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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 12-MAY-2020

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae 6A-10
  • locus tag: HKM25_2228 [new locus tag: HKM25_RS10850 ]
  • pan locus tag?: PNEUPAN003674000
  • symbol: HKM25_2228
  • pan gene symbol?: ulaR2
  • synonym:
  • product: phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 family protein

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: HKM25_2228 [new locus tag: HKM25_RS10850 ]
  • symbol: HKM25_2228
  • product: phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 family protein
  • replicon: chromosome
  • strand: -
  • coordinates: 2103494..2105443
  • length: 1950
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: CP053210 (2103494..2105443) NCBI
  • BioCyc:
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_1961 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    1741
    1801
    1861
    1921
    GTGAGCTTACCTATAAAGGAAGTCAAAGAAGGAATAGATTATTTAGTGCCTTATCTAGCT
    AATAAAGGGATAGTGCTGGATAAAAAACAAGGTCGCTATAGTTTATCAAATCGTACGAAG
    CAGTCTTTGACAGATATTATTAAGTCGGATGAATTGGTTTTACCAAAGTCGACTCGCTTA
    GCTTTAATCTATCTTTACACTTTTTGCCGATTAGATTTTATATCGAATAATCATTACCAA
    GACTTTTTGAAAGTAAGTAAGAATACAACCTTATCTGATATTCAATCATTAAGAAAGATT
    ATGTTAGATAATGATTTGGAGCTAGGGTACAGTAGAGCAAAAGGTTATACTTTACACGGT
    TCAGAGTGGAATAAGCACCGCTTAGCTTTTCAAATGGTTAGTGAGTTGCTGGAATCCTCC
    ATAGGGATTTGGGGTTTGGATTATGTTTTATCCAGTTGGGGGTATTCATTAACTTATGAT
    TTGATAAATCAGGTAGTTAAAGATTATTATGAGAAGCTACAACTAGTACCTATTGTTAAT
    CAATTAAAAGTTTGCCTTTTCGGTTTAGTATTCATTCTGTGTAGGTATCAAAGGGATGTT
    GAAAGAGTATGTCTTTCAGAGACATTAGTATCTCCTGTTATTCAAGATATAACCACTATT
    TTATTGGATACAGTGGTTGATTTGGGAATTATAGATACGGTGTTTTCTGAGGATGATTAT
    CGCTATATCACAGTTTTATTATCAAGTTGCTTTGAAGGTGAAGTAGATGTTGCTCCGGTT
    TACTTTAATCAATTAACAGAGGCTATTATAAGTAGAATGGAAGATATTTCTTTGTTACAT
    TTTAAACAAAGGGAAGGATTGAGAGAAAATCTTCGCCGCCACCTTATACCGGCTTACTAT
    AGATTAAAGTTCGGCCTACCTAGTTCAAATGAATATGTATTGCATGTTAAAGAACATTAT
    CCTGATTTATTTGAATTAGTCAAAGATTCTTTGATGCCCTTGATGGACGCTATTGACAAT
    CCCATACCTGATAGTGAAACAGCATATTTTGTTATCCATTTCGGAGGTTATTTAAAGAAA
    GCAGATACTTTGCCTCAAAAATGGTATAAAGCAGCAATCATTTGTCCTAATGGTGTTAGT
    TCTTCATTGATGTTAAAAGAGAATCTATTAGCATTATTTCCTCAAATTGAGTTTATAGGA
    ACCTCAAAGATTGATGATTTACAGGTGAAAGCTAGTAGTGACTATGATATGGTTTTTTCT
    ACCATAAAGGTGGAGACAGAAAAGCCAAATTATCTAGTTTCGGTTATGATGACTGAAGAG
    CAAGCAATACAACTAGTAGAATTAGTGTTAAAAGATTTTCCGAATTTAGAGTATGGGGAT
    TTTGAGATTGAACAAATCCTGAATATTGTCAAAAGATATGGAATTATTACACAAGAATTG
    GAATTAAGATTGGCGTTAAAGAATTATCTTTACCAAAAAAATGATAGAAAGGAAATTGTA
    CCAGTGCTAGAACAACTCATTACCAAAGAAACCTATCAGGTTAGTTCGCAAAAATTAGGA
    TGGAAGGAGGCGATTCGTTTAGCAGCTAAACCGCTTTTGGATCAAGATAAGATAACTGAG
    AACTACCCTGAGGCAATGATTCAAAAAGTAGAAGAGTTTGGGCCTTTTATTAATTTAGGG
    AAGGGAGTAGCAATTCCTCACGCTCGGCCAGATGAAGGTGTGAATGAAATAGGAATGTCA
    ATGTTAGTTTTGGAAGAACCGATTTATTTATTGGATAATCCAGAACAAGAGGTAAGATTG
    TTGATTTGTATTGCAGCCATTGATAATGAGAGTCATTTAAAGGCTTTGTCACATTTAACA
    ACAATTTTAAGAGATAAAAATCATGTTCAAACTTTAATATCATCAAAAAACTATAATGAT
    ATTAAAATGATAATTAAACAGGAGGATTAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1680
    1740
    1800
    1860
    1920
    1950

