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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 09-FEB-2021

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae 6A-10
  • locus tag: HKM25_RS02240 [old locus tag: HKM25_452 ]
  • pan locus tag?: PNEUPAN001318000
  • symbol: HKM25_RS02240
  • pan gene symbol?: ilvB
  • synonym:
  • product: acetolactate synthase large subunit

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: HKM25_RS02240 [old locus tag: HKM25_452 ]
  • symbol: HKM25_RS02240
  • product: acetolactate synthase large subunit
  • replicon: chromosome
  • strand: +
  • coordinates: 420656..422356
  • length: 1701
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NZ_CP053210 (420656..422356) NCBI
  • BioCyc:
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_0404 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    ATGGAGAAAATCAGTTTAGAATCTCCTAAGACGGGGTCGGACCTAGTTTTGGAAACACTT
    CGTGATTTAGGAGTTGATACCATCTTTGGTTATCCTGGTGGTGCGGTTTTGCCTTTTTAT
    GATGCGATATATAATTTTAAAGGCATTCGCCACATTCTAGGGCGCCATGAGCAAGGTTGT
    TTGCATGAAGCTGAAGGTTATGCCAAATCAACTGGAAAGTTGGGTGTTGCCGTCGTCACT
    AGTGGACCAGGAGCAACAAATGCCATTACAGGGATTGCGGATGCTATGAGCGATAGCGTT
    CCCCTTTTGGTCTTTACAGGTCAGGTGGCGCGAGCAGGGATTGGGAAGGATGCCTTTCAG
    GAGGCAGACATCGTAGGAATTACCATGCCAATCACTAAGTACAATTACCAAGTTCGTGAG
    ACAGCTGATATTCCGCGTATCATTACGGAAGCTGTCCATATCGCAACTACAGGCCGTCCA
    GGGCCAGTTGTAATTGACCTACCAAAAGACATATCTGCTTTAGAAACAGACTTCATTTAT
    TCACCAGAAGTGAATTTACCAAGTTATCAGCCGACTGTTGAGCCGAATGATATGCAAATC
    AAGAAAATCTTGAAGCAATTGTCCAAGGCTAAAAAGCCAGTCTTGTTAGCTGGTGGTGGA
    ATTAGTTATGCTGAGGCTGCTACGGAACTAAATGAATTTGCAGAACGCTATCAAATTCCA
    GTGGTAACCAGTCTTTTGGGACAAGGAACGATTGCAACGAGTCACCCACTCTTTCTTGGA
    ATGGGAGGCATGCACGGGTCATTCGCAGCAAATATTGCCATGACGGAAGCGGACTTTATG
    ATTAGTATTGGTTCTCGTTTCGATGACCGTTTGACGGGGAATCCTAAGACTTTCGCTAAG
    AATGCTAAGGTTGCCCACATTGATATTGACCCAGCTGAGATTGGCAAGATTATCAGTGCA
    GACATTCCTGTAGTTGGAGATGCTAAGAAGGCCTTGCAAATGTTGCTAGCAGAACCAACA
    GTTCACAACAATACTGAAAAGTGGATTGAGAAAGTCACTAAAGACAAGAATCGTGTTCGT
    TCTTATGACAAGAAAGAGCGTGTGGTTCAACCGCAAGCAGTTATTGAACGAATTGGTGAA
    TTGACGAATGGAGATGCCATTGTGGTAACAGACGTTGGTCAACACCAAATGTGGACAGCT
    CAGTATTATCCCTACCAAAATGAACGTCAGTTAGTGACTTCAGGTGGTTTGGGAACAATG
    GGCTTTGGAATTCCAGCAGCAATCGGTGCTAAAATTGCTAACCCAGATAAGGAAGTAGTC
    TTGTTTGTTGGGGATGGTGGTTTCCAAATGACTAACCAGGAGTTGGCTATTTTGAATATT
    TACAAGGTGCCAATCAAGGTGGTTATGCTGAACAATCATTCACTCGGAATGGTTCGCCAG
    TGGCAGGAATCCTTCTATGAAGGCAGAACATCAGAGTCGGTCTTTGATATCCTTCCTGAT
    TTCCAATTGATGGCGCAGGCTTATGGTATTAAAAACTATAAGTTTGACAATCCTGAGACC
    TTGGCTCAAGACCTTGAAGTCATCACTGAGGATGTTCCTATGCTAATTGAGGTAGATATT
    TCTCGTAAGGAACAGGTGTTACCAATGGTACCGGCTGGTAAGAGTAATCATGAGATGTTG
    GGGGTGCAGTTCCATGCGTAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1680
    1701

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: HKM25_RS02240 [old locus tag: HKM25_452 ]
  • symbol: HKM25_RS02240
  • description: acetolactate synthase large subunit
  • length: 566
  • theoretical pI: 5.16476
  • theoretical MW: 61689.3
  • GRAVY: -0.095053

