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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 25-OCT-2024

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae TCH8431/19A
  • locus tag: HMPREF0837_RS08620 [old locus tag: HMPREF0837_11799 ]
  • pan locus tag?: PNEUPAN002848000
  • symbol: HMPREF0837_RS08620
  • pan gene symbol?: yumC
  • synonym:
  • product: NAD(P)/FAD-dependent oxidoreductase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: HMPREF0837_RS08620 [old locus tag: HMPREF0837_11799 ]
  • symbol: HMPREF0837_RS08620
  • product: NAD(P)/FAD-dependent oxidoreductase
  • replicon: chromosome
  • strand: +
  • coordinates: 1656628..1657596
  • length: 969
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NC_014251 (1656628..1657596) NCBI
  • BioCyc: HMPREF0837_RS08620 BioCyc
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_1393 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    ATGTCTCAACTCTATGATATTACCATTGTGGGTGGTGGTCCTGTCGGGCTTTTTGCAGCC
    TTTTATGCCCACCTACGCCAAGCCAAGGTTCAAATCATCGACTCTCTTCCCCAGCTAGGT
    GGACAACCTGCTATTCTCTACCCTGAAAAGGAAATCCTAGACGTACCAGGCTTCCCAAAC
    CTGACTGGAGAAGAGTTGACTAACCGCTTGATTGAACAGCTAAATGGATTTGATACCCCT
    ATTCATCTCAATGAAACGGTTCTTGAGATTGACAAACAAGAAGAAGAATTTGCCATCACA
    ACTTCTAAAGGAAGTCACCTGACTAAAACAGTCATCATCGCTATGGGTGGCGGTGCCTTC
    AAACCACGTCCGCTGGAACTTGAAGGTGTTGAGGGCTATGAAAATATCCACTACCACGTT
    TCTAACATTCAGCAATACGCTGGTAAGAAAGTGACGATTCTTGGTGGGGGAGACTCGGCT
    GTGGATTGGGCTTTGGCTTTTGAAAAAATCGCACCAACTACCCTTGTTCACCGCAGAGAT
    AATTTCCGTGCCTTGGAACACAGTGTTCAAGCCTTGCAAGAATCATCTGTAACCATCAAG
    ACACCATTCGCCCCTAGCCAACTCCTTGGAAATGGAAAAACACTTGATAAACTTGAAATC
    ACAAAAGTCAAATCTGATGAAACTGAAACCATTGACCTAGACCACCTCTTTGTCAACTAT
    GGTTTCAAATCTTCTGTCGGTAACCTTAAAAACTGGGGGCTCAACCTCAACCGTCACAAG
    ATTATCGTCAACAGCAAACAGGAATCCAGCCAAGCAGGTATCTATGCTATCGGTGACTGC
    TGCTACTATGACGGAAAAATTGATCTGATTGCGACAGGCCTCGGAGAAGCTCCAACTGCT
    GTCAACAACGCTATCAACTACATTGACCCTGAACAAAAAGTACAACCAAAACACTCTACC
    AGTTTATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    969

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: HMPREF0837_RS08620 [old locus tag: HMPREF0837_11799 ]
  • symbol: HMPREF0837_RS08620
  • description: NAD(P)/FAD-dependent oxidoreductase
  • length: 322
  • theoretical pI: 5.37393
  • theoretical MW: 35268.7
  • GRAVY: -0.224534

⊟Function[edit | edit source]

