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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 25-OCT-2024

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae TCH8431/19A
  • locus tag: HMPREF0837_RS02835 [old locus tag: HMPREF0837_10580 ]
  • pan locus tag?: PNEUPAN000999000
  • symbol: HMPREF0837_RS02835
  • pan gene symbol?: proS
  • synonym:
  • product: proline--tRNA ligase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: HMPREF0837_RS02835 [old locus tag: HMPREF0837_10580 ]
  • symbol: HMPREF0837_RS02835
  • product: proline--tRNA ligase
  • replicon: chromosome
  • strand: +
  • coordinates: 511531..513384
  • length: 1854
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

  • Location: NC_014251 (511531..513384) NCBI
  • BioCyc: HMPREF0837_RS02835 BioCyc
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_0246 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    1741
    1801
    ATGAAACAAAGTAAAATGCCTATCCCAACGCTTCGCGAAATGCCAAGCGATGCTCAAGTT
    ATCAGCCATGCTCTTATGTTGCGTGCTGGTTATGTTCGCCAAGTTTCAGCAGGTGTTTAT
    TCTTATCTACCACTTGCCAACCGTGTGATTGAAAAAGCTAAAAACATCATGCGCCAAGAA
    TTCGAAAAGATTGGTGCTGTTGAGATGTTGGCTCCTGCCCTTCTTAGTGCAGAATTGTGG
    CGTGAATCAGGTCGTTACGAAACCTATGGTGAAGACCTTTACAAACTAAAAAACCGTGAA
    AAATCAGACTTTATCTTAGGTCCAACTCACGAAGAAACCTTTACAGCTATTGTCCGTGAT
    TCTGTTAAATCTTACAAGCAATTGCCACTCAACCTTTATCAAATTCAGCCCAAGTATCGT
    GATGAAAAACGCCCACGTAATGGACTTCTTCGTACACGTGAGTTTATCATGAAGGATGCT
    TATAGTTTCCACGCTAACTATGATAGTTTGGATAGTGTTTATGATGAGTACAAAGCAGCC
    TATGAGCGTATTTTCACTCGTAGTGGTTTAGACTTCAAGGCTATTATTGGTGACGGTGGA
    GCCATGGGTGGTAAGGATAGCCAAGAATTTATGGCCATTACATCTGCTCGTACAGACCTT
    GACCGCTGGGTTGTCTTGGACAAGTCAGTTGCCTCATTTGACGAAATTCCTGCAGAAGTG
    CAAGAAGAAATCAAGGCAGAATTGCTCAAATGGATAGTCTCTGGTGAAGATACCATTGCT
    TACTCAAGTGAGTCTAGCTATGCAGCTAACTTAGAAATGGCAACAAACGAGTACAAACCA
    AGCAACCGTGTTGTCGCTGAAGAAGAAGTTACTCGTGTTGCAACGCCAGATGTTAAATCA
    ATTGATGAAGTTGCAGCTTTCCTCAATGTTCCAGAAGAACAAACGATTAAAACCCTCTTC
    TACATTGCAGATGGTGAGCTTGTTGCAGCCCTTCTAGTTGGAAATGACCAACTCAACGAA
    GTCAAGTTGAAAAACCACTTGGGAGCAGATTTCTTTGACGTTGCTAGCGAAGAAGAAGTG
    GCGAATGTTGTTCAAGCAGGATTTGGTTCACTTGGACCAGTTGGTTTGCCAGAGAATATT
    AAAATTATTGCAGATCGTAAGGTGCAAGATGTTCGCAATGCAGTTGTCGGTGCTAACGAA
    GATGGCTACCACTTGACTGGTGTGAACCCAGGCCGTGATTTTACTGCAGAATATGTGGAT
    ATCCGTGAAGTTCGTGAGGGTGAAATTTCCCCAGATGGACAAGGTGTCCTTAACTTTGCG
    CGTGGTATTGAGATCGGTCATATTTTCAAACTCGGAACTCGCTACTCAGCAAGCATGGGA
    GCAGATGTTTTGGATGAAAATGGTCGTGCTGTGCCAATCATCATGGGATGTTACGGTATC
    GGTGTCAGCCGTCTTCTTTCAGCAGTGATGGAGCAACACGCTCGCCTCTTTGTTAACAAA
    ACGCCAAAAGGTGAATACCGTTACGCTTGGGGAATCAATTTCCCTAAAGAATTGGCACCA
    TTTGATGTGCATTTGATTACTGTCAATGTCAAGGATGAAGAAGCGCAAGCCTTGACAGAA
    AAACTTGAAGCAAGCTTGATGGGAGCTGGTTATGAAGTCTTGACAGATGACCGTAACGAA
    CGTGTCGGTGTTAAATTTAGCGATAGTGACTTGATTGGTCTTCCAATCCGTATCACTGTT
    GGTAAAAAAGCGGCCGATGGCATTGTAGAAGTTAAGATCAAGGCAACTGGTGACACCATT
    GAGGTTCATGCAGATAACGTGCTTGAAACGCTTGAAATCCTAAGCAAGAAATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1680
    1740
    1800
    1854

