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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 24-APR-2025

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae 6A-10
  • locus tag: HKM25_RS00210 [old locus tag: HKM25_44 ]
  • pan locus tag?: PNEUPAN000508000
  • symbol: tadA
  • pan gene symbol?: tadA
  • synonym:
  • product: tRNA adenosine(34) deaminase TadA

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: HKM25_RS00210 [old locus tag: HKM25_44 ]
  • symbol: tadA
  • product: tRNA adenosine(34) deaminase TadA
  • replicon: chromosome
  • strand: +
  • coordinates: 36585..37052
  • length: 468
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NZ_CP053210 (36585..37052) NCBI
  • BioCyc:
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_0025 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    ATGTATTATACGCTTGAAGAAAAAGAAGTCTTTATGAGGGAGGCTTTGAGAGAGGCTGAG
    ATTGCTCTTGAACACGATGAAATTCCAATTGGTTGTGTGATTGTCAAAGATGGGGAAATC
    ATTGGTCGTGGGCATAATGCGCGTGAGGAATTACAGCGAGCGGTTATGCATGCGGAAATT
    ATGGCTATAGAGGATGCGAACTTGAGTGAGGAGAGCTGGCGCTTGCTGGATTGCACACTT
    TTTGTGACCATTGAACCTTGTGTCATGTGTAGTGGGGCGATTGGGCTTGCCCGCATTCCA
    AATGTGGTCTATGGGGCTAAAAACCAGAAATTTGGCGCTGCTGGAAGTTTGTACGATATC
    TTGACAGATGAGCGTCTTAACCATCGTGTAGAGGTTGAAACGGGAATTTTGGAAGATGAA
    TGTGCAGCTATCATGCAGGACTTTTTTAGAAATAGACGGAAAAAATAA
    60
    120
    180
    240
    300
    360
    420
    468

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: HKM25_RS00210 [old locus tag: HKM25_44 ]
  • symbol: TadA
  • description: tRNA adenosine(34) deaminase TadA
  • length: 155
  • theoretical pI: 4.55151
  • theoretical MW: 17617.1
  • GRAVY: -0.164516

⊟Function[edit | edit source]

  • reaction:
    EC 3.5.4.33?  ExPASy
    tRNA(adenine34) deaminase Adenine34 in tRNA + H2O = hypoxanthine34 in tRNA + NH3
  • TIGRFAM:
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Riboflavin, FMN, and FAD riboflavin biosynthesis protein RibD (TIGR00326; EC 1.1.1.193,3.5.4.26; HMM-score: 51)
    and 1 more
    ComE operon protein 2 (TIGR02571; HMM-score: 15.9)
  • TheSEED: data available for D39, Hungary19A-6, TIGR4
  • PFAM:
    CDA (CL0109) MafB19-deam; MafB19-like deaminase (PF14437; HMM-score: 121)
    and 7 more
    dCMP_cyt_deam_1; Cytidine and deoxycytidylate deaminase zinc-binding region (PF00383; HMM-score: 90.9)
    SNAD4; Secreted Novel AID/APOBEC-like Deaminase 4 (PF18750; HMM-score: 17.8)
    APOBEC_N; APOBEC-like N-terminal domain (PF08210; HMM-score: 16.3)
    APOBEC4_like; APOBEC4-like -AID/APOBEC-deaminase (PF18774; HMM-score: 16.3)
    Bd3614-deam; Bd3614-like deaminase (PF14439; HMM-score: 14)
    NAD1; Novel AID APOBEC clade 1 (PF18778; HMM-score: 13.6)
    APOBEC2; APOBEC2 (PF18772; HMM-score: 12.8)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9962
    • Cytoplasmic Membrane Score: 0.0004
    • Cell wall & surface Score: 0.0001
    • Extracellular Score: 0.0033
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.001617
    • TAT(Tat/SPI): 0.000305
    • LIPO(Sec/SPII): 0.000504
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000291874 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MYYTLEEKEVFMREALREAEIALEHDEIPIGCVIVKDGEIIGRGHNAREELQRAVMHAEIMAIEDANLSEESWRLLDCTLFVTIEPCVMCSGAIGLARIPNVVYGAKNQKFGAAGSLYDILTDERLNHRVEVETGILEDECAAIMQDFFRNRRKK

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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