PangenomeTIGR4

serotype 4

D39

serotype 2

D39V

serotype 2

Hungary19A-6

serotype 19A

EF3030

serotype 19F

670-6B

serotype 6B

6A-10

serotype 6A

70585

serotype 5

A026

serotype 19F

A66

serotype 3

AP200

serotype 11A

ASP0581

serotype 12F

ATCC 49619

serotype 19F

ATCC 700669

serotype 23F

BVJ1JL

serotype 1

CGSP14

serotype 14

G54

serotype 19F

HU-OH

serotype 3

Hu15

serotype 19A

Hu17

serotype 19A

INV104

serotype 1

INV200

serotype 14

JJA

serotype 14

MDRSPN001

serotype 19F

NCTC7466

serotype 2

NU83127

serotype 4

OXC141

serotype 3

P1031

serotype 1

R6

serotype 2

SP49

serotype 19A

SPN032672

serotype 1

SPN034156

serotype 3

SPN034183

serotype 3

SPN994038

serotype 3

SPN994039

serotype 3

SPNA45

serotype 3

ST556

serotype 19F

TCH8431/19A

serotype 19A

Taiwan19F-14

serotype 19F

Xen35

serotype 4

gamPNI0373

serotype 1

NCBI: 02-AUG-2013

⊟Summary

• organism: Streptococcus pneumoniae gamPNI0373
• locus tag: HMPREF1038_00509 [new locus tag: HMPREF1038_RS02505 ]
• pan locus tag^?: PNEUPAN001353000
• symbol: HMPREF1038_00509
• pan gene symbol^?: xylR
• synonym:
• product: putative regulator

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: HMPREF1038_00509 [new locus tag: HMPREF1038_RS02505 ]
• symbol: HMPREF1038_00509
• product: putative regulator
• replicon: chromosome
• strand: -
• coordinates: 450559..451782
• length: 1224
• essential: unknown

⊟Accession numbers

• Location: CP001845 (450559..451782) NCBI
• BioCyc: see HMPREF1038_RS02505
• MicrobesOnline:
• PneumoBrowse for strain D39V: SPV_0423 PneumoBrowse

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

• 1
  61
  121
  181
  241
  301
  361
  421
  481
  541
  601
  661
  721
  781
  841
  901
  961
  1021
  1081
  1141
  1201
  
  ATGATTACAAAACAATCAGCCTTTTTACAAAATAGAGCCACTATACTGGAGTTTCTATAT
  CGAAATCCAGCAACATCCCGTACAGATATTGTTAATGAAACAGGACTTACTCCAGCAACA
  ACGACTAACATCATAAAAGAGCTAAGCGAACAGTCCCTCATATACGAAACTGGTGATGAA
  TTTAGCGAGTTTTCCGGATCTGGAAGACGTAGAAAAACTATTTCTATCACAGATAATATT
  CCGTATGTTGTTGGAGGTATTGAAATAAACGTCCTAGGTATCTTTCTCAGTCTATGTGAC
  TTACAAGGGAAAACTCTTTTCGAGACAGAAATTTTGAATGAAGATTATCCTATTTCAGAA
  ATCAATTCCACCATTACCAATATGATAAAAACAGCTATAGAGTACGTCCCTTTGGAAACA
  AAATTACTTGGATTTGGCTTATCAATACCTGGACATTATAACAAAGACTCCGGAAGTATC
  ATTACAAACAACCCCATATGGGAATCTTTTAATTTATTAAATGTAATTAAAAGATTCAAT
  TTTCCTTTTATTGTAAAAAATAATATCGATTGTATGGCTATAGGACAATACCTTTTTAAT
  CCACACAATACCCCCGATAACTTTATTTTCCTACACGCTGGATTAGGTATTTACACTTCC
  TTTTTCACAAAAGAAAAAATAGGAGCCTCTAAAAATCCTTATATCGGAGAAATTGGACAC
  ACCATTGTCGAATTGAATGGGCAATATTGTGAATGCGGAAAAAAAGGTTGTTTACAAACA
  TATATTTCGGATGCTTGGTTAATCAAACACGCCCAATTATTATTTAAAAATTCCCAACTA
  ACTGTACTAAAAAGCCTTGTAAAGACTGAAAAAGACATTCATTTAGACACCCTTTTAACG
  GCTTATAATTTAGGCGACTCCGCTTTACGTCAACAAATTGATAAAGGAGTCAATTTATTA
  GCCACTTCTATTGCAAATCTTCTCCTCATCAATCCTGCTGATAAAATCTATATCAACAGT
  CAATTGCTTAATTATCAACCTTTCACTCATGAAGTCAGGGATAAAATCCAAGACCAGCTC
  CACTTCGTTCCCTTTACTCGTAATATAGAAATTGAAATTTTACCTTACAACAAACATCGT
  GGAAGTATAGGAGCTTGTGCATTAGCTATCGTTGCTTTTTTCATAGAGCATAGCAATGTA
  TTACAAGATATTATTTCACCTTAA
  60
  120
  180
  240
  300
  360
  420
  480
  540
  600
  660
  720
  780
  840
  900
  960
  1020
  1080
  1140
  1200
  1224
  

