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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 15-OCT-2021

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae gamPNI0373
  • locus tag: HMPREF1038_RS04100 [old locus tag: HMPREF1038_00832 ]
  • pan locus tag?: PNEUPAN001789000
  • symbol: HMPREF1038_RS04100
  • pan gene symbol?: clpE
  • synonym:
  • product: ATP-dependent Clp protease ATP-binding subunit

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: HMPREF1038_RS04100 [old locus tag: HMPREF1038_00832 ]
  • symbol: HMPREF1038_RS04100
  • product: ATP-dependent Clp protease ATP-binding subunit
  • replicon: chromosome
  • strand: -
  • coordinates: 761097..763355
  • length: 2259
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NC_018630 (761097..763355) NCBI
  • BioCyc: HMPREF1038_RS04100 BioCyc
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_0717 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    1741
    1801
    1861
    1921
    1981
    2041
    2101
    2161
    2221
    ATGCTTTGTCAAAACTGTAAAATTAACGACTCAACAATTCATCTTTACACCAATCTCAAT
    GGAAAACAAAAACAAATTGACCTCTGTCAAAACTGCTATAAGATTATCAAAACAGATCCT
    AACAATAGCCTCTTCAAAGGTATGACGGATCTGAACAATCGTGACTTCGATCCCTTTGGT
    GATTTCTTCAATGATCTAAACAATTTCAGACCTTCTAGCAATACTCCTCCTATTCCCCCA
    ACCCAATCAGGTGGAGGTTACGGTGGAAACGGCGGTTATGGTTCCCAAAATCGTGGATCT
    GCTCAAACTCCGCCACCTAGCCAAGAAAAAGGCCTGCTGGAAGAATTTGGTATTAATGTA
    ACTGAAATTGCCCGTCGTGGAGACATTGACCCCGTTATTGGGCGCGACGATGAGATTATC
    CGTGTCATCGAGATTCTCAATCGTAGAACGAAGAATAATCCTGTCCTTATCGGTGAACCT
    GGTGTCGGAAAAACGGCCGTTGTCGAAGGTCTAGCTCAGAAAATTGTCGATGGCGATGTG
    CCACATAAACTCCAAGGTAAACAAGTCATCCGTCTGGATGTGGTTAGCTTAGTTCAAGGA
    ACGGGGATTCGAGGACAATTTGAAGAACGCATGCAAAAACTCATGGAAGAAATTCGCAAA
    CGTGAAGACATCATCCTCTTTATCGATGAAATCCATGAAATTGTTGGTGCTGGTTCTGCG