  • reaction:
    EC 1.-.-.-?  ExPASy
  • TIGRFAM:
    Metabolism Energy metabolism Electron transport thioredoxin-disulfide reductase (TIGR01292; EC 1.8.1.9; HMM-score: 143.4)
    Cellular processes Cellular processes Detoxification alkyl hydroperoxide reductase subunit F (TIGR03140; EC 1.8.1.-; HMM-score: 116.2)
    Cellular processes Cellular processes Adaptations to atypical conditions alkyl hydroperoxide reductase subunit F (TIGR03140; EC 1.8.1.-; HMM-score: 116.2)
    and 31 more
    Unknown function Enzymes of unknown specificity putative bacillithiol system oxidoreductase, YpdA family (TIGR04018; EC 1.8.-.-; HMM-score: 79)
    putative alkyl hydroperoxide reductase F subunit (TIGR03143; EC 1.6.4.-; HMM-score: 74.3)
    dihydrolipoyl dehydrogenase (TIGR01350; EC 1.8.1.4; HMM-score: 58.7)
    Cellular processes Cellular processes Detoxification mercury(II) reductase (TIGR02053; EC 1.16.1.1; HMM-score: 45.6)
    Unknown function Enzymes of unknown specificity flavoprotein, HI0933 family (TIGR00275; HMM-score: 41.8)
    Metabolism Energy metabolism Electron transport glutathione-disulfide reductase (TIGR01421; EC 1.8.1.7; HMM-score: 38.9)
    putative selenate reductase, YgfK subunit (TIGR03315; HMM-score: 35.4)
    Cellular processes Cellular processes Detoxification CoA-disulfide reductase (TIGR03385; EC 1.8.1.14; HMM-score: 35)
    Metabolism Energy metabolism Electron transport glutathione-disulfide reductase (TIGR01424; EC 1.8.1.7; HMM-score: 32)
    Metabolism Amino acid biosynthesis Glutamate family glutamate synthase (NADPH), homotetrameric (TIGR01316; EC 1.4.1.13; HMM-score: 30.7)
    mycothione reductase (TIGR03452; EC 1.8.1.15; HMM-score: 29.1)
    Metabolism Central intermediary metabolism Nitrogen metabolism nitrite reductase [NAD(P)H], large subunit (TIGR02374; EC 1.7.1.4; HMM-score: 28.3)
    glutamate synthase, small subunit (TIGR01318; HMM-score: 24.9)
    Metabolism Energy metabolism Amino acids and amines sarcosine oxidase, alpha subunit family (TIGR01372; HMM-score: 24.6)
    thioredoxin and glutathione reductase (TIGR01438; EC 1.6.4.-; HMM-score: 23)
    pyridine nucleotide-disulfide oxidoreductase family protein (TIGR03169; HMM-score: 22.7)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Thiamine glycine oxidase ThiO (TIGR02352; EC 1.4.3.19; HMM-score: 20.2)
    FAD dependent oxidoreductase TIGR03364 (TIGR03364; HMM-score: 20.1)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Menaquinone and ubiquinone ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family (TIGR01988; EC 1.14.13.-; HMM-score: 17.9)
    mycofactocin system FadH/OYE family oxidoreductase 2 (TIGR03997; EC 1.-.-.-; HMM-score: 17.8)
    squalene-associated FAD-dependent desaturase (TIGR03467; HMM-score: 17.6)
    flavin-dependent oxidoreductase, MSMEG_0569 family (TIGR04046; HMM-score: 17.2)
    Genetic information processing Protein synthesis tRNA and rRNA base modification tRNA U-34 5-methylaminomethyl-2-thiouridine biosynthesis protein MnmC, C-terminal domain (TIGR03197; HMM-score: 16.5)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Thiamine thiazole biosynthesis enzyme (TIGR00292; HMM-score: 15.3)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Chlorophyll and bacteriochlorphyll geranylgeranyl reductase family (TIGR02032; EC 1.3.1.-; HMM-score: 14.8)
    Metabolism Energy metabolism Amino acids and amines sarcosine oxidase, monomeric form (TIGR01377; HMM-score: 13.8)
    glutamate synthase, NADH/NADPH, small subunit (TIGR01317; EC 1.4.1.-; HMM-score: 13.6)
    oxidoreductase/SelD-related fusion protein (TIGR04369; HMM-score: 12.2)
    mycofactocin system FadH/OYE family oxidoreductase 1 (TIGR03996; EC 1.-.-.-; HMM-score: 11.7)
    lycopene cyclase family protein (TIGR01790; HMM-score: 10.8)
    ubiquinone biosynthesis monooxygenase COQ6 (TIGR01989; EC 1.14.13.-; HMM-score: 10.8)
  • TheSEED: see HMPREF0837_11799
  • PFAM:
    NADP_Rossmann (CL0063) Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase (PF07992; HMM-score: 108.2)
    Pyr_redox_3; Pyridine nucleotide-disulphide oxidoreductase (PF13738; HMM-score: 90)
    and 12 more
    Pyr_redox; Pyridine nucleotide-disulphide oxidoreductase (PF00070; HMM-score: 52.6)
    HI0933_like; HI0933-like protein (PF03486; HMM-score: 39.3)
    DAO; FAD dependent oxidoreductase (PF01266; HMM-score: 28.3)
    Lys_Orn_oxgnase; L-lysine 6-monooxygenase/L-ornithine 5-monooxygenase (PF13434; HMM-score: 27.2)
    NAD_binding_8; NAD(P)-binding Rossmann-like domain (PF13450; HMM-score: 24.8)
    FAD_oxidored; FAD dependent oxidoreductase (PF12831; HMM-score: 21.9)
    Amino_oxidase; Flavin containing amine oxidoreductase (PF01593; HMM-score: 17.2)
    Thi4; Thi4 family (PF01946; HMM-score: 15.6)
    FAD_binding_2; FAD binding domain (PF00890; HMM-score: 14.6)
    NAD_binding_9; FAD-NAD(P)-binding (PF13454; HMM-score: 13.9)
    AlaDh_PNT_C; Alanine dehydrogenase/PNT, C-terminal domain (PF01262; HMM-score: 13.7)
    NAD_binding_7; Putative NAD(P)-binding (PF13241; HMM-score: 12.3)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helix: 1
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.92
    • Cytoplasmic Membrane Score: 0.0752
    • Cell wall & surface Score: 0.0002
    • Extracellular Score: 0.0046
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.051649
    • TAT(Tat/SPI): 0.003037
    • LIPO(Sec/SPII): 0.0026
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000081004 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MSQLYDITIVGGGPVGLFAAFYAHLRQAKVQIIDSLPQLGGQPAILYPEKEILDVPGFPNLTGEELTNRLIEQLNGFDTPIHLNETVLEIDKQEEEFAITTSKGSHLTKTVIIAMGGGAFKPRPLELEGVEGYENIHYHVSNIQQYAGKKVTILGGGDSAVDWALAFEKIAPTTLVHRRDNFRALEHSVQALQESSVTIKTPFAPSQLLGNGKTLDKLEITKVKSDETETIDLDHLFVNYGFKSSVGNLKNWGLNLNRHKIIVNSKQESSQAGIYAIGDCCYYDGKIDLIATGLGEAPTAVNNAINYIDPEQKVQPKHSTSL

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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