⊟Protein

⊟General

• locus tag: HMPREF1038_00509 [new locus tag: HMPREF1038_RS02505 ]
• symbol: HMPREF1038_00509
• description: putative regulator
• length: 407
• theoretical pI: 6.18301
• theoretical MW: 45735.1
• GRAVY: -0.0272727

⊟Function

• TIGRFAM:
  Unknown function General ROK family protein (putative glucokinase) (TIGR00744; HMM-score: 64.8)
  and 1 more
  Signal transduction Regulatory functions DNA interactions CRISPR locus-related DNA-binding protein (TIGR01884; HMM-score: 11.6)
• TheSEED  :
  • Xylose repressor protein
• PFAM:
  Actin_ATPase (CL0108) ROK; ROK family (PF00480; HMM-score: 117.1)
  and 6 more
  HTH (CL0123) MarR_2; MarR family (PF12802; HMM-score: 24)
  HTH_24; Winged helix-turn-helix DNA-binding (PF13412; HMM-score: 23.9)
  MarR; MarR family (PF01047; HMM-score: 22)
  HTH_Mga; M protein trans-acting positive regulator (MGA) HTH domain (PF08280; HMM-score: 17.5)
  HTH_IclR; IclR helix-turn-helix domain (PF09339; HMM-score: 15.4)
  HTH_Crp_2; Crp-like helix-turn-helix domain (PF13545; HMM-score: 13.8)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:
• genes regulated by XylR*, TF important in Cellobiose utilization: in TIGR4

⊟Localization

• PSORTb: Cytoplasmic
  • Cytoplasmic Score: 9.64
  • Cytoplasmic Membrane Score: 0.3
  • Cellwall Score: 0.06
  • Extracellular Score: 0.01
  • Internal Helices: 0
• SignalP: no predicted signal peptide
  • SP(Sec/SPI): 0.009832
  • TAT(Tat/SPI): 0.002516
  • LIPO(Sec/SPII): 0.001568
• predicted transmembrane helices (TMHMM): 0

⊟Accession numbers

• GI:
• RefSeq: AFS42582 NCBI
• UniProt:

⊟Protein sequence

• MITKQSAFLQNRATILEFLYRNPATSRTDIVNETGLTPATTTNIIKELSEQSLIYETGDEFSEFSGSGRRRKTISITDNIPYVVGGIEINVLGIFLSLCDLQGKTLFETEILNEDYPISEINSTITNMIKTAIEYVPLETKLLGFGLSIPGHYNKDSGSIITNNPIWESFNLLNVIKRFNFPFIVKNNIDCMAIGQYLFNPHNTPDNFIFLHAGLGIYTSFFTKEKIGASKNPYIGEIGHTIVELNGQYCECGKKGCLQTYISDAWLIKHAQLLFKNSQLTVLKSLVKTEKDIHLDTLLTAYNLGDSALRQQIDKGVNLLATSIANLLLINPADKIYINSQLLNYQPFTHEVRDKIQDQLHFVPFTRNIEIEILPYNKHRGSIGACALAIVAFFIEHSNVLQDIISP

⊟Experimental data

• protein localization:
• interaction partners:

⊟Expression & Regulation

⊟Operon

⊟Regulation

• data available for TIGR4

⊟Expression data

• PneumoExpress for strain D39V: SPV_0423 PneumoExpress

⊟Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊟Other Information

You are kindly invited to share additional interesting facts.

⊟Literature

⊟References

⊟Relevant publications