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INV200
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JJA
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NCTC7466
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SPN034183
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SPN994038
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SPNA45
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ST556
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TCH8431/19A
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serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 28-AUG-2013

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae TCH8431/19A
  • locus tag: HMPREF0837_12044 [new locus tag: HMPREF0837_RS09800 ]
  • pan locus tag?: PNEUPAN003337000
  • symbol: trpE
  • pan gene symbol?: trpE
  • synonym:
  • product: anthranilate synthase component I

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: HMPREF0837_12044 [new locus tag: HMPREF0837_RS09800 ]
  • symbol: trpE
  • product: anthranilate synthase component I
  • replicon: chromosome
  • strand: -
  • coordinates: 1872734..1874095
  • length: 1362
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    ATGGAACGAATCATTCATGGAGATGTCTTATCACCAATCTTGGCTTATATGCGCTTAAAG
    GGGCAACACAAGGTTATCTTAGAGAGTATTCCGAGAGACAAGGAAACAGCTCGTTTTTCT
    ATCCTAGCCTATAATCCAATTTTTGAGATTAAGTTTGAAAATGGAGTTCTCTATCAAAAT
    GGTCAAGTGATTGATCGGGATCCCTTGGATTTCCTTTATGAAGTGATTCATAAGAGTCAG
    CACCACTCAGAGCTACCTTTTGGTGGTGGAGCCGTTGGTTTTGTGGGTTACGATATGATT
    TCACTTTATGAAGAAATTGGTCAAATCCCTGAGGATACAATTGGGACGCCAGACATGCAT
    TTCTTTGTCTATGAGAGCTATATGGTCTTTGACCACAAGAAGGAGAAGATACATGTCATA
    GAGGATGCACTTTATAGTGAGCGCAGTCAAGAGGCCTTGGAAAAATCCTTGAACCAAGTG
    CTTGAGGAATTACGCATTCCTGCTCCAAATGAATTTGAAGACTTGGATCTATCTCCGTTA
    GACTTCAAACCTCATATCGCTCCTCAGAAGTTTGAGGAAATGGTGGAAACAGCTCGTGAC
    TTGATTCGTAATGGTGATATGTTCCAATGCGTACTCAGCCAGCGCTTTTCAGCAGAGGTT
    ACTGGAAATCCATTTGACTTCTACAGAAATCTCCGCGTGACCAATCCATCTAATTACCTT
    TATTTCTATGACTTTGGGGATTATCAAATCATCGGTGCCAGTCCAGAAAGTTTGGTTTCT
    GTCAAAAATGGCATCGTGACAACCAATCCGATTGCAGGGACGCGACCAAGAGGGGCTACG
    GATGAAGAAGACAAGACCTTGGCGACTGACCTCCTCTCTGATGAGAAGGAAACAGCAGAA
    CATCGAATGTTGGTAGACTTGGGGCGTAACGATATTGGCCGCATCTCTGAAACGGCCAGT
    GTCCAAGTTACTAAGTATATGGAGGTGGAGCTCTTCCGCTACGTCATGCATTTGACCAGT
    GTGGTCAAGGGACGTTTGCTTGCAGAACTCACTGCCATGGATGCCTTGAAAGCAACGCTT
    CCTGCTGGAACCGTTTCTGGAGCACCAAAGATTCGGGCGATGAGACGCATCTATGAACTG
    GAAACGGAAAAACGGGGCGTATATGCAGGAGCAATCGGCTACTTGTCTGCGACGGGTGAT
    ATGGATTTGGCCATCGCCATCCGAACCATGATTCTCAAAAATCAAAGAGCCTATGTGCAG
    GCTGGGGCAGGGATTGTCTACGACTCTATCGCCCAAAACGAATACCAAGAAACCATTAAC
    AAAGCAAAATCTATGACTAGAATTGGAGAACTAAGACCATGA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1362

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: HMPREF0837_12044 [new locus tag: HMPREF0837_RS09800 ]
  • symbol: TrpE
  • description: anthranilate synthase component I
  • length: 453
  • theoretical pI: 4.88799
  • theoretical MW: 51248
  • GRAVY: -0.280353

⊟Function[edit | edit source]

  • reaction:
    EC 4.1.3.27?  ExPASy
    Anthranilate synthase Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate
  • TIGRFAM:
    Metabolism Amino acid biosynthesis Aromatic amino acid family anthranilate synthase component I (TIGR00564; EC 4.1.3.27; HMM-score: 573.8)
    and 8 more
    Metabolism Amino acid biosynthesis Aromatic amino acid family anthranilate synthase component I (TIGR01820; EC 4.1.3.27; HMM-score: 439.9)
    aminodeoxychorismate synthase, component I (TIGR01824; EC 2.6.1.85; HMM-score: 322)
    Metabolism Amino acid biosynthesis Aromatic amino acid family anthranilate synthase component I (TIGR00565; EC 4.1.3.27; HMM-score: 296.1)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Folic acid aminodeoxychorismate synthase, component I (TIGR00553; EC 2.6.1.85; HMM-score: 291.6)
    Metabolism Amino acid biosynthesis Aromatic amino acid family anthranilate synthase (TIGR01815; EC 4.1.3.27; HMM-score: 204.9)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Menaquinone and ubiquinone isochorismate synthase (TIGR00543; EC 5.4.4.2; HMM-score: 195.1)
    salicylate synthase (TIGR03494; EC 4.1.3.-,5.4.4.2; HMM-score: 180.8)
    aminodeoxychorismate synthase (TIGR01823; EC 2.6.1.85; HMM-score: 177.1)
  • TheSEED  :
    • Anthranilate synthase, aminase component (EC 4.1.3.27)
    Amino Acids and Derivatives Aromatic amino acids and derivatives Tryptophan synthesis  Anthranilate synthase, aminase component (EC 4.1.3.27)
  • PFAM:
    no clan defined Chorismate_bind; chorismate binding enzyme (PF00425; HMM-score: 299.1)
    and 1 more
    Anth_synt_I_N; Anthranilate synthase component I, N terminal region (PF04715; HMM-score: 107.6)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9854
    • Cytoplasmic Membrane Score: 0.0066
    • Cell wall & surface Score: 0.0003
    • Extracellular Score: 0.0077
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.002867
    • TAT(Tat/SPI): 0.000182
    • LIPO(Sec/SPII): 0.000527
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: ADI70272 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MERIIHGDVLSPILAYMRLKGQHKVILESIPRDKETARFSILAYNPIFEIKFENGVLYQNGQVIDRDPLDFLYEVIHKSQHHSELPFGGGAVGFVGYDMISLYEEIGQIPEDTIGTPDMHFFVYESYMVFDHKKEKIHVIEDALYSERSQEALEKSLNQVLEELRIPAPNEFEDLDLSPLDFKPHIAPQKFEEMVETARDLIRNGDMFQCVLSQRFSAEVTGNPFDFYRNLRVTNPSNYLYFYDFGDYQIIGASPESLVSVKNGIVTTNPIAGTRPRGATDEEDKTLATDLLSDEKETAEHRMLVDLGRNDIGRISETASVQVTKYMEVELFRYVMHLTSVVKGRLLAELTAMDALKATLPAGTVSGAPKIRAMRRIYELETEKRGVYAGAIGYLSATGDMDLAIAIRTMILKNQRAYVQAGAGIVYDSIAQNEYQETINKAKSMTRIGELRP

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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