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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 04-FEB-2016

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae INV104
  • locus tag: INV104_00010 [new locus tag: INV104_RS00005 ]
  • pan locus tag?: PNEUPAN000168000
  • symbol: dnaA
  • pan gene symbol?: dnaA
  • synonym:
  • product: chromosomal replication initiator protein

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: INV104_00010 [new locus tag: INV104_RS00005 ]
  • symbol: dnaA
  • product: chromosomal replication initiator protein
  • replicon: chromosome
  • strand: +
  • coordinates: 186..1547
  • length: 1362
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    TTGAAAGAAAAACAATTTTGGAATCGTATATTAGAATTTGCACAAGAAAGACTGACTCGA
    TCCATGTATGATTTCTATGCTATTCAAGCTGAACTTATCAAGGTAGAGGAAAATGTTGCC
    ACTATATTTCTACCTCGCTCTGAAATGGAAATGGTCTGGGAAAAACAACTAAAAGATATT
    ATTGTAGTAGCTGGTTTTGAAATTTATGACGCTGAAATAACTCCCCACTATATTTTCACC
    AAACCTCAAGATACGACTAGCTCACAAGTTGAAGAAGCTACAAATTTAACTCTTTATGAC
    TATAGTCCAAAGTTAGTATCTATTCCTTATTCAGATACGGGATTAAAAGAAAAGTATACC
    TTTGATAACTTTATTCAAGGGGATGGAAATGTTTGGGCTGTATCAGCCGCTTTAGCTGTC
    TCTGAAGATTTGGCTCTGACCTATAACCCTCTTTTTATCTATGGAGGACCAGGCCTTGGT
    AAGACTCACTTATTAAACGCTATTGGAAATGAAATTCTAAAAAATATTCCTAATGCGCGT
    GTTAAATATATCCCTGCCGAAAGCTTTATTAATGACTTTCTTGATCACCTAAGACTTGGG
    GAAATGGAAAAGTTTAAAAAGACCTATCGTAGTCTTGATCTTTTGTTAATCGATGATATC
    CAGTCACTCAGCGGAAAAAAAGTCGCAACTCAGGAAGAATTTTTCAATACCTTTAACGCC
    CTTCATGACAAGCAAAAACAGATTGTCCTAACGAGTGATCGTAGTCCAAAACATCTAGAA
    GGGCTCGAGGAGAGGCTTGTCACGCGTTTTAGTTGGGGATTGACACAAACTATCACACCC
    CCTGACTTTGAAACACGTATTGCCATTTTACAAAGTAAAACGGAACATTTAGGCTACAAT
    TTCCAAAGTGATACTCTAGAATACCTAGCTGGGCAATTTGATTCAAATGTTCGAGATCTT
    GAGGGAGCCATCAACGACATCACTTTAATTGCCAGAGTAAAAAAAATCAAGGATATCACT
    ATTGATATTGCTGCAGAAGCCATTAGAGCCCGCAAACAAGATGTTAGCCAAATGCTCGTC
    ATCCCAATTGATAAAATCCAAACTGAAGTTGGTAACTTTTATGGTGTTAGTATCAAAGAA
    ATGAAGGGAAGTAGACGCCTTCAAAATATTGTTTTGGCCCGTCAAGTATCCATGTATTTA
    TCTAGAGAACTAACAGATAATAGTCTTCCAAAAATTGGGAAGGAATTTGGGGGAAAAGAT
    CATACCACAGTCATTCATGCTCATGCCAAAATAAAATCTTTGATTGATCAAGACGATAAT
    TTACGTTTAGAAATTGAATCAATCAAAAAGAAAATCAAATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1362

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: INV104_00010 [new locus tag: INV104_RS00005 ]
  • symbol: DnaA
  • description: chromosomal replication initiator protein
  • length: 453
  • theoretical pI: 5.90714
  • theoretical MW: 51797.9
  • GRAVY: -0.314128

⊟Function[edit | edit source]

