PangenomeTIGR4

serotype 4

D39

serotype 2

D39V

serotype 2

Hungary19A-6

serotype 19A

EF3030

serotype 19F

670-6B

serotype 6B

6A-10

serotype 6A

70585

serotype 5

A026

serotype 19F

A66

serotype 3

AP200

serotype 11A

ASP0581

serotype 12F

ATCC 49619

serotype 19F

ATCC 700669

serotype 23F

BVJ1JL

serotype 1

CGSP14

serotype 14

G54

serotype 19F

HU-OH

serotype 3

Hu15

serotype 19A

Hu17

serotype 19A

INV104

serotype 1

INV200

serotype 14

JJA

serotype 14

MDRSPN001

serotype 19F

NCTC7466

serotype 2

NU83127

serotype 4

OXC141

serotype 3

P1031

serotype 1

R6

serotype 2

SP49

serotype 19A

SPN032672

serotype 1

SPN034156

serotype 3

SPN034183

serotype 3

SPN994038

serotype 3

SPN994039

serotype 3

SPNA45

serotype 3

ST556

serotype 19F

TCH8431/19A

serotype 19A

Taiwan19F-14

serotype 19F

Xen35

serotype 4

gamPNI0373

serotype 1

NCBI: 24-APR-2024

⊟Summary

• organism: Streptococcus pneumoniae 6A-10
• locus tag: HKM25_RS06140
• pan locus tag^?: PNEUPAN001795000
• symbol: HKM25_RS06140
• pan gene symbol^?: tnp (pseudogene)
• synonym:
• product: IS630 family transposase

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: HKM25_RS06140
• symbol: HKM25_RS06140
• product: IS630 family transposase
• replicon: chromosome
• strand: +
• coordinates: join(1228109..1228543,1228545..1229156)
• length: 1047
• essential: unknown

⊟Accession numbers

• Location: NZ_CP053210 join(1228109..1228543,1228545..1229156) NCBI
• BioCyc:
• MicrobesOnline:
• PneumoBrowse for strain D39V: SPV_2221 PneumoBrowse

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

• 1
  61
  121
  181
  241
  301
  361
  421
  481
  541
  601
  661
  721
  781
  841
  901
  961
  1021
  
  ATGAAATCAACTAAAGAAGAAATCCAAACCATCAAAACACTTTTAAAAGACTCTCGTACA
  GCTAAATATCATAAACGCCTTCAAATCGTTCTATTTCGTCTGATGGGCAAATCTTATAAA
  GAGATTATAGAGCTTTTAGACTGTAATCAAACAACGATTTGGCGAAATGTAAAAAAATAT
  GAGGAGTTCGGACTCGACTCTCTCCTTCAAGAAACACGTGGTGGTCGTAACCATGCATAT
  ATGACAGTTGAGGAAGAGAAAGCCTTTCTTGCCCGTCATTTGAAGGCTACAGAGGCAGGA
  GAATTTGTTACAATTGATGCCTTATTTCAGGCTTATAAAAAGGAGTTAGGCCGTTCCTAC
  ACACGTGATGCCTTCTATCAACTGTTGAAGCGCCATGGTTGGCGAAATATTATGCCACGT
  CCAGAACATCCTAAGAAGCAGACGCTCAAACCATTGTCGCGTCTAAAAATAAAATCTCAA
  TTCAAGAAGAAAAGAAAGCGCTTTAAAACCAGTAGACGTTTTCATAAGGTTCGCTTGATG
  TACCAAGATGAGGCTGGCTTCGGTAGAATCAGTAAACTGGGATCTTGTTGGTCTCCAATA
  GGAGTAGGTCCACATGTCCATAGTCACTATATACGAGAATTTCACTATTGTTATGGAGCT
  GTTGATGCCCATACAGGCGAATCATTTTTCTTAATAGCTGGTGGATGTAATACTGAGTGG
  ATGAACGTCTTTTTAGAAGAGCTTTCACAAGCTTATCCAGATGATTATTTTTTACTCGTT
  ATGGACAATGCTATATGGCATAAATCAAGTATCTTAAAGATTCCGACTAATATTGGCTTT
  GCATTTATTCCTCCATACACACCAGAGATGAACCCCATTGAACAAGTGTGGAAAGAGATT
  CGTAAACGTGGATTTAAGAATAAAGCCTTTCGAACTTCGGAAGATGTCATGAATCAACTT
  CAAGATGTCATACAAGGACTGGAGAAGGAGGTGATAAAGTCCATCGTTAATCGGAGATGG
  ACTAGAATGCTTTTTGAAAGCAGATGA
  60
  120
  180
  240
  300
  360
  420
  480
  540
  600
  660
  720
  780
  840
  900
  960
  1020
  1047
  

