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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 12-MAY-2020

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae 6A-10
  • locus tag: HKM25_1040 [new locus tag: HKM25_RS05085 ]
  • pan locus tag?: PNEUPAN002137000
  • symbol: HKM25_1040
  • pan gene symbol?: mefE
  • synonym:
  • product: transmembrane secretion effector family protein

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: HKM25_1040 [new locus tag: HKM25_RS05085 ]
  • symbol: HKM25_1040
  • product: transmembrane secretion effector family protein
  • replicon: chromosome
  • strand: +
  • coordinates: 999424..1000566
  • length: 1143
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: CP053210 (999424..1000566) NCBI
  • BioCyc:
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_0950 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    ATGTTTGACTTTGCGAATAATACCTTTCTTGCAGGATTAAATCCAACATCTTTATCATTG
    GTTGCAGTATATCAGTCACTAGAAAGTGTGATAGGTGTTCTTTTTAATTTATTTGGTGGA
    GTCATTGCAGATAGTTTCAAGCGGAAAAAAATTATTATTGTTGCAAATATCTTATGTGGT
    ATTGCTTGTATAATTCTTTCATTCATATCACAAGAGCAGTGGATGGTCTTTGCAATTGTC
    ATCACTAATATTATCTTGGCATTTATGAGTGCTTTTTCTGGACCGTCCTATAAAGCATTT
    ACAAAAGAAATTGTAAAAAAGGATAGTATATCACAACTTAATTCATTGCTAGAGATAACA
    AGTACTATAATTAAAGTAACAATACCAATGGTAGCAATTTTATTATATAAGCTACTTGGG
    ATACATGGTGTTTTACTATTGGATGGATTCTCATTTCTAATTGCTGCATCACTGATTTCC
    TTTATTGTACCCGTTAATGACGAAGTGGTCACAAAGGATAAAATGACAATAGGAGGAGTT
    TTAAATGACTTAAAAATAGGGTTTAAGTATATTTATAGTCATAAGACAATATTTATGATT
    ATTATTCTCTCTGCTTTTGTTAATTTTTTTCTAGCAGCTTATAATTTATTGTTACCTTAT
    AGTAATCAAATGTTTGGAGAAATTTCAGATGGGCTTTATGGTGTTTTTCTAACTGCGGAA
    GCAATTGGAGGATTTATTGGAGCGATATTAAGTGGTGTTATAAATAAAACCTTGTCAAGC
    AAACGTTTAATGGTCTTCTTATCATGTTCAGGATTGATGTTAATGCTATCAACGCCACTC
    TATTTTTTGTTTCAAAACTTCATTATTCTAGCCTTTTCTCCGGCATTATTTAGTCTATTT
    ATTTCTATTTTTAATATTCAATTTTTCTCTATTGTTCAAAGAGAAGTTGATACTGAGTTT
    CTCGGTAGAGTCTTTGGAATCATCTTTACGGTAGCTATTCTTTTTATGCCAGTTGGGTCT
    GGATTTTTCTCAGTAGTTTTAAATCCTAACAATACTTTTAATCTTTTTATTATTGGTGTA
    TCTATTACGATATTATCGCTAATATTCAGCACGCTATTGAAGAGGTATGATAAAAATAGC
    TGA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1143

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: HKM25_1040 [new locus tag: HKM25_RS05085 ]
  • symbol: HKM25_1040
  • description: transmembrane secretion effector family protein
  • length: 380
  • theoretical pI: 8.99839
  • theoretical MW: 41927.8
  • GRAVY: 1.01

⊟Function[edit | edit source]

  • TIGRFAM:
    Metabolism Transport and binding proteins Cations and iron carrying compounds H+ Antiporter protein (TIGR00900; HMM-score: 152.4)
    and 1 more
    multidrug resistance protein (TIGR00880; HMM-score: 18)
  • TheSEED: data available for D39
  • PFAM:
    MFS (CL0015) MFS_1; Major Facilitator Superfamily (PF07690; HMM-score: 77.5)
    MFS_3; Transmembrane secretion effector (PF05977; HMM-score: 65)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 10
    • Cellwall Score: 0
    • Extracellular Score: 0
    • Internal Helices: 11
  • DeepLocPro: Cytoplasmic Membrane
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 0.9994
    • Cell wall & surface Score: 0
    • Extracellular Score: 0.0006
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.003763
    • TAT(Tat/SPI): 0.000152
    • LIPO(Sec/SPII): 0.006643
  • predicted transmembrane helices (TMHMM): 11

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: QJS36748 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MFDFANNTFLAGLNPTSLSLVAVYQSLESVIGVLFNLFGGVIADSFKRKKIIIVANILCGIACIILSFISQEQWMVFAIVITNIILAFMSAFSGPSYKAFTKEIVKKDSISQLNSLLEITSTIIKVTIPMVAILLYKLLGIHGVLLLDGFSFLIAASLISFIVPVNDEVVTKDKMTIGGVLNDLKIGFKYIYSHKTIFMIIILSAFVNFFLAAYNLLLPYSNQMFGEISDGLYGVFLTAEAIGGFIGAILSGVINKTLSSKRLMVFLSCSGLMLMLSTPLYFLFQNFIILAFSPALFSLFISIFNIQFFSIVQREVDTEFLGRVFGIIFTVAILFMPVGSGFFSVVLNPNNTFNLFIIGVSITILSLIFSTLLKRYDKNS

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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