPG_MGDP_dh; UDP-glucose/GDP-mannose dehydrogenase family, central domain (PF00984; HMM-score: 85.6)
    and 8 more
    HUP (CL0039) UDPG_MGDP_dh_C; UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain (PF03720; HMM-score: 27)
    NADP_Rossmann (CL0063) 3HCDH_N; 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain (PF02737; HMM-score: 16.3)
    ApbA; Ketopantoate reductase PanE/ApbA (PF02558; HMM-score: 15.6)
    P-loop_NTPase (CL0023) KdpD; Osmosensitive K+ channel His kinase sensor domain (PF02702; HMM-score: 15.1)
    NADP_Rossmann (CL0063) GFO_IDH_MocA; Oxidoreductase family, NAD-binding Rossmann fold (PF01408; HMM-score: 14.7)
    NAD_binding_2; NAD binding domain of 6-phosphogluconate dehydrogenase (PF03446; HMM-score: 13.2)
    NAD_Gly3P_dh_N; NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus (PF01210; HMM-score: 12.9)
    2-Hacid_dh_C; D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain (PF02826; HMM-score: 11.6)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.67
    • Cytoplasmic Membrane Score: 0.01
    • Cellwall Score: 0.15
    • Extracellular Score: 0.17
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.8891
    • Cytoplasmic Membrane Score: 0.0261
    • Cell wall & surface Score: 0.0007
    • Extracellular Score: 0.0841
  • SignalP: Signal peptide SP(Sec/SPI) length 27 aa
    • SP(Sec/SPI): 0.558537
    • TAT(Tat/SPI): 0.004976
    • LIPO(Sec/SPII): 0.045062
    • Cleavage Site: CS pos: 27-28. VVA-YD. Pr: 0.5153
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: COT03596 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MNIAVIGLGHVGLAYALLFASKYKVVAYDIDSVKINNLKKGTLPSKNEELMKFFCENNLNITFFDTFSEIKNNIDYYIIALPTDYDEKIGSFNTYEIEQTVSKILRVKPNGKIILKSTVPIGFSNKLKRLFDTKNIIFVPEFLREGCSIYDNLYPSRIVVGDETVEGRKIAELFLSISTHSTANIKNVMLVSPTEAEAIKLFSNTFLALRVAFFNELDSFAERRSLNAEVVIKGVCLDPRIGNFYNNPSFGFGGYCLPKDTKQLKKEFIEINAPVIEAIDISNTNRKQFIVKQILERKPKIVGIYKLGMKYNSDNYKESAILSIINELLIVGIKILVYEPNLNVSIDNVIFEKNFELFIKQSDLIVANRWDRDLEAYKDKVYTRGIWIRD

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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