⊟Protein

⊟General

• locus tag: HKM25_RS06140
• symbol: HKM25_RS06140
• description: IS630 family transposase
• length: 348
• theoretical pI: 10.3397
• theoretical MW: 41170.5
• GRAVY: -0.596552

⊟Function

• TIGRFAM:
  RNA polymerase sigma factor, sigma-70 family (TIGR02937; HMM-score: 13.7)
• TheSEED:
• PFAM:
  RNase_H (CL0219) DDE_3; DDE superfamily endonuclease (PF13358; HMM-score: 70.6)
  and 13 more
  HTH (CL0123) HTH_33; Winged helix-turn helix (PF13592; HMM-score: 41.4)
  HTH_23; Homeodomain-like domain (PF13384; HMM-score: 36.7)
  HTH_28; Helix-turn-helix domain (PF13518; HMM-score: 33.1)
  HTH_29; Winged helix-turn helix (PF13551; HMM-score: 20.8)
  HTH_32; Homeodomain-like domain (PF13565; HMM-score: 17.5)
  RNase_H (CL0219) DDE_Tnp_IS240; DDE domain (PF13610; HMM-score: 17.4)
  P-loop_NTPase (CL0023) Sulfotransfer_4; Sulfotransferase domain (PF17784; HMM-score: 16.3)
  HTH (CL0123) Sigma70_r4_2; Sigma-70, region 4 (PF08281; HMM-score: 14)
  HTH_38; Helix-turn-helix domain (PF13936; HMM-score: 13.4)
  HTH_11; HTH domain (PF08279; HMM-score: 12.9)
  Terminase_5; Putative ATPase subunit of terminase (gpP-like) (PF06056; HMM-score: 12.8)
  Amidohydrolase (CL0034) RNase_P_p30; RNase P subunit p30 (PF01876; HMM-score: 12.6)
  no clan defined Antimicrobial19; Pseudin antimicrobial peptide (PF08225; HMM-score: 11.9)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• PSORTb: Cytoplasmic
  • Cytoplasmic Score: 7.5
  • Cytoplasmic Membrane Score: 1.15
  • Cellwall Score: 0.62
  • Extracellular Score: 0.73
  • Internal Helices: 0
• SignalP: no predicted signal peptide
  • SP(Sec/SPI): 0.005102
  • TAT(Tat/SPI): 0.000378
  • LIPO(Sec/SPII): 0.001284
• predicted transmembrane helices (TMHMM): 0

⊟Accession numbers

• GI:
• RefSeq: WP_223200684 NCBI
• UniProt:

⊟Protein sequence

• MKSTKEEIQTIKTLLKDSRTAKYHKRLQIVLFRLMGKSYKEIIELLDCNQTTIWRNVKKYEEFGLDSLLQETRGGRNHAYMTVEEEKAFLARHLKATEAGEFVTIDALFQAYKKELGRSYTRDAFYQLLKRHGWRNIMPRPEHPKKQTLKPLSRLKIKSQFKKKRKRFKTSRRFHKVRLMYQDEAGFGRISKLGSCWSPIGVGPHVHSHYIREFHYCYGAVDAHTGESFFLIAGGCNTEWMNVFLEELSQAYPDDYFLLVMDNAIWHKSSILKIPTNIGFAFIPPYTPEMNPIEQVWKEIRKRGFKNKAFRTSEDVMNQLQDVIQGLEKEVIKSIVNRRWTRMLFESR

⊟Experimental data

• protein localization:
• interaction partners:

⊟Expression & Regulation

⊟Operon

⊟Regulation

• regulator:

⊟Expression data

• PneumoExpress for strain D39V: SPV_2221 PneumoExpress

⊟Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊟Other Information

You are kindly invited to share additional interesting facts.

⊟Literature

⊟References

⊟Relevant publications