    AGTGATGGTAATATGGACGCAGGAAATATCCTCAAGCCAGCCCTTGCTCGTGGAGAACTG
    CAACTAGTCGGTGCTACTACCCTCAATGAATACCGTATCATTGAAAAGGATGCTGCCCTC
    GAGCGTCGTATGCAGCCTGTTAAAGTCGATGAACCAACGGTGGATGAAACAATCACTATT
    CTCAAAGGGATTCAAAAGAAATACGAAGATTACCACCACGTTCAATATACCGATGCTGCG
    ATTGAAGCAGCTGCAACTCTTTCCAATCGCTACATCCAAGATCGCTTCTTGCCTGACAAG
    GCCATTGACCTCCTAGATGAAGCTGGTTCTAAGATGAACTTGACCTTGAATTTTGTGGAT
    CCTAAAGTAATTGATCAGCGCTTGATTGAGGCTGAAAATCTCAAGTCTCAAGCTACACGA
    GAAGAAGATTTTGAGAAGGCGGCCTACTTCCGCGACCAGATTGCCAAGTATAAGGAAATG
    CAAAAGAAAAAGATCACAGACCAGGATACTCCTATCATCAGCGAGAAAACTATTGAGCAC
    ATTATCGAGCAGAAAACCAATATCCCTGTTGGTGATTTGAAAGAGAAAGAACAATCTCAA
    CTCATCCATCTAGCCGAAGATCTCAAGTCTCATGTTATTGGCCAAGATGATGCAGTCGAT
    AAGATTGCCAAGGCTATTCGCCGTAATCGTGTCGGACTTGGTACCCCTAACCGCCCAATC
    GGAAGCTTCCTCTTCGTTGGGCCAACTGGTGTCGGTAAGACAGAACTTTCCAAACAACTG
    GCTATCGAACTTTTTGGTTCTGCTGATAGTATGATTCGCTTTGATATGAGTGAATACATG
    GAAAAACATAGTGTGGCTAAGTTGGTCGGCGCTCCTCCAGGTTATGTTGGCTATGATGAG
    GCTGGTCAATTAACTGAAAAAGTTCGCCACAATCCATATTCTCTCATCCTTCTCGATGAA
    GTGGAAAAAGCTCACCCAGATGTTATGCACATGTTTCTTCAAGTCTTGGACGATGGTCGT
    TTGACAGACGGGCAAGGACGCACCGTTAGCTTCAAGGATGCCATCATTATCATGACCTCA
    AATGCAGGTACAGGAAAGACCGAAGCTAGCGTTGGATTTGGTGCTGCTAGAGAAGGACGT
    ACCAATTCTGTCCTCGGTGAACTCGGTAACTTCTTTAGCCCAGAGTTTATGAACCGTTTT
    GATGGCATTATCGAATTTAAGGCTCTCAGCAAGGATAACCTCCTTCAGATTGTCGAGCTC
    ATGCTAGCAGATGTTAACAAGCGCCTCTCTAGCAACAACATTCGTTTGGATGTAACTGAC
    AAGGTCAAGGAAAAGTTGGTTGACCTAGGTTATGATCCAAAAATGGGAGCACGCCCACTT
    CGTCGGACTATTCAAGACTATATTGAGGACACAATCACTGACTACTACCTTGAAAATCCA
    AGCGAAAAAGATCTCAAAGCAGTTATGACTAGCAAGGGAAACATTCAGATTAAATCTGCC
    AAAAAAGCTGAAGTTAAAAGTTCTGAAAAAGAAAAATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1680
    1740
    1800
    1860
    1920
    1980
    2040
    2100
    2160
    2220
    2259

