PangenomeTIGR4

serotype 4

D39

serotype 2

D39V

serotype 2

Hungary19A-6

serotype 19A

EF3030

serotype 19F

670-6B

serotype 6B

6A-10

serotype 6A

70585

serotype 5

A026

serotype 19F

A66

serotype 3

AP200

serotype 11A

ASP0581

serotype 12F

ATCC 49619

serotype 19F

ATCC 700669

serotype 23F

BM6001

serotype 19F

BVJ1JL

serotype 1

CGSP14

serotype 14

G54

serotype 19F

HU-OH

serotype 3

Hu15

serotype 19A

Hu17

serotype 19A

INV104

serotype 1

INV200

serotype 14

JJA

serotype 14

MDRSPN001

serotype 19F

NCTC7465

serotype 1

NCTC7466

serotype 2

NU83127

serotype 4

OXC141

serotype 3

P1031

serotype 1

R6

serotype 2

SP49

serotype 19A

SPN032672

serotype 1

SPN034156

serotype 3

SPN034183

serotype 3

SPN994038

serotype 3

SPN994039

serotype 3

SPNA45

serotype 3

ST556

serotype 19F

TCH8431/19A

serotype 19A

Taiwan19F-14

serotype 19F

Xen35

serotype 4

gamPNI0373

serotype 1

NCBI: 12-MAY-2020

⊟Summary

• organism: Streptococcus pneumoniae 6A-10
• locus tag: HKM25_1850 [new locus tag: HKM25_RS09050 ]
• pan locus tag^?: PNEUPAN003328000
• symbol: HKM25_1850
• pan gene symbol^?: —
• synonym:
• product: helix-turn-helix domain protein

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: HKM25_1850 [new locus tag: HKM25_RS09050 ]
• symbol: HKM25_1850
• product: helix-turn-helix domain protein
• replicon: chromosome
• strand: -
• coordinates: 1785238..1786389
• length: 1152
• essential: unknown

⊟Accession numbers

• Location: CP053210 (1785238..1786389) NCBI
• BioCyc:
• MicrobesOnline:
• PneumoBrowse for strain D39V: SPV_1594 PneumoBrowse

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

• 1
  61
  121
  181
  241
  301
  361
  421
  481
  541
  601
  661
  721
  781
  841
  901
  961
  1021
  1081
  1141
  
  ATGTTTAATGGTCGGGTATTGAAAGAATTACGGCTGTTAAATGGTTTAAGTAGAGCAGAA
  TTAGCTCAGAGAATTAATTTAACGGAACAAGCCATTTGGCAGTTTGAGTCCAACGAAACG
  AAACCTAAATTATCAACCAAAATGCATTTGGCCAACCAATTTCATGTTGATTTAACTTAT
  TTTGAACAGGAAGAAGAGAGCATTCGATTTGATTCTTCTGTAATTGCCTTTAGAAATGCA
  GACCTAGCAACACGGAAAACAATAGATATTCAAACTATGTATTTACATAAGGTAGATAGT
  TTGATTGATTATTTTGAAAGTTTTGTAATTATACCTAATATTACAATTCATGACCTAAGT
  AATGTAGTGAGTGAATCTTATCATAAGGGAGAATCCATTGAGGAATTGGCTCTTTATGCC
  AGGGAAAAATTAGGTATTTCAAAAGATAATCATGATTTGCTTTATAAATTAGAACGTTCA
  GGCATCTATATCGTGGAACGATTAATTAATGGCCAAGCTGATGCTTATAGCGCATGGTCA
  AAATTGGGAAGACCTTATATTGTGTTGGGAACGAATAAATCATCTGTACGTCGAAATTTT
  GACTTAGCTCATGAGCTAGGACATATTCTTTTACACAAATATAAAGATATGAATGAAGAT
  GGCAATCGTTTGGAGCAAGAAGCAAATTATTTTGCATCATGTTTTTTATTGCCAAAAGAA
  GAGTTTTTAGTCAAATTTGAAGAGAGGGTTGGCAAGCGTGTCAGCAATCCTGATAGTTAT
  ATTTTATTGAAGTCGGATTTGAATGTTTCGATACAGGCTTTAGAGTATCGAGCTTTTAAG
  TTAGGATTATTGACTCCAAAGCAACATTCTTACTTTTATCGTCAAATTGCGCAAAAAGGT
  TACAAAATGATTGAACCTTTGGATGATCAAATTTTTGTTAAAAAACCAAGCAAAGTAAAG
  AGTATTCTGGACGTCGTTTTGAGTAATCATCTAGTCAGTCTAGCGACTATAATGTCTAAA
  CAAAGTATTCGTTTACAGTTTATAAGCGAAATATTTTCAGTCGAAATGAAATTTTTTGAT
  CAGTATCAAGAAGATAGAAGAACAGATCGATTTGATAACATCATCCCTTTGTACAAAAGA
  AATAATTTATAA
  60
  120
  180
  240
  300
  360
  420
  480
  540
  600
  660
  720
  780
  840
  900
  960
  1020
  1080
  1140
  1152
  

