PangenomeTIGR4

serotype 4

D39

serotype 2

D39V

serotype 2

Hungary19A-6

serotype 19A

EF3030

serotype 19F

670-6B

serotype 6B

6A-10

serotype 6A

70585

serotype 5

A026

serotype 19F

A66

serotype 3

AP200

serotype 11A

ASP0581

serotype 12F

ATCC 49619

serotype 19F

ATCC 700669

serotype 23F

BM6001

serotype 19F

BVJ1JL

serotype 1

CGSP14

serotype 14

G54

serotype 19F

HU-OH

serotype 3

Hu15

serotype 19A

Hu17

serotype 19A

INV104

serotype 1

INV200

serotype 14

JJA

serotype 14

MDRSPN001

serotype 19F

NCTC7465

serotype 1

NCTC7466

serotype 2

NU83127

serotype 4

OXC141

serotype 3

P1031

serotype 1

R6

serotype 2

SP49

serotype 19A

SPN032672

serotype 1

SPN034156

serotype 3

SPN034183

serotype 3

SPN994038

serotype 3

SPN994039

serotype 3

SPNA45

serotype 3

ST556

serotype 19F

TCH8431/19A

serotype 19A

Taiwan19F-14

serotype 19F

Xen35

serotype 4

gamPNI0373

serotype 1

NCBI: 28-AUG-2013

⊟Summary

• organism: Streptococcus pneumoniae TCH8431/19A
• locus tag: HMPREF0837_10502 [new locus tag: HMPREF0837_RS02460 ]
• pan locus tag^?: PNEUPAN000916000
• symbol: HMPREF0837_10502
• pan gene symbol^?: —
• synonym:
• product: sigma-70, region 4

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: HMPREF0837_10502 [new locus tag: HMPREF0837_RS02460 ]
• symbol: HMPREF0837_10502
• product: sigma-70, region 4
• replicon: chromosome
• strand: +
• coordinates: 452138..452674
• length: 537
• essential: unknown

⊟Accession numbers

• Location: CP001993 (452138..452674) NCBI
• BioCyc: see HMPREF0837_RS02460
• MicrobesOnline:
• PneumoBrowse for strain D39V:

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

• 1
  61
  121
  181
  241
  301
  361
  421
  481
  
  ATGGAGAATGGACTTGAACCTAGAGCGAAGCTAGAGAAAATGAAAAAAAGCCAGCACAGG
  GCTGACTCCTTTATGAATTATTCCATAAAACTATTATATCACAAAGGAGGCCGAGGCATG
  ACACCAGAGCAAGTAAAAGAAAAACTAGAGGGCGTTAAGTGGATAAACAAGGAGATCAAA
  GGCTTATATTTGGAATTGGAAACCCTGGAAGGTGGCATTATCAAAAAACCAACACTAAGC
  CATAGCAGGGTGCAGACAAGTAGAGAGAATAAGACAGAGAACAATCTTATAAGTGTTCTG
  AAGCTAAAAGAGGACACTTTACAGAGAATTGAGCGACTTACTGAAGAGAGAATGAAAATA
  TCTGAGCTAATCGATAAACTGGCCAATCCGCTTGAGCGTTCTGTTCTAAGACTTTTTTAC
  TTGAATGATCTTGTAGTTTCGGAGGTGGCTGAAGAAATAGATAGATCAAATACTACAGTA
  TACATTATAAGGCAAAAAGCTATAGAACACTTAACAGGTATTGTAAACGGGGATTGA
  60
  120
  180
  240
  300
  360
  420
  480
  537
  

⊟Protein

⊟General

• locus tag: HMPREF0837_10502 [new locus tag: HMPREF0837_RS02460 ]
• symbol: HMPREF0837_10502
• description: sigma-70, region 4
• length: 178
• theoretical pI: 9.54548
• theoretical MW: 20602.7
• GRAVY: -0.609551

