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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 19-SEP-2021

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae TCH8431/19A
  • locus tag: HMPREF0837_RS01125 [old locus tag: HMPREF0837_10220 ]
  • pan locus tag?: PNEUPAN003911000
  • symbol: HMPREF0837_RS01125
  • pan gene symbol?: comFC
  • synonym:
  • product: ComF family protein

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: HMPREF0837_RS01125 [old locus tag: HMPREF0837_10220 ]
  • symbol: HMPREF0837_RS01125
  • product: ComF family protein
  • replicon: chromosome
  • strand: -
  • coordinates: 213097..213759
  • length: 663
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NC_014251 (213097..213759) NCBI
  • BioCyc: HMPREF0837_RS01125 BioCyc
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_2034 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    ATGAAGTGCTTGTTATGTGGGCAGACTATGAAGACTGTTTTAACTTTTAGTAGTCTCTTA
    CTTCTGAGGAATGATGACTCTTGTCTTTGTTCAGACTGTGATTCTACTTTTGAAAGAATT
    GGGGAAGAGAACTGTCCAAATTGTATGAAAACAGAGTTGTCAACAAAGTGTCAAGATTGT
    CAATTTTGGTGTAAAGAAGGAGTTGGAGTCAGTCATAGAGCGATTTTTACTTACAATCAA
    GCTATGAAGGATTTTTTCAGTCGGTATAAGTTTGATGGAGACTTCCTGTTAAGAAAAGTT
    TTCGCTTCATTTTTAAGTGAGGAGTTGAAAAAGTACAAAGAGTATCAATTTGTTGTAATT
    CCCCTAAGTCCTGATAGATATGCTAATAGAGGATTTAATCAGGTTGAGGGCTTGGTAGAG
    GCAGCAGGCTTTGAGTATCTGGATTTATTAGAGAAAAGAGAAGAGAGAGCCAGTTCTTCT
    AAAAATCGTTCAGAGCGCTTGGGGACAGAACTTCCTTTCTTTATTAAAAGTGGAGTCACT
    ATTCCTAAAAAAATCCTACTTATAGATGATATCTATACTACAGGAGCAACTATAAATCGT
    GTTAAGAAACTGTTGGAAGAAGCTGGTGCTAAGGATGTAAAAACATTTTCCCTTGTAAGA
    TGA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    663

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: HMPREF0837_RS01125 [old locus tag: HMPREF0837_10220 ]
  • symbol: HMPREF0837_RS01125
  • description: ComF family protein
  • length: 220
  • theoretical pI: 7.85135
  • theoretical MW: 25202.9
  • GRAVY: -0.279091

⊟Function[edit | edit source]

  • TIGRFAM:
    Cellular processes Cellular processes DNA transformation comF family protein (TIGR00201; HMM-score: 98.2)
    and 5 more
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Salvage of nucleosides and nucleotides hypoxanthine phosphoribosyltransferase (TIGR01203; EC 2.4.2.8; HMM-score: 24.6)
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Purine ribonucleotide biosynthesis ribose-phosphate diphosphokinase (TIGR01251; EC 2.7.6.1; HMM-score: 22.5)
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Pyrimidine ribonucleotide biosynthesis orotate phosphoribosyltransferase (TIGR00336; EC 2.4.2.10; HMM-score: 18.5)
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Salvage of nucleosides and nucleotides adenine phosphoribosyltransferase (TIGR01090; EC 2.4.2.7; HMM-score: 18.2)
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Pyrimidine ribonucleotide biosynthesis orotate phosphoribosyltransferase (TIGR01367; EC 2.4.2.10; HMM-score: 16.3)
  • TheSEED: see HMPREF0837_10220
  • PFAM:
    PRTase-like (CL0533) Pribosyltran; Phosphoribosyl transferase domain (PF00156; HMM-score: 31.1)
    and 4 more
    Zn_Beta_Ribbon (CL0167) DZR_2; Double zinc ribbon domain (PF18912; HMM-score: 14.3)
    PRTase-like (CL0533) PRTase_2; Phosphoribosyl transferase (PF15609; HMM-score: 11.4)
    RING (CL0229) zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger) (PF13920; HMM-score: 8)
    no clan defined HypA; Hydrogenase/urease nickel incorporation, metallochaperone, hypA (PF01155; HMM-score: 7)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • SignalP: Signal peptide SP(Sec/SPI) length 30 aa
    • SP(Sec/SPI): 0.705976
    • TAT(Tat/SPI): 0.0037
    • LIPO(Sec/SPII): 0.10948
    • Cleavage Site: CS pos: 30-31. CLC-SD. Pr: 0.5112
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MKCLLCGQTMKTVLTFSSLLLLRNDDSCLCSDCDSTFERIGEENCPNCMKTELSTKCQDCQFWCKEGVGVSHRAIFTYNQAMKDFFSRYKFDGDFLLRKVFASFLSEELKKYKEYQFVVIPLSPDRYANRGFNQVEGLVEAAGFEYLDLLEKREERASSSKNRSERLGTELPFFIKSGVTIPKKILLIDDIYTTGATINRVKKLLEEAGAKDVKTFSLVR

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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