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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 28-AUG-2013

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae TCH8431/19A
  • locus tag: HMPREF0837_10617 [new locus tag: HMPREF0837_RS03015 ]
  • pan locus tag?: PNEUPAN001105000
  • symbol: HMPREF0837_10617
  • pan gene symbol?: spnHL
  • synonym:
  • product: LPXTG-motif cell wall anchor domain protein

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: HMPREF0837_10617 [new locus tag: HMPREF0837_RS03015 ]
  • symbol: HMPREF0837_10617
  • product: LPXTG-motif cell wall anchor domain protein
  • replicon: chromosome
  • strand: +
  • coordinates: 553197..555959
  • length: 2763
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    1741
    1801
    1861
    1921
    1981
    2041
    2101
    2161
    2221
    2281
    2341
    2401
    2461
    2521
    2581
    2641
    2701
    2761
    TTGAGGGAAAGTGGTAAGGACAAGCGATTGTGGAATTCTGCAACGACGTCAGGAACAAAG
    GACTGGCAGACCATTGAAGCAGACTATAGCCCGACTTTAGATGTTGATAAAATCAAGCTG
    GAGTTATTCTATGAAACAGGAACTGGGACTGTTTCCTTTAAGGATATTGAGCTGGTAGAG
    GTAGCAGACCAGCCTTCTGAGGATTCTCAAACAGATAAACAGCTTGAGGAAAAGATTGAT
    TTACCAATTGGAAAAAAACATGTTTTTTCTCTTGCGGACTATACTTATAAGGTAGAAAAT
    CCTGACGTTGCTTCAGTCAAAAATGGAATTTTAGAACCTCTTAAGGAAGGGACAACCAAT
    GTCATTGTCAGTAAAGATGGCAAGGAAGTGAAAAAGATTCCTTTGAAGATTCTAGCCTCT
    GTTAAGGATGCATACACAGACCGTTTGGATGACTGGAATGGCATCATCGCTGGGAATCAA
    TACTATGATTCTAAAAATGAACAGATGGCCAAATTAAACCAGGAATTGGAAGGAAAGGTA
    GCTGATAGCCTATCCAGTATTTCAAGTCAGGCGGACCGCATCTATTTGTGGGAAAAATTT
    TCAAATTATAAAACGTCTGCAAATCTGACTGCCACTTATCGGAAATTGGAGGAGATGGCC
    AAGCAAGTGACCAATCCTTCTTCTCGTTATTATCAAGATGAAACTGTCGTTCGAACAGTC
    AGGGATTCCATGGAATGGATGCATAAATATGTCTACAATAGTGAAAAGAGCATTGTTGGG
    AACTGGTGGGATTATGAAATCGGTACACCTCGTGCCATCAACAATACCTTGTCTCTGATG
    AAAGAATACTTCTCTGATGAGGAAATTAAAAAATATACAGATGTGATTGAAAAATTTGTA
    CCAGATCCCGAACATTTCCGAAAGACGACTGATAACCCATTTAAGGCTCTAGGTGGAAAC
    TTAGTTGATATGGGAAGAGTAAAAGTAATAGCTGGTTTACTGCGTAAAGATGATCAAGAA
    ATTTCTTCTACCATTCGCTCGATTGAGCAAGTGTTCAAGTTGGTAGACCAAGGTGAAGGT
    TTTTATCAAGATGGATCCTATATCGACCATACCAATGTTGCCTATACGGGTGCTTATGGG
    AATGTTTTGATTGATGGCCTGTCTCAACTGTTGCCAGTCATTCAAAAGACCAAGAATCCA
    ATCGATAAAGATAAAATGCAAACCATGTACCACTGGATTGATAAATCGTTTGCTCCTTTG
    CTGGTGAATGGAGAGCTGATGGATATGAGTCGTGGACGCTCGATCAGTCGTGCAAATAGC
    GAGGGGCACGTGGCCGCAGTAGAAGTACTAAGAGGGATTCACCGAATAGCGGATATGTCT
    GAAGGAGAAACCAAACAACGTTTGCAGAGTCTTGTGAAGACCATTGTTCAATCGGATAGT
    TATTATGATGTCTTTAAGAATTTGAAGACTTATAAGGATATCAGTTTGATGCAATCCTTG
    TTAAGTGATGCAGGAGTCGCAAGTGTTCCAAGAACAAGTTACCTATCTGCCTTTAACAAG
    ATGGATAAAACAGCCATGTACAATGCAGAGAAAGGGTTTGGATTTGGCTTGTCACTCTTT
    TCCAGTCGTACCTTGAATTACGAACATATGAACAAGGAAAATAAACGTGGTTGGTATACG
    AGTGATGGGATGTTCTATCTTTACAATGGCGATTTGAGTCACTATAGCGATGGCTACTGG
    CCAACAGTCAATCCATATAAGATGCCTGGTACAACAGAGACGGATGCTAAGAGAGCGGAT
    AGCGATACAGGTAAAGTTTTACCGTCTGCTTTCGTTGGAACGAGCAAACTAGATGATGCC
    AATGCGACAGCAACCATGGATTTCACCAACTGGAATCAAACATTGACTGCTCATAAGAGC
    TGGTTTATGCTAAAGGATAAGATCGCCTTTTTAGGAAGCAATATCCAAAACACTTCAACA
    GATACTGCTGCAACTACAATTGACCAGAGAAAACTGGAATCAGGTAATCCATATAAAGTC
    TATGTCAATGATAAAGAAGCCTCCCTTACAGAACAAGAAAAGGATTATCCTGAAACCCAA
    AGTGTCTTTTTAGAATCGTCCGATTCGAAAAAGAATATTGGTTACTTTTTCTTTAAGAAG
    AGTTCAATCAGTATGAGTAAGGCTTTGCAAAAGGGAGCCTGGAAGGATATCAATGAAGGA
    CAGTCAGACAAGGAAGTTGAAAATGAATTTCTTACGATTAGTCAGGCTCATAAGCAAAAT
    GGGGATTCTTATGGCTATATGCTCATCCCTAACGTGGATCGTGCCACCTTCAATCAAATG
    ATAAAAGAGTTAGAAAGTAGCCTCATCGACAATAACGAAACCCTTCAGTCTGTTTATGAT
    GCCAAACAAGGAGTTTGGGGCATTGTGAAATATGATGATTCTGTCTCTACTATTTCCAAC
    CAATTCCAAGTTTTGAAACGTGGAGTCTATATCATTCGAAAAGAAGGGGATGAATATAAG
    ATTGCCTACTATAATCCTGAAACCCAGGAATCAGCTCCAGATCAGGAAGTCTTTAAAAAG
    CTAGAGCAAGCAACTCAGCCACAAGTACAGAATTCAAAAGAAAAGGAAAAATCTGAAGAG
    GAAAAGAACCATTCGGATCAAAAGAATCTCCCTCAGACAGGAGAAGGTCAGTCAATCTTG
    GCAAGTCTAGGGTTCTTGCTACTTGGGGCGTTTTATCTATTCCGTAGAGGAAAGAACAAC
    TAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1680
    1740
    1800
    1860
    1920
    1980
    2040
    2100
    2160
    2220
    2280
    2340
    2400
    2460
    2520
    2580
    2640
    2700
    2760
    2763