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: HMPREF0837_RS02835 [old locus tag: HMPREF0837_10580 ]
  • symbol: HMPREF0837_RS02835
  • description: proline--tRNA ligase
  • length: 617
  • theoretical pI: 4.73277
  • theoretical MW: 68594.3
  • GRAVY: -0.269044

⊟Function[edit | edit source]

  • reaction:
    EC 6.1.1.15?  ExPASy
    Proline--tRNA ligase ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro)
  • TIGRFAM:
    Genetic information processing Protein synthesis tRNA aminoacylation proline--tRNA ligase (TIGR00409; EC 6.1.1.15; HMM-score: 640.1)
    and 6 more
    Genetic information processing Protein synthesis tRNA aminoacylation threonine--tRNA ligase (TIGR00418; EC 6.1.1.3; HMM-score: 99.6)
    Genetic information processing Protein synthesis tRNA aminoacylation proline--tRNA ligase (TIGR00408; EC 6.1.1.15; HMM-score: 95.7)
    Genetic information processing Protein synthesis tRNA aminoacylation glycine--tRNA ligase (TIGR00389; EC 6.1.1.14; HMM-score: 49)
    Genetic information processing Protein synthesis tRNA aminoacylation histidine--tRNA ligase (TIGR00442; EC 6.1.1.21; HMM-score: 34.7)
    Genetic information processing Protein synthesis tRNA aminoacylation serine--tRNA ligase (TIGR00414; EC 6.1.1.11; HMM-score: 29.7)
    Genetic information processing Protein synthesis tRNA aminoacylation Cys-tRNA(Pro) deacylase (TIGR00011; EC 3.6.1.-; HMM-score: 22.2)
  • TheSEED: see HMPREF0837_10580
  • PFAM:
    tRNA_synt_II (CL0040) tRNA-synt_2b; tRNA synthetase class II core domain (G, H, P, S and T) (PF00587; HMM-score: 198.4)
    and 4 more
    no clan defined tRNA_edit; Aminoacyl-tRNA editing domain (PF04073; HMM-score: 102.3)
    IIaaRS-ABD (CL0458) HGTP_anticodon; Anticodon binding domain (PF03129; HMM-score: 61.4)
    tRNA_synt_II (CL0040) tRNA-synt_2; tRNA synthetases class II (D, K and N) (PF00152; HMM-score: 17.9)
    no clan defined DUF1015; Protein of unknown function (DUF1015) (PF06245; HMM-score: 11.6)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 10
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0
    • Extracellular Score: 0
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9924
    • Cytoplasmic Membrane Score: 0.0002
    • Cell wall & surface Score: 0.0002
    • Extracellular Score: 0.0072
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.005921
    • TAT(Tat/SPI): 0.002865
    • LIPO(Sec/SPII): 0.001084
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000814070 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MKQSKMPIPTLREMPSDAQVISHALMLRAGYVRQVSAGVYSYLPLANRVIEKAKNIMRQEFEKIGAVEMLAPALLSAELWRESGRYETYGEDLYKLKNREKSDFILGPTHEETFTAIVRDSVKSYKQLPLNLYQIQPKYRDEKRPRNGLLRTREFIMKDAYSFHANYDSLDSVYDEYKAAYERIFTRSGLDFKAIIGDGGAMGGKDSQEFMAITSARTDLDRWVVLDKSVASFDEIPAEVQEEIKAELLKWIVSGEDTIAYSSESSYAANLEMATNEYKPSNRVVAEEEVTRVATPDVKSIDEVAAFLNVPEEQTIKTLFYIADGELVAALLVGNDQLNEVKLKNHLGADFFDVASEEEVANVVQAGFGSLGPVGLPENIKIIADRKVQDVRNAVVGANEDGYHLTGVNPGRDFTAEYVDIREVREGEISPDGQGVLNFARGIEIGHIFKLGTRYSASMGADVLDENGRAVPIIMGCYGIGVSRLLSAVMEQHARLFVNKTPKGEYRYAWGINFPKELAPFDVHLITVNVKDEEAQALTEKLEASLMGAGYEVLTDDRNERVGVKFSDSDLIGLPIRITVGKKAADGIVEVKIKATGDTIEVHADNVLETLEILSKK

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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