⊟Protein

⊟General

• locus tag: HKM25_1850 [new locus tag: HKM25_RS09050 ]
• symbol: HKM25_1850
• description: helix-turn-helix domain protein
• length: 383
• theoretical pI: 7.85527
• theoretical MW: 44785.9
• GRAVY: -0.373368

⊟Function

• TIGRFAM:
  Hypothetical proteins Conserved TIGR00270 family protein (TIGR00270; HMM-score: 20.5)
  and 2 more
  putative zinc finger/helix-turn-helix protein, YgiT family (TIGR03830; HMM-score: 12.8)
  Unknown function General mobile mystery protein A (TIGR02612; HMM-score: 11.9)
• TheSEED: data available for D39, TIGR4
• PFAM:
  Peptidase_MA (CL0126) Peptidase_M78; IrrE N-terminal-like domain (PF06114; HMM-score: 80.8)
  and 7 more
  HTH (CL0123) HTH_3; Helix-turn-helix (PF01381; HMM-score: 34.1)
  HTH_19; Helix-turn-helix domain (PF12844; HMM-score: 25.4)
  HTH_31; Helix-turn-helix domain (PF13560; HMM-score: 20.6)
  HTH_11; HTH domain (PF08279; HMM-score: 14.8)
  HTH_24; Winged helix-turn-helix DNA-binding (PF13412; HMM-score: 13.8)
  CENP-B_N; CENP-B N-terminal DNA-binding domain (PF04218; HMM-score: 12.6)
  HTH_25; Helix-turn-helix domain (PF13413; HMM-score: 12.5)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• PSORTb: Cytoplasmic
  • Cytoplasmic Score: 7.5
  • Cytoplasmic Membrane Score: 1.15
  • Cellwall Score: 0.62
  • Extracellular Score: 0.73
  • Internal Helices: 0
• DeepLocPro: Cytoplasmic
  • Cytoplasmic Score: 0.7155
  • Cytoplasmic Membrane Score: 0.2473
  • Cell wall & surface Score: 0.0008
  • Extracellular Score: 0.0365
• SignalP: no predicted signal peptide
  • SP(Sec/SPI): 0.002657
  • TAT(Tat/SPI): 0.000295
  • LIPO(Sec/SPII): 0.000666
• predicted transmembrane helices (TMHMM): 0

⊟Accession numbers

• GI:
• RefSeq: QJS37554 NCBI
• UniProt:

⊟Protein sequence

• MFNGRVLKELRLLNGLSRAELAQRINLTEQAIWQFESNETKPKLSTKMHLANQFHVDLTYFEQEEESIRFDSSVIAFRNADLATRKTIDIQTMYLHKVDSLIDYFESFVIIPNITIHDLSNVVSESYHKGESIEELALYAREKLGISKDNHDLLYKLERSGIYIVERLINGQADAYSAWSKLGRPYIVLGTNKSSVRRNFDLAHELGHILLHKYKDMNEDGNRLEQEANYFASCFLLPKEEFLVKFEERVGKRVSNPDSYILLKSDLNVSIQALEYRAFKLGLLTPKQHSYFYRQIAQKGYKMIEPLDDQIFVKKPSKVKSILDVVLSNHLVSLATIMSKQSIRLQFISEIFSVEMKFFDQYQEDRRTDRFDNIIPLYKRNNL

⊟Experimental data

• protein localization:
• interaction partners:

⊟Expression & Regulation

⊟Operon

⊟Regulation

• regulator:

⊟Transcription

• transcription start site:

⊟Expression data

• PneumoExpress for strain D39V: SPV_1594 PneumoExpress

⊟Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊟Other Information

You can add further information about the gene and protein here. [edit]

⊟Literature

⊟References

⊟Relevant publications