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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 11-FEB-2025

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae INV104
  • locus tag: INV104_RS04190 [old locus tag: INV104_07150 ]
  • pan locus tag?: PNEUPAN001816000
  • symbol: dnaX
  • pan gene symbol?: dnaX
  • synonym:
  • product: DNA polymerase III subunit gamma/tau

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: INV104_RS04190 [old locus tag: INV104_07150 ]
  • symbol: dnaX
  • product: DNA polymerase III subunit gamma/tau
  • replicon: chromosome
  • strand: +
  • coordinates: 795883..797538
  • length: 1656
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

  • Location: NC_017591 (795883..797538) NCBI
  • BioCyc: INV104_RS04190 BioCyc
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_0760 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    ATGTATCAAGCACTTTATCGAAAATATAGAAGTCAAAACTTCTCCCAGTTAGTTGGTCAA
    GAAGTTGTGGCTAAGACTCTTAAACAAGCGGTGGAGCAAGAGAAAATAAGTCACGCTTAT
    CTTTTTTCTGGTCCTCGTGGAACGGGAAAAACCAGTGTTGCTAAAATCTTTGCCAAGGCT
    ATGAACTGTCCCAATCAAGTGGGTGGCGAACCTTGCAATAACTGCTATATTTGTCAAGCA
    GTGACGGACGGTAGTTTAGAAGATGTCATTGAAATGGATGCAGCTTCTAATAATGGGGTA
    GATGAAATTCGCGAAATTCGTGATAAATCTACCTATGCGCCTAGCCTTGCTCGTTATAAG
    GTTTATATCATAGATGAGGTTCACATGCTGTCTACAGGGGCTTTTAATGCCCTCCTAAAG
    ACGCTGGAAGAACCAACACAGAATGTAGTCTTTATTTTGGCCACTACTGAATTACACAAG
    ATTCCTGCTACTATTCTATCCCGTGTGCAACGTTTTGAGTTTAAATCAATTAAGACACAG
    GATATTAAGGAACATATTCACTATATCTTAGAAAAAGAAAATATCAGTTCTGAACCAGAG
    GCTGTGGAAATCATTGCCAGACGGGCGGAAGGTGGAATGCGGGACGCCTTGTCTATTTTG
    GATCAAGCCCTGAGTTTGACACAGGGAAATGAGCTGACGACTGCTATCTCTGAAGAAATT
    ACTGGCACTATTAGCCTATCAGCCTTGGATGATTATGTGGCGGCCTTGTCTCAACAGGAT
    GTTCCCAAAGCTTTGTCTTGCTTGAATCTTCTTTTTGACAATGGTAAGAGCATGACTCGT
    TTTGTGACCGATCTTTTGCACTATTTAAGAGACTTGTTAATTGTTCAAACAGGGGGAGAA
    AATACTCATCATAGTTCAGTCTTTGTAGAAAATTTGGCACTTCCTCAAAAAAATCTGTTT
    GAAATGATTCGCTTAGCAACAGTGAGTTTAGCAGATATTAAGTCTAGTTTGCAGCCCAAG
    ATTTATGCTGAAATGATGACCGTCCGTTTGGCGGAAATCAAGCCCGAACCAGCTCTATCA
    GGAGCGGTTGAAAATGAAATTGCTACGCTGAGACAGGAAGTTGCCCGTCTCAAACAAGAG
    CTTTCTAATGTAGGTGCGGTTCCTAAACAAGTTGCACCAGCTCCTAGTCGACCAGCTACG
    GGCAAAACAGTCTATCGTGTCGATCGCAATAAAGTGCAATCTATCTTACAAGAGGCCGTC
    GAAAATCCTGATTTAGCACGTCAAAATCTAATTCGTTTGCAGAATGCCTGGGGAGAGGTA
    ATTGAAAGTCTAGGTGGGCCGGACAAGGCTCTGCTAGTTGGTTCTCAACCGGTTGCTGCC
    AATGAACACCATGCTATTCTTGCTTTTGAGTCTAACTTCAATGCTGGTCAAACTATGAAA
    CGAGACAATCTCAATACCATGTTTGGCAATATCCTCAGTCAGGCGGCAGGTTTTTCACCT
    GAGATTTTAGCTATTTCCATGGAGGAATGGAAAGAAGTTCGCGCAGCCTTTTCAGCCAAA
    GCCAAATCTTCTCAAACTGAAAAAGAAGTAGAAGAAAGCCTGATTCCAGAAGGATTTGAA
    TTTTTGGCTGATAAAGTGAAGGTAGAGGAAGACTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1656