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: HMPREF1038_RS04100 [old locus tag: HMPREF1038_00832 ]
  • symbol: HMPREF1038_RS04100
  • description: ATP-dependent Clp protease ATP-binding subunit
  • length: 752
  • theoretical pI: 5.37185
  • theoretical MW: 83839.7
  • GRAVY: -0.497606

⊟Function[edit | edit source]

  • TIGRFAM:
    Genetic information processing Protein fate Protein folding and stabilization ATP-dependent chaperone protein ClpB (TIGR03346; HMM-score: 813.6)
    Genetic information processing Protein fate Degradation of proteins, peptides, and glycopeptides ATP-dependent Clp protease ATP-binding subunit ClpA (TIGR02639; HMM-score: 729.9)
    Cellular processes Cellular processes Pathogenesis type VI secretion ATPase, ClpV1 family (TIGR03345; HMM-score: 654.8)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking type VI secretion ATPase, ClpV1 family (TIGR03345; HMM-score: 654.8)
    and 13 more
    Genetic information processing Protein fate Degradation of proteins, peptides, and glycopeptides ATP-dependent Clp protease, ATP-binding subunit ClpX (TIGR00382; HMM-score: 41.6)
    Genetic information processing Protein fate Protein folding and stabilization ATP-dependent Clp protease, ATP-binding subunit ClpX (TIGR00382; HMM-score: 41.6)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair orc1/cdc6 family replication initiation protein (TIGR02928; HMM-score: 27.8)
    Cellular processes Cellular processes Chemotaxis and motility flagellar biosynthesis protein FlhF (TIGR03499; HMM-score: 26.5)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking type VII secretion AAA-ATPase EccA (TIGR03922; HMM-score: 26.4)
    Genetic information processing Protein fate Degradation of proteins, peptides, and glycopeptides putative ATP-dependent protease (TIGR00764; HMM-score: 26.1)
    Cellular processes Cellular processes Sporulation and germination stage V sporulation protein K (TIGR02881; HMM-score: 22)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair DNA polymerase III, subunit gamma and tau (TIGR02397; EC 2.7.7.7; HMM-score: 21.9)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair Holliday junction DNA helicase RuvB (TIGR00635; EC 3.6.4.12; HMM-score: 19)
    CbbX protein (TIGR02880; HMM-score: 18)
    Cellular processes Cellular processes Sporulation and germination stage III sporulation protein AA (TIGR02858; HMM-score: 15.5)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair DNA polymerase III, delta' subunit (TIGR00678; EC 2.7.7.7; HMM-score: 14.4)
    Cellular processes Cellular processes Other gas vesicle protein GvpN (TIGR02640; HMM-score: 12.8)
  • TheSEED: see HMPREF1038_00832
  • PFAM:
    P-loop_NTPase (CL0023) AAA_2; AAA domain (Cdc48 subfamily) (PF07724; HMM-score: 180.3)
    and 43 more
    AAA_lid (CL0671) AAA_lid_9; AAA lid domain (PF17871; HMM-score: 101.9)
    P-loop_NTPase (CL0023) AAA; ATPase family associated with various cellular activities (AAA) (PF00004; HMM-score: 84.2)
    AAA_lid (CL0671) ClpB_D2-small; C-terminal, D2-small domain, of ClpB protein (PF10431; HMM-score: 83.2)
    P-loop_NTPase (CL0023) AAA_5; AAA domain (dynein-related subfamily) (PF07728; HMM-score: 60.3)
    AAA_16; AAA ATPase domain (PF13191; HMM-score: 43.2)
    Sigma54_activat; Sigma-54 interaction domain (PF00158; HMM-score: 35.6)
    AAA_22; AAA domain (PF13401; HMM-score: 34.4)
    AAA_14; AAA domain (PF13173; HMM-score: 34)
    AAA_lid (CL0671) UVR; UvrB/uvrC motif (PF02151; HMM-score: 32.2)
    P-loop_NTPase (CL0023) TniB; Bacterial TniB protein (PF05621; HMM-score: 29.2)
    Zeta_toxin; Zeta toxin (PF06414; HMM-score: 26.8)
    IstB_IS21; IstB-like ATP binding protein (PF01695; HMM-score: 24.1)
