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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 04-FEB-2016

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae INV104
  • locus tag: INV104_18920 [new locus tag: INV104_RS11080 ]
  • pan locus tag?: PNEUPAN003837000
  • symbol: cbpA
  • pan gene symbol?: cbpA
  • synonym: pspC
  • product: choline-binding surface protein A

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: INV104_18920 [new locus tag: INV104_RS11080 ]
  • symbol: cbpA
  • product: choline-binding surface protein A
  • replicon: chromosome
  • strand: -
  • coordinates: 2090319..2091875
  • length: 1557
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: FQ312030 (2090319..2091875) NCBI
  • BioCyc: see INV104_RS11080
  • MicrobesOnline:
  • PneumoBrowse for strain D39V:

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    ATGTTTGCATCAAAAAGCGAAAGAAAAGTACATTATTCAATTCGTAAATTTAGTATTGGA
    GTAGCTAGTGTAGTAGTTGCTAGCTTGTTCTTAGGAGGAGTAGTTCATGCAGAAGGGGTT
    AGAAGTGGGGATACCCCCAAGGTTACATCTAGTGGGGATGAAGTCGAGTCGCATCTAAAA
    AAAATATTGAGTGAGATCCAAACACAATTAGATAGAAAACGACATGCCAAAACTGTAGCG
    CTAATTAACAAGTTGCAAGACATTAAGAGAACGTATTCGTATAAATTAAATGTTTTAGAA
    GAGAAGCCGAAAGCTGAGTTGACGTCAAAAACAAAAGAAGAGTTAACCGCAGCTTTTGAG
    CAATTTAAAAAAGATACATTACCAACAGAACCAGGAAAAAAGGTAGCAGAAGCTGAGAAG
    AAGGTTGCAGAAGCTGAGAAAAAAGCCGAGGATCAAAAAGAAGAAGATCGTCGTAACTAC
    CCAACCAATACTTACAAAACGCTTGAACTTGAAATTGCTGAGTTCGATGTGAAAGTTAAA
    GAAGCGGAGCTTGAACTATTAAAAGAGAAAGCTAAGAAACCTTTAAACGAGGGCACAATT
    AAGCAAGCAAAAGAGAAAGTTGAGAGTAAAAAAGCTGAGGCTACAAGGTTAGAAAACATC
    AAGACAGATCGTAAAAAAGCAGAAGAAGAAGCTAAACGAAAAGCAGCAGAAGAAGATAAA
    GTTAAAGAAAAACCAGCTGAACAACCACAACCAGCGCCGGCTCCTCAACCAGAAAAACCA
    GCTCCAAAACCAGAAAAACCAGCTCCAGCTCCAAAACCAGAGAATCCAGCTCCAAAACCA
    GAAAAACCAGCTCCAGCTCCAAAACCAGAGAATCCAGCTGAACAACCAAAAGCAGAAAAA
    CCAGCTGATCAACAAGCTGAAGAAGACTATGCTCGTAGATCAGAAGAAGAATATAATCGC
    TTGACTCAACAGCAACCGCCAAAAACTGAAAAACCAGCACAACCATCTACTCCAAAAACA
    GGCTGGAAACAAGAAAACGGTATGTGGTACTTCTACAATACTGATGGTTCAATGGCGACA
    GGATGGCTCCAAAACAATGGCTCATGGTACTACCTCAACAGCAATGGCGCTATGGCGACA
    GGATGGCTCCAAAACAATGGTTCATGGTACTATCTAAACGCTAATGGTTCAATGGCAACA
    GGATGGCTCCAAAACAATGGCTCATGGTACTACCTAAACGCTAATGGTTCAATGGCGACA
    GGATGGCTCCAATACAATGGTTCATGGTACTACCTAAACGCTAATGGTTCAATGGCGACA
    GGATGGCTCCAATACAATGGTTCATGGTACTACCTAAACGCTAATGGTGATATGGCGACA
    GATTGGGTGAAAGATGGAGATACCTGGTACTATCTTGAAGCATCAGGTGCTATGAAAGCA
    AGCCAATGGTTCAAAGTATCAGATAAATGGTACTATGTCAATGGCTCAGGTGCCCTTGCA
    GTCAACACAACTGTAGATAGCTATAGAGTCAATGCCAATGGTGAATGGGTAAACTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1557

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: INV104_18920 [new locus tag: INV104_RS11080 ]
  • symbol: CbpA
  • description: choline-binding surface protein A
  • length: 518
  • theoretical pI: 8.90799
  • theoretical MW: 58380.8
  • GRAVY: -1.01834

⊟Function[edit | edit source]

  • TIGRFAM:
    glucan-binding repeat (TIGR04035; HMM-score: 53.1)
    gram-positive signal peptide, YSIRK family (TIGR01168; HMM-score: 52.6)
  • TheSEED  :
    • Choline binding protein A
    Stress Response Osmotic stress Choline and Betaine Uptake and Betaine Biosynthesis  Choline binding protein A
  • PFAM:
    Choline_binding (CL0694) Choline_bind_3; Choline-binding repeat (PF19127; HMM-score: 199)
    and 6 more
    Choline_bind_1; Putative cell wall binding repeat (PF01473; HMM-score: 157.5)
    no clan defined RICH; RICH domain (PF05062; HMM-score: 91.9)
    Choline_binding (CL0694) Choline_bind_2; Choline-binding repeat (PF19085; HMM-score: 52)
    no clan defined YSIRK_signal; YSIRK type signal peptide (PF04650; HMM-score: 42.5)
    FliC; Flagellin protein (PF12445; HMM-score: 21.4)
    DUF4224; Domain of unknown function (DUF4224) (PF13986; HMM-score: 13.5)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Extracellular
    • Cytoplasmic Score: 0.01
    • Cytoplasmic Membrane Score: 0.09
    • Cellwall Score: 0.18
    • Extracellular Score: 9.72
    • Internal Helix: 1
  • SignalP: Signal peptide SP(Sec/SPI) length 37 aa
    • SP(Sec/SPI): 0.955481
    • TAT(Tat/SPI): 0.025951
    • LIPO(Sec/SPII): 0.004276
    • Cleavage Site: CS pos: 37-38. VHA-EG. Pr: 0.8850
  • predicted transmembrane helices (TMHMM): 1

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: CBW37573 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MFASKSERKVHYSIRKFSIGVASVVVASLFLGGVVHAEGVRSGDTPKVTSSGDEVESHLKKILSEIQTQLDRKRHAKTVALINKLQDIKRTYSYKLNVLEEKPKAELTSKTKEELTAAFEQFKKDTLPTEPGKKVAEAEKKVAEAEKKAEDQKEEDRRNYPTNTYKTLELEIAEFDVKVKEAELELLKEKAKKPLNEGTIKQAKEKVESKKAEATRLENIKTDRKKAEEEAKRKAAEEDKVKEKPAEQPQPAPAPQPEKPAPKPEKPAPAPKPENPAPKPEKPAPAPKPENPAEQPKAEKPADQQAEEDYARRSEEEYNRLTQQQPPKTEKPAQPSTPKTGWKQENGMWYFYNTDGSMATGWLQNNGSWYYLNSNGAMATGWLQNNGSWYYLNANGSMATGWLQNNGSWYYLNANGSMATGWLQYNGSWYYLNANGSMATGWLQYNGSWYYLNANGDMATDWVKDGDTWYYLEASGAMKASQWFKVSDKWYYVNGSGALAVNTTVDSYRVNANGEWVN

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

  • PneumoExpress for strain D39V:

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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