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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 24-APR-2025

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae 6A-10
  • locus tag: HKM25_RS05900 [old locus tag: HKM25_1208 ]
  • pan locus tag?: PNEUPAN002510000
  • symbol: leuB
  • pan gene symbol?: leuB
  • synonym:
  • product: 3-isopropylmalate dehydrogenase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: HKM25_RS05900 [old locus tag: HKM25_1208 ]
  • symbol: leuB
  • product: 3-isopropylmalate dehydrogenase
  • replicon: chromosome
  • strand: -
  • coordinates: 1182596..1183633
  • length: 1038
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NZ_CP053210 (1182596..1183633) NCBI
  • BioCyc:
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_1115 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    ATGGCAAAGAAAATAGTAGCTCTAGTAGGAGACGGAATTGGCCCAGAAATCATGGAGGCT
    GGTTTAGAAGTTCTGGAGGCTCTAGCTGAAAAAACAGGTTTTGACTATGAGATTGACAGA
    CGACCGTTCGGAGGTGCAGATATTGATGCAGCAGGACCTCCCTTACCTGATGAAACCCTT
    AAGGCAAGTAGGGAAGCAGATGCTATCCTACTAGCAGCTATCGGTAGTCCTCAGTATGAT
    GGAGCAGCGGTTCGCCCTGAACAAGGCCTGATGGCTCTCCGTAAGGAACTCAATCTTTAC
    GCTAATATTCGTCCTGTAAAAATCTTTGACAGTCTCAAGTATTTGTCACCACTCAAACCG
    GAACGAATTTCTGGCGTAGACTTTGTCGTGGTGCGTGAATTGACAGGCGAGATTTACTTT
    GGAGATCATATTCTTGAAGAGCGCAAAGCGCGTGATATCAACGACTATAGCTATGAGGAA
    GTGGAGCGGATTATTCGCAAAGCCTTTGAAATTGCAAGAAATCGCAGAAAAATCGTTACT
    AGTATCGATAAGCAAAATGTTCTAGCGACCTCAAAACTCTGGCGGAAAGTAGCTGAGGAA
    GTCGCACAGGATTTCCCAGATGTAACCTTGGAACACCAGCTGGTAGACTCAGCTGCTATG
    CTTATGATTACCAATCCTGCTAAGTTTGATGTTATTGTAACGGAGAATCTTTTTGGAGAT
    ATTTTATCTGATGAATCAAGCGTCTTATCTGGTACACTTGGGGTTATGCCATCAGCCAGT
    CATTCTGAAAATGGACCAAGTCTCTATGAACCTATTCACGGTTCAGTACCTGATATTGCA
    GGTCAAGGAATTGCCAATCCTACTTCCATGATTTTATCAGTTGCCATGATGTTAAGAGAT
    AGTTTCGGAGGTTATGAGGATGCAGAGCGTATCAAACGTGCTGTTGAGACAAGTCTGGCG
    GCAGGAATTTTAACGAGAGATATAGGAGGTCAGGCTTCAACAAAGGAAATGACGGAAGCT
    ATTATTGCAAGGTTATGA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1038

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: HKM25_RS05900 [old locus tag: HKM25_1208 ]
  • symbol: LeuB
  • description: 3-isopropylmalate dehydrogenase
  • length: 345
  • theoretical pI: 4.53074
  • theoretical MW: 37630.7
  • GRAVY: -0.0976812

⊟Function[edit | edit source]

  • reaction:
    EC 1.1.1.85?  ExPASy
    3-isopropylmalate dehydrogenase (2R,3S)-3-isopropylmalate + NAD+ = 4-methyl-2-oxopentanoate + CO2 + NADH
  • TIGRFAM:
    Metabolism Amino acid biosynthesis Pyruvate family 3-isopropylmalate dehydrogenase (TIGR00169; EC 1.1.1.85; HMM-score: 451.2)
    and 6 more
    isopropylmalate/isohomocitrate dehydrogenases (TIGR02088; HMM-score: 298.2)
    Metabolism Energy metabolism Other tartrate dehydrogenase (TIGR02089; EC 1.1.1.93; HMM-score: 271.1)
    Metabolism Energy metabolism TCA cycle isocitrate dehydrogenase, NAD-dependent (TIGR00175; EC 1.1.1.41; HMM-score: 186.8)
    Metabolism Energy metabolism TCA cycle isocitrate dehydrogenase (TIGR02924; EC 1.1.1.-; HMM-score: 186.5)
    Metabolism Energy metabolism TCA cycle isocitrate dehydrogenase, NADP-dependent (TIGR00183; EC 1.1.1.42; HMM-score: 119.2)
    Metabolism Central intermediary metabolism Nitrogen metabolism urease, gamma subunit (TIGR00193; EC 3.5.1.5; HMM-score: 12.9)
  • TheSEED: data available for D39, Hungary19A-6
  • PFAM:
    Iso_DH (CL0270) Iso_dh; Isocitrate/isopropylmalate dehydrogenase (PF00180; HMM-score: 429.8)
    and 1 more
    LYR-like (CL0491) Complex1_LYR; Complex 1 protein (LYR family) (PF05347; HMM-score: 12.1)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9928
    • Cytoplasmic Membrane Score: 0.0004
    • Cell wall & surface Score: 0
    • Extracellular Score: 0.0067
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.005611
    • TAT(Tat/SPI): 0.000566
    • LIPO(Sec/SPII): 0.000427
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_001074725 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MAKKIVALVGDGIGPEIMEAGLEVLEALAEKTGFDYEIDRRPFGGADIDAAGPPLPDETLKASREADAILLAAIGSPQYDGAAVRPEQGLMALRKELNLYANIRPVKIFDSLKYLSPLKPERISGVDFVVVRELTGEIYFGDHILEERKARDINDYSYEEVERIIRKAFEIARNRRKIVTSIDKQNVLATSKLWRKVAEEVAQDFPDVTLEHQLVDSAAMLMITNPAKFDVIVTENLFGDILSDESSVLSGTLGVMPSASHSENGPSLYEPIHGSVPDIAGQGIANPTSMILSVAMMLRDSFGGYEDAERIKRAVETSLAAGILTRDIGGQASTKEMTEAIIARL

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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