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: HKM25_2228 [new locus tag: HKM25_RS10850 ]
  • symbol: HKM25_2228
  • description: phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 family protein
  • length: 649
  • theoretical pI: 4.96054
  • theoretical MW: 74697.9
  • GRAVY: -0.0969183

⊟Function[edit | edit source]

  • TIGRFAM:
    Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids PTS system, fructose subfamily, IIA component (TIGR00848; EC 2.7.1.69; HMM-score: 34.5)
    Signal transduction Signal transduction PTS PTS system, fructose subfamily, IIA component (TIGR00848; EC 2.7.1.69; HMM-score: 34.5)
    Signal transduction Signal transduction PTS PTS IIA-like nitrogen-regulatory protein PtsN (TIGR01419; HMM-score: 34.4)
  • TheSEED: data available for D39, Hungary19A-6, TIGR4
  • PFAM:
    PTase-anion_tr (CL0340) PTS_EIIA_2; Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 (PF00359; HMM-score: 110.1)
    and 2 more
    PRD (CL0166) PRD; PRD domain (PF00874; HMM-score: 64.6)
    Phosphatase (CL0031) PTS_IIB; PTS system, Lactose/Cellobiose specific IIB subunit (PF02302; HMM-score: 24.3)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:
  • genes regulated by 

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.011991
    • TAT(Tat/SPI): 0.000166
    • LIPO(Sec/SPII): 0.001311
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: QJS37876 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MSLPIKEVKEGIDYLVPYLANKGIVLDKKQGRYSLSNRTKQSLTDIIKSDELVLPKSTRLALIYLYTFCRLDFISNNHYQDFLKVSKNTTLSDIQSLRKIMLDNDLELGYSRAKGYTLHGSEWNKHRLAFQMVSELLESSIGIWGLDYVLSSWGYSLTYDLINQVVKDYYEKLQLVPIVNQLKVCLFGLVFILCRYQRDVERVCLSETLVSPVIQDITTILLDTVVDLGIIDTVFSEDDYRYITVLLSSCFEGEVDVAPVYFNQLTEAIISRMEDISLLHFKQREGLRENLRRHLIPAYYRLKFGLPSSNEYVLHVKEHYPDLFELVKDSLMPLMDAIDNPIPDSETAYFVIHFGGYLKKADTLPQKWYKAAIICPNGVSSSLMLKENLLALFPQIEFIGTSKIDDLQVKASSDYDMVFSTIKVETEKPNYLVSVMMTEEQAIQLVELVLKDFPNLEYGDFEIEQILNIVKRYGIITQELELRLALKNYLYQKNDRKEIVPVLEQLITKETYQVSSQKLGWKEAIRLAAKPLLDQDKITENYPEAMIQKVEEFGPFINLGKGVAIPHARPDEGVNEIGMSMLVLEEPIYLLDNPEQEVRLLICIAAIDNESHLKALSHLTTILRDKNHVQTLISSKNYNDIKMIIKQED

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

Muhammad Afzal, Sulman Shafeeq, Oscar P Kuipers
Ascorbic acid-dependent gene expression in Streptococcus pneumoniae and the activator function of the transcriptional regulator UlaR2.
Front Microbiol: 2015, 6;72
[PubMed:25717320] [WorldCat.org] [DOI] (P e)

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