⊟Function

• TIGRFAM:
  RNA polymerase sigma factor, sigma-70 family (TIGR02937; HMM-score: 34.8)
  and 11 more
  RNA polymerase sigma-70 factor, TIGR02954 family (TIGR02954; HMM-score: 23.7)
  RNA polymerase sigma-70 factor, sigma-B/F/G subfamily (TIGR02980; HMM-score: 23.6)
  RNA polymerase sigma-70 factor, Bacteroides expansion family 1 (TIGR02985; HMM-score: 22.6)
  RNA polymerase sigma-70 factor, Planctomycetaceae-specific subfamily 1 (TIGR02984; HMM-score: 22.5)
  RNA polymerase sigma-70 factor, sigma-E family (TIGR02983; HMM-score: 22.2)
  RNA polymerase sigma factor, FliA/WhiG family (TIGR02479; HMM-score: 19.4)
  RNA polymerase sigma-70 factor, TIGR02952 family (TIGR02952; HMM-score: 18.5)
  RNA polymerase sigma-B factor (TIGR02941; HMM-score: 15.8)
  RNA polymerase sigma-70 factor, Rhodopirellula/Verrucomicrobium family (TIGR02989; HMM-score: 14.9)
  Cellular processes Cellular processes Sporulation and germination RNA polymerase sigma-F factor (TIGR02885; HMM-score: 14.4)
  Genetic information processing Transcription Transcription factors RNA polymerase sigma-F factor (TIGR02885; HMM-score: 14.4)
• TheSEED  :
  • Phage protein
• PFAM:
  HTH (CL0123) DUF1492; Protein of unknown function (DUF1492) (PF07374; HMM-score: 41.5)
  and 7 more
  Sigma70_r4; Sigma-70, region 4 (PF04545; HMM-score: 23)
  Sigma70_r4_2; Sigma-70, region 4 (PF08281; HMM-score: 21.5)
  UPF0122; Putative helix-turn-helix protein, YlxM / p13 like (PF04297; HMM-score: 18.7)
  Terminase_5; Putative ATPase subunit of terminase (gpP-like) (PF06056; HMM-score: 16.6)
  PKinase (CL0016) CotH; CotH kinase protein (PF08757; HMM-score: 14.9)
  HTH (CL0123) HTH_23; Homeodomain-like domain (PF13384; HMM-score: 14.4)
  no clan defined Het-C; Heterokaryon incompatibility protein Het-C (PF07217; HMM-score: 12.8)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• PSORTb: Cytoplasmic
  • Cytoplasmic Score: 7.5
  • Cytoplasmic Membrane Score: 1.15
  • Cellwall Score: 0.62
  • Extracellular Score: 0.73
  • Internal Helices: 0
• DeepLocPro: Cytoplasmic
  • Cytoplasmic Score: 0.8684
  • Cytoplasmic Membrane Score: 0.0518
  • Cell wall & surface Score: 0.0084
  • Extracellular Score: 0.0714
• SignalP: no predicted signal peptide
  • SP(Sec/SPI): 0.003522
  • TAT(Tat/SPI): 0.000359
  • LIPO(Sec/SPII): 0.000547
• predicted transmembrane helices (TMHMM): 0

⊟Accession numbers

• GI:
• RefSeq: ADI68730 NCBI
• UniProt:

⊟Protein sequence

• MENGLEPRAKLEKMKKSQHRADSFMNYSIKLLYHKGGRGMTPEQVKEKLEGVKWINKEIKGLYLELETLEGGIIKKPTLSHSRVQTSRENKTENNLISVLKLKEDTLQRIERLTEERMKISELIDKLANPLERSVLRLFYLNDLVVSEVAEEIDRSNTTVYIIRQKAIEHLTGIVNGD

⊟Experimental data

• protein localization:
• interaction partners:

⊟Expression & Regulation

⊟Operon

⊟Regulation

• regulator:

⊟Expression data

• PneumoExpress for strain D39V:

⊟Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊟Other Information

You can add further information about the gene and protein here. [edit]

⊟Literature

⊟References

⊟Relevant publications