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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 19-SEP-2021

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae TCH8431/19A
  • locus tag: HMPREF0837_RS04990 [old locus tag: HMPREF0837_11037 ]
  • pan locus tag?: PNEUPAN001716000
  • symbol: HMPREF0837_RS04990
  • pan gene symbol?: guaB_1
  • synonym:
  • product: CBS domain-containing protein

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: HMPREF0837_RS04990 [old locus tag: HMPREF0837_11037 ]
  • symbol: HMPREF0837_RS04990
  • product: CBS domain-containing protein
  • replicon: chromosome
  • strand: +
  • coordinates: 953702..954358
  • length: 657
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NC_014251 (953702..954358) NCBI
  • BioCyc: HMPREF0837_RS04990 BioCyc
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_0657 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    ATGGCAGTTAAAGATTTTATGACCCGCAAGGTAGTTTATATTAGTCCAGATACAACAGTA
    TCTCATGCAGCAGATTTGATGAGAGAGCAAGGTTTGCACCGTCTGCCTGTTATCGAAAAT
    GATCAATTAGTTGGTTTGGTGACTGAGGGAACCATTGCACAAGCAAGTCCATCTAAAGCA
    ACAAGTCTTTCTATCTATGAGATGAATTATCTTCTGAATAAGACAAAAGTAAAAGATGTC
    ATGATTCGCGATGTTGTCACTGTCTCAGGCTATGCTAGTCTAGAAGATGCAACTTATCTG
    ATGTTGAAAAATAAGATTGGTATTCTCCCTGTCGTAGATAACTATCAAGTATACGGAGTT
    ATTACTGACCGTGATGTTTTCCAAGCCTTTCTTGAAATTGCAGGTTATGGCGAAGAAGGG
    ATTCGTGTACGCTTTGTTACAGAAGATGAAGTTGGTGTTCTTGGAAAAATTGTTTCTTTG
    ATTGTAGAAGAAAATTTGAATATCTCCCATACAGTCAATATTCCGCGTAAGGATGGTAAG
    GTGATTATCGAAGTGCAAATCGATGAATCAATTGATTTACCAGCCTTGAAAGAAAAATTT
    GAAGCAAATGGTATTCAAGTGGAAGAAATCGCTCGCACTTCAGCAAAAGTCTTGTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    657

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: HMPREF0837_RS04990 [old locus tag: HMPREF0837_11037 ]
  • symbol: HMPREF0837_RS04990
  • description: CBS domain-containing protein
  • length: 218
  • theoretical pI: 4.65972
  • theoretical MW: 24184.7
  • GRAVY: 0.0633028

⊟Function[edit | edit source]

  • TIGRFAM:
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Purine ribonucleotide biosynthesis inosine-5'-monophosphate dehydrogenase (TIGR01302; EC 1.1.1.205; HMM-score: 46.5)
    Metabolism Energy metabolism Sugars sugar isomerase, KpsF/GutQ family (TIGR00393; HMM-score: 41.7)
    and 5 more
    Metabolism Amino acid biosynthesis Serine family cystathionine beta-synthase (TIGR01137; EC 4.2.1.22; HMM-score: 32.6)
    Metabolism Transport and binding proteins Amino acids, peptides and amines glycine betaine/L-proline transport ATP binding subunit (TIGR01186; HMM-score: 30.1)
    Metabolism Transport and binding proteins Cations and iron carrying compounds magnesium transporter (TIGR00400; HMM-score: 22.5)
    Unknown function General IMP dehydrogenase family protein (TIGR01303; HMM-score: 18.9)
    Metabolism Amino acid biosynthesis Serine family phosphoglycerate dehydrogenase (TIGR01327; EC 1.1.1.95; HMM-score: 15.3)
  • TheSEED: see HMPREF0837_11037
  • PFAM:
    no clan defined CBS; CBS domain (PF00571; HMM-score: 98.3)
    and 2 more
    ACT (CL0070) ACT_4; ACT domain (PF13291; HMM-score: 19.5)
    ACT; ACT domain (PF01842; HMM-score: 18.7)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.016328
    • TAT(Tat/SPI): 0.004067
    • LIPO(Sec/SPII): 0.000418
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MAVKDFMTRKVVYISPDTTVSHAADLMREQGLHRLPVIENDQLVGLVTEGTIAQASPSKATSLSIYEMNYLLNKTKVKDVMIRDVVTVSGYASLEDATYLMLKNKIGILPVVDNYQVYGVITDRDVFQAFLEIAGYGEEGIRVRFVTEDEVGVLGKIVSLIVEENLNISHTVNIPRKDGKVIIEVQIDESIDLPALKEKFEANGIQVEEIARTSAKVL

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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