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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 19-SEP-2021

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae TCH8431/19A
  • locus tag: HMPREF0837_RS00220 [old locus tag: HMPREF0837_10041 ]
  • pan locus tag?: PNEUPAN003613000
  • symbol: HMPREF0837_RS00220
  • pan gene symbol?: —
  • synonym:
  • product: class I SAM-dependent methyltransferase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: HMPREF0837_RS00220 [old locus tag: HMPREF0837_10041 ]
  • symbol: HMPREF0837_RS00220
  • product: class I SAM-dependent methyltransferase
  • replicon: chromosome
  • strand: -
  • coordinates: 35474..36427
  • length: 954
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NC_014251 (35474..36427) NCBI
  • BioCyc: HMPREF0837_RS00220 BioCyc
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_1854 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    ATGGATTTTGAAAAAATTGAACAAGCTTATACCTATTTACTAGAGAATGTCCAAGTCATC
    CAAAGTGATTTGGCGACCAACTTTTATGACGCCTTGGTGGAGCAAAACAGCATCTATCTG
    GATGGTGAAACTGAGCTAAACCAGGTCAAAGACAACAATCAGGCCCTTAAGCGTTTAGCA
    CTACGCAAAGAAGAATGGCTCAAGACCTACCAGTTTCTCTTGATGAAGGCTGGGCAAACA
    GAACCCTTGCAGGCCAATCACCAGTTTACACCAGATGCCATTGCTTTGCTTTTGGTGTTT
    ATTGTGGAAGAGTTGTTTAAAGAGGAGGAAATTACTATCCTCGAAATGGGTTCTGGGATG
    GGAATTCTAGGCGCTACTTTCTTGACCTCGCTTGATAAAAAGGTGGATTACTTGGGAATG
    GAAATGGATGATTTGCTGATTGATCTGGCAGCTAGCATGGCAGATGTAATTGGTTTGCAG
    GCTGGCTTTGTCCAAGGAGATGCCGTTCGTCCACAAATGCTCAAAGAAAGCGATGTGGTC
    ATCAGTGACTTGCCTGTTGGCTATTATCCTGATGATGCCGTTGCGTCGCGCCATCAAGTT
    GCTTCTAGCCAAGAACATACTTACGCCCATCACTTGCTCATGGAACAAGGGCTTAAGTAC
    CTCAAGTCAGACGGATACGCTATTTTTCTAGCTCCGAGTGATTTGTTGACCAGTCCTCAA
    AGTGATTTGTTAAAAGAATGGCTGAAAGAAGAGGCGAGTCTGGTTGCTATGATTAGTCTG
    CCTGAAAATCTCTTTGCTAATGCCAAACAATCTAAGACTATTTTTATCTTACAGAAGAAA
    AATGAAATAGCAGTAGAGCCTTTTGTTTATCCACTTGCTAGCTTGCAAGATGCAAGTGTT
    TTAATGAAATTTAAAGAAAATTTTCAAAAATGGACTCAAGGTACTGAAATATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    954

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: HMPREF0837_RS00220 [old locus tag: HMPREF0837_10041 ]
  • symbol: HMPREF0837_RS00220
  • description: class I SAM-dependent methyltransferase
  • length: 317
  • theoretical pI: 4.2434
  • theoretical MW: 35746.7
  • GRAVY: -0.0835962

⊟Function[edit | edit source]

  • TIGRFAM:
    Genetic information processing DNA metabolism Restriction/modification type II restriction m6 adenine DNA methyltransferase, Alw26I/Eco31I/Esp3I family (TIGR02987; EC 2.1.1.72; HMM-score: 20.8)
    Genetic information processing Protein fate Protein modification and repair protein-(glutamine-N5) methyltransferase, release factor-specific (TIGR03534; EC 2.1.1.-; HMM-score: 19.9)
    Genetic information processing Protein synthesis tRNA and rRNA base modification ribosomal RNA small subunit methyltransferase A (TIGR00755; EC 2.1.1.182; HMM-score: 18.6)
    and 4 more
    Genetic information processing DNA metabolism Restriction/modification type I restriction-modification system, M subunit (TIGR00497; EC 2.1.1.72; HMM-score: 16.3)
    Genetic information processing Protein synthesis tRNA and rRNA base modification tRNA (guanine-N(7)-)-methyltransferase (TIGR00091; EC 2.1.1.33; HMM-score: 16.2)
    Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides putative sugar O-methyltransferase (TIGR04371; EC 2.1.1.-; HMM-score: 14.8)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Biotin malonyl-acyl carrier protein O-methyltransferase BioC (TIGR02072; EC 2.1.1.-; HMM-score: 14.7)
  • TheSEED: see HMPREF0837_10041
  • PFAM:
    NADP_Rossmann (CL0063) N6_Mtase; N-6 DNA Methylase (PF02384; HMM-score: 37.4)
    and 7 more
    Methyltransf_31; Methyltransferase domain (PF13847; HMM-score: 21)
    MTS; Methyltransferase small domain (PF05175; HMM-score: 19.2)
    Methyltransf_25; Methyltransferase domain (PF13649; HMM-score: 18.4)
    Methyltransf_32; Methyltransferase domain (PF13679; HMM-score: 13.8)
    RrnaAD; Ribosomal RNA adenine dimethylase (PF00398; HMM-score: 12.2)
    Methyltransf_16; Lysine methyltransferase (PF10294; HMM-score: 12.1)
    PCMT; Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) (PF01135; HMM-score: 11.9)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 0.32
    • Cytoplasmic Membrane Score: 9.55
    • Cellwall Score: 0.12
    • Extracellular Score: 0.01
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.002954
    • TAT(Tat/SPI): 0.000159
    • LIPO(Sec/SPII): 0.00046
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MDFEKIEQAYTYLLENVQVIQSDLATNFYDALVEQNSIYLDGETELNQVKDNNQALKRLALRKEEWLKTYQFLLMKAGQTEPLQANHQFTPDAIALLLVFIVEELFKEEEITILEMGSGMGILGATFLTSLDKKVDYLGMEMDDLLIDLAASMADVIGLQAGFVQGDAVRPQMLKESDVVISDLPVGYYPDDAVASRHQVASSQEHTYAHHLLMEQGLKYLKSDGYAIFLAPSDLLTSPQSDLLKEWLKEEASLVAMISLPENLFANAKQSKTIFILQKKNEIAVEPFVYPLASLQDASVLMKFKENFQKWTQGTEI

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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