  • TIGRFAM:
    Genetic information processing DNA metabolism DNA replication, recombination, and repair chromosomal replication initiator protein DnaA (TIGR00362; HMM-score: 512.5)
    and 5 more
    Genetic information processing DNA metabolism DNA replication, recombination, and repair DnaA regulatory inactivator Hda (TIGR03420; HMM-score: 100.2)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair Holliday junction DNA helicase RuvB (TIGR00635; EC 3.6.4.12; HMM-score: 17.1)
    Cellular processes Cellular processes Conjugation P-type conjugative transfer ATPase TrbB (TIGR02782; HMM-score: 16.8)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair DNA polymerase III, delta subunit (TIGR01128; EC 2.7.7.7; HMM-score: 15.2)
    AAA family ATPase, CDC48 subfamily (TIGR01243; HMM-score: 14)
  • TheSEED  :
    • Chromosomal replication initiator protein DnaA
    DNA Metabolism DNA replication DNA-replication  Chromosomal replication initiator protein DnaA
  • PFAM:
    P-loop_NTPase (CL0023) Bac_DnaA; Bacterial dnaA protein (PF00308; HMM-score: 277.2)
    and 13 more
    HTH (CL0123) Bac_DnaA_C; Bacterial dnaA protein helix-turn-helix (PF08299; HMM-score: 99.8)
    P-loop_NTPase (CL0023) IstB_IS21; IstB-like ATP binding protein (PF01695; HMM-score: 30.4)
    AAA; ATPase family associated with various cellular activities (AAA) (PF00004; HMM-score: 29.5)
    ATPase_2; ATPase domain predominantly from Archaea (PF01637; HMM-score: 27.4)
    AAA_14; AAA domain (PF13173; HMM-score: 23.7)
    AAA_22; AAA domain (PF13401; HMM-score: 21.2)
    RNA_helicase; RNA helicase (PF00910; HMM-score: 19)
    RuvB_N; Holliday junction DNA helicase RuvB P-loop domain (PF05496; HMM-score: 17.6)
    AAA_19; AAA domain (PF13245; HMM-score: 17.2)
    AAA_16; AAA ATPase domain (PF13191; HMM-score: 16)
    AAA_24; AAA domain (PF13479; HMM-score: 14.9)
    DUF2075; Schlafen group 3, DNA/RNA helicase domain (PF09848; HMM-score: 13.3)
    NACHT; NACHT domain (PF05729; HMM-score: 12.3)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9206
    • Cytoplasmic Membrane Score: 0.0277
    • Cell wall & surface Score: 0.0036
    • Extracellular Score: 0.0482
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.001044
    • TAT(Tat/SPI): 0.000109
    • LIPO(Sec/SPII): 0.000188
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: CBW35685 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MKEKQFWNRILEFAQERLTRSMYDFYAIQAELIKVEENVATIFLPRSEMEMVWEKQLKDIIVVAGFEIYDAEITPHYIFTKPQDTTSSQVEEATNLTLYDYSPKLVSIPYSDTGLKEKYTFDNFIQGDGNVWAVSAALAVSEDLALTYNPLFIYGGPGLGKTHLLNAIGNEILKNIPNARVKYIPAESFINDFLDHLRLGEMEKFKKTYRSLDLLLIDDIQSLSGKKVATQEEFFNTFNALHDKQKQIVLTSDRSPKHLEGLEERLVTRFSWGLTQTITPPDFETRIAILQSKTEHLGYNFQSDTLEYLAGQFDSNVRDLEGAINDITLIARVKKIKDITIDIAAEAIRARKQDVSQMLVIPIDKIQTEVGNFYGVSIKEMKGSRRLQNIVLARQVSMYLSRELTDNSLPKIGKEFGGKDHTTVIHAHAKIKSLIDQDDNLRLEIESIKKKIK

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

Anne-Marie Gasc, Philippe Giammarinaro, Stefan Richter, Michel Sicard
Organization around the dnaA gene of Streptococcus pneumoniae.
Microbiology (Reading): 1998, 144 ( Pt 2);433-439
[PubMed:9493380] [WorldCat.org] [DOI] (P p)

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