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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 15-OCT-2021

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae gamPNI0373
  • locus tag: HMPREF1038_RS05960 [old locus tag: HMPREF1038_01211 ]
  • pan locus tag?: PNEUPAN002468000
  • symbol: HMPREF1038_RS05960
  • pan gene symbol?: tylA
  • synonym:
  • product: TlyA family RNA methyltransferase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: HMPREF1038_RS05960 [old locus tag: HMPREF1038_01211 ]
  • symbol: HMPREF1038_RS05960
  • product: TlyA family RNA methyltransferase
  • replicon: chromosome
  • strand: -
  • coordinates: 1121860..1122675
  • length: 816
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

  • Location: NC_018630 (1121860..1122675) NCBI
  • BioCyc: HMPREF1038_RS05960 BioCyc
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_1064 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    ATGGCTAAGGAAAGAGTGGATGTACTAGCTTATAAACAGGGGTTGTTTGAAACGAGAGAG
    CAGGCCAAGCGAGGTGTGATGGCTGGCCTAGTCGTAGCAGTCCTTAATGGAGAACGGTTT
    GACAAGCCAGGAGAGAAAATTCCAGATGACACCGAATTAAAACTCAAGGGGGAGAAACTC
    AAGTATGTCAGCCGTGGTGGTTTGAAACTGGAAAAGGCCTTGCAGGTCTTTGATTTGTCG
    GTGGATGGCGCGACTACGATTGATATCGGGGCCTCTACTGGAGGTTTTACCGATGTCATG
    CTACAGAATAGTGCCAAGTTGGTCTTTGCAGTCGATGTTGGTACCAATCAGTTGGCTTGG
    AAATTACGCCAAGACCCACGAGTTGTCAGCATGGAGCAGTTCAATTTCCGCTATGCTGAA
    AAGACTGATTTCGAGCAGGAGCCGAGCTTTGCCAGTATTGATGTGAGTTTCATTTCCCTT
    AGTCTGATTTTGCCAGCCTTGCACCGTGTCTTGGCTGATCAAGGTCAGGTGGTAGCACTT
    GTCAAACCTCAGTTTGAGGCAGGACGTGAGCAGATTGGGAAAAATGGAATTATTCGAGAT
    GCTAAGGTTCATCAGAATGTCCTTGAATCTGTAACAGCTATGGCAGTAGAGGTAGGTTTT
    TCAGTCCTTGGCTTGGACTTTTCTCCCATCCAAGGTGGACATGGAAATATTGAATTTTTA
    GCGTATTTGAAAAAAGAAAAGTCAGCAAGCAATCAGATTCTTGCTGAGATTAAAGAAGCA
    GTAGAGAGGGCGCATAGTCAATTTAAAAATGAATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    816

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: HMPREF1038_RS05960 [old locus tag: HMPREF1038_01211 ]
  • symbol: HMPREF1038_RS05960
  • description: TlyA family RNA methyltransferase
  • length: 271
  • theoretical pI: 6.1658
  • theoretical MW: 29824.9
  • GRAVY: -0.161624

⊟Function[edit | edit source]

  • TIGRFAM:
    Unknown function General TlyA family rRNA methyltransferase/putative hemolysin (TIGR00478; HMM-score: 251.6)
    and 2 more
    Genetic information processing Protein synthesis tRNA and rRNA base modification ribosomal RNA large subunit methyltransferase J (TIGR00438; EC 2.1.1.166; HMM-score: 26.8)
    Genetic information processing Protein synthesis Ribosomal proteins: synthesis and modification ribosomal protein uS4 (TIGR01017; HMM-score: 12.7)
  • TheSEED: see HMPREF1038_01211
  • PFAM:
    NADP_Rossmann (CL0063) FtsJ; FtsJ-like methyltransferase (PF01728; HMM-score: 67.1)
    and 2 more
    S4 (CL0492) S4; S4 domain (PF01479; HMM-score: 20.6)
    NADP_Rossmann (CL0063) Methyltransf_12; Methyltransferase domain (PF08242; HMM-score: 13.7)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.007184
    • TAT(Tat/SPI): 0.001009
    • LIPO(Sec/SPII): 0.005323
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_001041079 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MAKERVDVLAYKQGLFETREQAKRGVMAGLVVAVLNGERFDKPGEKIPDDTELKLKGEKLKYVSRGGLKLEKALQVFDLSVDGATTIDIGASTGGFTDVMLQNSAKLVFAVDVGTNQLAWKLRQDPRVVSMEQFNFRYAEKTDFEQEPSFASIDVSFISLSLILPALHRVLADQGQVVALVKPQFEAGREQIGKNGIIRDAKVHQNVLESVTAMAVEVGFSVLGLDFSPIQGGHGNIEFLAYLKKEKSASNQILAEIKEAVERAHSQFKNE

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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