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SPNA45
serotype 3
ST556
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TCH8431/19A
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serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 02-AUG-2013

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae gamPNI0373
  • locus tag: HMPREF1038_01402 [new locus tag: HMPREF1038_RS06855 ]
  • pan locus tag?: PNEUPAN002691000
  • symbol: nagB
  • pan gene symbol?: nagB
  • synonym:
  • product: glucosamine-6-phosphate deaminase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: HMPREF1038_01402 [new locus tag: HMPREF1038_RS06855 ]
  • symbol: nagB
  • product: glucosamine-6-phosphate deaminase
  • replicon: chromosome
  • strand: -
  • coordinates: 1294984..1295706
  • length: 723
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    ATGGAGGATGAAAAGATGAAAGTTATTAAAGTTGAAAACCAAGTTCAAGGTGGAAAAGTT
    GCTTTTGAGATGTTGAAGGAAAAATTGGCTAATGGAGCTCAAACTCTAGGACTTGCGACA
    GGAAGTAGCCCACTTGAATTTTACAAGGAAATTGTTGAGAGTAACCTTGATTTTTCAAAT
    CTAACCAGTGTCAACCTTGATGAGTATGTGGGCCTTGATGGGGACAATCCACAGTCTTAT
    CGTTACTTCATGCAAGAAAACTTGTTCAACCAAAAACCATTTAAAGAAAGTTTCTTGCCT
    CGTGGTGTTAAGGACAATGCTGAAGCTGAAGTTGAACGCTACAACCAAATTTTGGCTGAC
    CATCCAGTTGACCTCCAAATCTTGGGAATTGGTCGCAATGGGCATATCGGCTTTAATGAG
    CCTGGTACTCCATTTGACAGTCAAACGCATCTAGTAGAACTTGACCAGTCTACTATCGAA
    GCCAATGCACGCTTCTTTGCCAAGATTGAAGACGTCCCAACCCAAGCTATTTCAATGGGG
    ATTAAAAACATTTTGGATGCCAAGTCTATTATTCTTTTTGCTTACGGTGAGTCGAAAGCA
    GAAGCCATTGCCGGAACAGTATCTGGCCCAGTGACTGAGAACCTACCTGCAAGTAGCCTC
    CAAAATCACCCTGATGTAACCATCATCGCAGATGCTGAAGCGCTTAGCTTACTCGAAAAA
    TAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    723

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: HMPREF1038_01402 [new locus tag: HMPREF1038_RS06855 ]
  • symbol: NagB
  • description: glucosamine-6-phosphate deaminase
  • length: 240
  • theoretical pI: 4.30128
  • theoretical MW: 26379.4
  • GRAVY: -0.299167

⊟Function[edit | edit source]

  • reaction:
    EC 3.5.99.6?  ExPASy
    Glucosamine-6-phosphate deaminase Alpha-D-glucosamine 6-phosphate + H2O = D-fructose 6-phosphate + NH3
  • TIGRFAM:
    Metabolism Central intermediary metabolism Amino sugars glucosamine-6-phosphate deaminase (TIGR00502; EC 3.5.99.6; HMM-score: 230)
    and 1 more
    Metabolism Energy metabolism Pentose phosphate pathway 6-phosphogluconolactonase (TIGR01198; EC 3.1.1.31; HMM-score: 59.8)
  • TheSEED  :
    • Glucosamine-6-phosphate deaminase (EC 3.5.99.6)
    Carbohydrates Aminosugars Chitin and N-acetylglucosamine utilization  Glucosamine-6-phosphate deaminase (EC 3.5.99.6)
    and 2 more
    Cell Wall and Capsule Capsular and extracellular polysacchrides Sialic Acid Metabolism  Glucosamine-6-phosphate deaminase (EC 3.5.99.6)
    Cell Wall and Capsule Cell Wall and Capsule - no subcategory UDP-N-acetylmuramate from Fructose-6-phosphate Biosynthesis  Glucosamine-6-phosphate deaminase (EC 3.5.99.6)
  • PFAM:
    ISOCOT_Fold (CL0246) Glucosamine_iso; Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase (PF01182; HMM-score: 55.3)
    and 1 more
    Sugar-bind; Putative sugar-binding domain (PF04198; HMM-score: 20.4)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9988
    • Cytoplasmic Membrane Score: 0.0001
    • Cell wall & surface Score: 0.0001
    • Extracellular Score: 0.0011
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.01326
    • TAT(Tat/SPI): 0.007025
    • LIPO(Sec/SPII): 0.001906
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: AFS43434 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MEDEKMKVIKVENQVQGGKVAFEMLKEKLANGAQTLGLATGSSPLEFYKEIVESNLDFSNLTSVNLDEYVGLDGDNPQSYRYFMQENLFNQKPFKESFLPRGVKDNAEAEVERYNQILADHPVDLQILGIGRNGHIGFNEPGTPFDSQTHLVELDQSTIEANARFFAKIEDVPTQAISMGIKNILDAKSIILFAYGESKAEAIAGTVSGPVTENLPASSLQNHPDVTIIADAEALSLLEK

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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