    AAA_7; P-loop containing dynein motor region (PF12775; HMM-score: 24.1)
    bpMoxR; MoxR domain in the MoxR-vWA-beta-propeller ternary systems (PF20030; HMM-score: 23.7)
    AAA_18; AAA domain (PF13238; HMM-score: 22.8)
    RNA_helicase; RNA helicase (PF00910; HMM-score: 22.5)
    AAA_33; AAA domain (PF13671; HMM-score: 22)
    NACHT; NACHT domain (PF05729; HMM-score: 21.7)
    TsaE; Threonylcarbamoyl adenosine biosynthesis protein TsaE (PF02367; HMM-score: 21.2)
    RuvB_N; Holliday junction DNA helicase RuvB P-loop domain (PF05496; HMM-score: 20.4)
    AAA_30; AAA domain (PF13604; HMM-score: 19.4)
    AAA_24; AAA domain (PF13479; HMM-score: 19.2)
    Roc; Ras of Complex, Roc, domain of DAPkinase (PF08477; HMM-score: 18.6)
    ATPase_2; ATPase domain predominantly from Archaea (PF01637; HMM-score: 18.4)
    ResIII; Type III restriction enzyme, res subunit (PF04851; HMM-score: 18.2)
    AAA_3; ATPase family associated with various cellular activities (AAA) (PF07726; HMM-score: 16.8)
    AAA_28; AAA domain (PF13521; HMM-score: 16.8)
    RsgA_GTPase; RsgA GTPase (PF03193; HMM-score: 16.6)
    DUF815; Protein of unknown function (DUF815) (PF05673; HMM-score: 16.1)
    AAA_25; AAA domain (PF13481; HMM-score: 15.6)
    Torsin; Torsin (PF06309; HMM-score: 14.5)
    Mg_chelatase; Magnesium chelatase, subunit ChlI (PF01078; HMM-score: 14.1)
    VirE; Virulence-associated protein E (PF05272; HMM-score: 13.2)
    AAA_29; P-loop containing region of AAA domain (PF13555; HMM-score: 12.9)
    no clan defined CRS1_YhbY; CRS1 / YhbY (CRM) domain (PF01985; HMM-score: 12.8)
    BOFC_N; Bypass of Forespore C, N terminal (PF08977; HMM-score: 12.6)
    SNAPC3; snRNA-activating protein complex (SNAPc), subunit 3 (PF12251; HMM-score: 12.5)
    P-loop_NTPase (CL0023) ABC_tran; ABC transporter (PF00005; HMM-score: 12.2)
    PhoH; PhoH-like protein (PF02562; HMM-score: 11.9)
    NTPase_1; NTPase (PF03266; HMM-score: 11.9)
    AAA_19; AAA domain (PF13245; HMM-score: 11.9)
    AAA_17; AAA domain (PF13207; HMM-score: 11.6)
    no clan defined Rav1p_C; RAVE protein 1 C terminal (PF12234; HMM-score: 11.2)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.94
    • Cytoplasmic Membrane Score: 2.06
    • Cellwall Score: 0
    • Extracellular Score: 0
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.069979
    • TAT(Tat/SPI): 0.000311
    • LIPO(Sec/SPII): 0.007895
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000882517 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MLCQNCKINDSTIHLYTNLNGKQKQIDLCQNCYKIIKTDPNNSLFKGMTDLNNRDFDPFGDFFNDLNNFRPSSNTPPIPPTQSGGGYGGNGGYGSQNRGSAQTPPPSQEKGLLEEFGINVTEIARRGDIDPVIGRDDEIIRVIEILNRRTKNNPVLIGEPGVGKTAVVEGLAQKIVDGDVPHKLQGKQVIRLDVVSLVQGTGIRGQFEERMQKLMEEIRKREDIILFIDEIHEIVGAGSASDGNMDAGNILKPALARGELQLVGATTLNEYRIIEKDAALERRMQPVKVDEPTVDETITILKGIQKKYEDYHHVQYTDAAIEAAATLSNRYIQDRFLPDKAIDLLDEAGSKMNLTLNFVDPKVIDQRLIEAENLKSQATREEDFEKAAYFRDQIAKYKEMQKKKITDQDTPIISEKTIEHIIEQKTNIPVGDLKEKEQSQLIHLAEDLKSHVIGQDDAVDKIAKAIRRNRVGLGTPNRPIGSFLFVGPTGVGKTELSKQLAIELFGSADSMIRFDMSEYMEKHSVAKLVGAPPGYVGYDEAGQLTEKVRHNPYSLILLDEVEKAHPDVMHMFLQVLDDGRLTDGQGRTVSFKDAIIIMTSNAGTGKTEASVGFGAAREGRTNSVLGELGNFFSPEFMNRFDGIIEFKALSKDNLLQIVELMLADVNKRLSSNNIRLDVTDKVKEKLVDLGYDPKMGARPLRRTIQDYIEDTITDYYLENPSEKDLKAVMTSKGNIQIKSAKKAEVKSSEKEK

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

Wenjuan Yan, Yingying Cai, Qun Zhang, Yusi Liu, Wenchun Xu, Yibing Yin, Yujuan He, Hong Wang, Xuemei Zhang
Screening and identification of ClpE interaction proteins in Streptococcus pneumoniae by a bacterial two-hybrid system and co-immunoprecipitation.
J Microbiol: 2013, 51(4);453-60
[PubMed:23990296] [WorldCat.org] [DOI] (I p)

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