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: HMPREF0837_10617 [new locus tag: HMPREF0837_RS03015 ]
  • symbol: HMPREF0837_10617
  • description: LPXTG-motif cell wall anchor domain protein
  • length: 920
  • theoretical pI: 5.17785
  • theoretical MW: 104443
  • GRAVY: -0.685761

⊟Function[edit | edit source]

  • TIGRFAM:
    Cell structure Cell envelope Other LPXTG cell wall anchor domain (TIGR01167; HMM-score: 26.2)
  • TheSEED  :
    • Hyaluronate lyase precursor (EC 4.2.2.1)
    Virulence, Disease and Defense Virulence, Disease and Defense - no subcategory Streptococcus pyogenes Virulome  Hyaluronate lyase precursor (EC 4.2.2.1)
  • PFAM:
    Hy-ly_N (CL0372) Lyase_8_N; Polysaccharide lyase family 8, N terminal alpha-helical domain (PF08124; HMM-score: 432.9)
    and 4 more
    Gal_mutarotase (CL0103) Lyase_8; Polysaccharide lyase family 8, super-sandwich domain (PF02278; HMM-score: 229.6)
    no clan defined Lyase_8_C; Polysaccharide lyase family 8, C-terminal beta-sandwich domain (PF02884; HMM-score: 45.9)
    Gram_pos_anchor; LPXTG cell wall anchor motif (PF00746; HMM-score: 18.4)
    DUF4449; Protein of unknown function (DUF4449) (PF14613; HMM-score: 7.9)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cellwall
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 9.49
    • Extracellular Score: 0.5
    • Internal Helix: 1
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.014425
    • TAT(Tat/SPI): 0.000787
    • LIPO(Sec/SPII): 0.001602
  • predicted transmembrane helices (TMHMM): 1

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MRESGKDKRLWNSATTSGTKDWQTIEADYSPTLDVDKIKLELFYETGTGTVSFKDIELVEVADQPSEDSQTDKQLEEKIDLPIGKKHVFSLADYTYKVENPDVASVKNGILEPLKEGTTNVIVSKDGKEVKKIPLKILASVKDAYTDRLDDWNGIIAGNQYYDSKNEQMAKLNQELEGKVADSLSSISSQADRIYLWEKFSNYKTSANLTATYRKLEEMAKQVTNPSSRYYQDETVVRTVRDSMEWMHKYVYNSEKSIVGNWWDYEIGTPRAINNTLSLMKEYFSDEEIKKYTDVIEKFVPDPEHFRKTTDNPFKALGGNLVDMGRVKVIAGLLRKDDQEISSTIRSIEQVFKLVDQGEGFYQDGSYIDHTNVAYTGAYGNVLIDGLSQLLPVIQKTKNPIDKDKMQTMYHWIDKSFAPLLVNGELMDMSRGRSISRANSEGHVAAVEVLRGIHRIADMSEGETKQRLQSLVKTIVQSDSYYDVFKNLKTYKDISLMQSLLSDAGVASVPRTSYLSAFNKMDKTAMYNAEKGFGFGLSLFSSRTLNYEHMNKENKRGWYTSDGMFYLYNGDLSHYSDGYWPTVNPYKMPGTTETDAKRADSDTGKVLPSAFVGTSKLDDANATATMDFTNWNQTLTAHKSWFMLKDKIAFLGSNIQNTSTDTAATTIDQRKLESGNPYKVYVNDKEASLTEQEKDYPETQSVFLESSDSKKNIGYFFFKKSSISMSKALQKGAWKDINEGQSDKEVENEFLTISQAHKQNGDSYGYMLIPNVDRATFNQMIKELESSLIDNNETLQSVYDAKQGVWGIVKYDDSVSTISNQFQVLKRGVYIIRKEGDEYKIAYYNPETQESAPDQEVFKKLEQATQPQVQNSKEKEKSEEEKNHSDQKNLPQTGEGQSILASLGFLLLGAFYLFRRGKNN

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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