⊟Function[edit | edit source]

  • TIGRFAM:
    Metabolism Amino acid biosynthesis Pyruvate family acetolactate synthase, large subunit, biosynthetic type (TIGR00118; EC 2.2.1.6; HMM-score: 779.4)
    and 15 more
    glyoxylate carboligase (TIGR01504; EC 4.1.1.47; HMM-score: 365.8)
    Metabolism Energy metabolism Aerobic pyruvate oxidase (TIGR02720; EC 1.2.3.3; HMM-score: 292.8)
    Metabolism Energy metabolism Fermentation acetolactate synthase, catabolic (TIGR02418; EC 2.2.1.6; HMM-score: 291.4)
    Metabolism Central intermediary metabolism Other sulfoacetaldehyde acetyltransferase (TIGR03457; EC 2.3.3.15; HMM-score: 273.2)
    Metabolism Energy metabolism Sugars 3,5/4-trihydroxycyclohexa-1,2-dione hydrolase (TIGR04377; EC 3.7.1.-; HMM-score: 254.2)
    Cellular processes Cellular processes Detoxification oxalyl-CoA decarboxylase (TIGR03254; EC 4.1.1.8; HMM-score: 202.4)
    indolepyruvate/phenylpyruvate decarboxylase (TIGR03394; EC 4.1.1.43,4.1.1.74; HMM-score: 143.2)
    Metabolism Central intermediary metabolism Other indolepyruvate decarboxylase (TIGR03393; EC 4.1.1.74; HMM-score: 125.6)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Menaquinone and ubiquinone 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase (TIGR00173; EC 2.2.1.9; HMM-score: 58.5)
    phosphonopyruvate decarboxylase (TIGR03297; EC 4.1.1.82; HMM-score: 34.3)
    sulfopyruvate decarboxylase, beta subunit (TIGR03846; EC 4.1.1.79; HMM-score: 31.9)
    2-oxoacid:acceptor oxidoreductase, beta subunit, pyruvate/2-ketoisovalerate family (TIGR02177; HMM-score: 17.6)
    indolepyruvate ferredoxin oxidoreductase, alpha subunit (TIGR03336; EC 1.2.7.8; HMM-score: 14.3)
    Metabolism Energy metabolism Chemoautotrophy CO dehydrogenase/acetyl-CoA synthase complex, epsilon subunit (TIGR00315; EC 1.2.99.2; HMM-score: 13.5)
    Genetic information processing Transcription Transcription factors RNA polymerase sigma factor RpoD (TIGR02393; HMM-score: 11.7)
  • TheSEED: data available for D39, Hungary19A-6, TIGR4
  • PFAM:
    THDP-binding (CL0254) TPP_enzyme_N; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain (PF02776; HMM-score: 187.9)
    FAD_DHS (CL0085) TPP_enzyme_M; Thiamine pyrophosphate enzyme, central domain (PF00205; HMM-score: 161)
    THDP-binding (CL0254) TPP_enzyme_C; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain (PF02775; HMM-score: 155.9)
    and 1 more
    FAD_DHS (CL0085) CO_dh; CO dehydrogenase beta subunit/acetyl-CoA synthase epsilon subunit (PF02552; HMM-score: 13)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 1.05
    • Cytoplasmic Membrane Score: 8.78
    • Cellwall Score: 0.08
    • Extracellular Score: 0.09
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.004205
    • TAT(Tat/SPI): 0.000291
    • LIPO(Sec/SPII): 0.000442
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000411766 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MEKISLESPKTGSDLVLETLRDLGVDTIFGYPGGAVLPFYDAIYNFKGIRHILGRHEQGCLHEAEGYAKSTGKLGVAVVTSGPGATNAITGIADAMSDSVPLLVFTGQVARAGIGKDAFQEADIVGITMPITKYNYQVRETADIPRIITEAVHIATTGRPGPVVIDLPKDISALETDFIYSPEVNLPSYQPTVEPNDMQIKKILKQLSKAKKPVLLAGGGISYAEAATELNEFAERYQIPVVTSLLGQGTIATSHPLFLGMGGMHGSFAANIAMTEADFMISIGSRFDDRLTGNPKTFAKNAKVAHIDIDPAEIGKIISADIPVVGDAKKALQMLLAEPTVHNNTEKWIEKVTKDKNRVRSYDKKERVVQPQAVIERIGELTNGDAIVVTDVGQHQMWTAQYYPYQNERQLVTSGGLGTMGFGIPAAIGAKIANPDKEVVLFVGDGGFQMTNQELAILNIYKVPIKVVMLNNHSLGMVRQWQESFYEGRTSESVFDILPDFQLMAQAYGIKNYKFDNPETLAQDLEVITEDVPMLIEVDISRKEQVLPMVPAGKSNHEMLGVQFHA

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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