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: INV104_RS04190 [old locus tag: INV104_07150 ]
  • symbol: DnaX
  • description: DNA polymerase III subunit gamma/tau
  • length: 551
  • theoretical pI: 5.07009
  • theoretical MW: 60853.9
  • GRAVY: -0.215245

⊟Function[edit | edit source]

  • reaction:
    EC 2.7.7.7?  ExPASy
    DNA-directed DNA polymerase Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)
  • TIGRFAM:
    Genetic information processing DNA metabolism DNA replication, recombination, and repair DNA polymerase III, subunit gamma and tau (TIGR02397; EC 2.7.7.7; HMM-score: 449.5)
    and 15 more
    Genetic information processing DNA metabolism DNA replication, recombination, and repair DNA polymerase III, delta' subunit (TIGR00678; EC 2.7.7.7; HMM-score: 158.1)
    Cellular processes Cellular processes Sporulation and germination ATP-dependent protease LonB (TIGR02902; EC 3.4.21.-; HMM-score: 38.9)
    Genetic information processing Protein fate Degradation of proteins, peptides, and glycopeptides ATP-dependent protease LonB (TIGR02902; EC 3.4.21.-; HMM-score: 38.9)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair Holliday junction DNA helicase RuvB (TIGR00635; EC 3.6.4.12; HMM-score: 38.7)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair DNA polymerase III, delta subunit (TIGR01128; EC 2.7.7.7; HMM-score: 36.6)
    Cellular processes Cellular processes Sporulation and germination ATP-dependent protease, Lon family (TIGR02903; EC 3.4.21.-; HMM-score: 28.1)
    Genetic information processing Protein fate Degradation of proteins, peptides, and glycopeptides ATP-dependent protease, Lon family (TIGR02903; EC 3.4.21.-; HMM-score: 28.1)
    Cellular processes Cellular processes Sporulation and germination stage V sporulation protein K (TIGR02881; HMM-score: 18.5)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking type VII secretion AAA-ATPase EccA (TIGR03922; HMM-score: 17.8)
    Genetic information processing Protein fate Degradation of proteins, peptides, and glycopeptides ATP-dependent Clp protease ATP-binding subunit ClpA (TIGR02639; HMM-score: 15.3)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair orc1/cdc6 family replication initiation protein (TIGR02928; HMM-score: 14.6)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Chlorophyll and bacteriochlorphyll magnesium chelatase ATPase subunit D (TIGR02031; EC 6.6.1.1; HMM-score: 14.2)
    Genetic information processing Protein fate Degradation of proteins, peptides, and glycopeptides endopeptidase La (TIGR00763; EC 3.4.21.53; HMM-score: 13.8)
    Cellular processes Cellular processes Chemotaxis and motility flagellar biosynthesis protein FlhF (TIGR03499; HMM-score: 12.4)
    Cellular processes Cellular processes Other gas vesicle protein GvpN (TIGR02640; HMM-score: 11.9)
  • TheSEED: see INV104_07150
  • PFAM:
    P-loop_NTPase (CL0023) DNA_pol3_delta2; DNA polymerase III, delta subunit (PF13177; HMM-score: 149.7)
    and 30 more
    AAA; ATPase family associated with various cellular activities (AAA) (PF00004; HMM-score: 53.5)
    post-AAA (CL0604) DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III (PF12169; HMM-score: 34.2)
    P-loop_NTPase (CL0023) RuvB_N; Holliday junction DNA helicase RuvB P-loop domain (PF05496; HMM-score: 30.5)
    AAA_19; AAA domain (PF13245; HMM-score: 27.2)
    TIP49; TIP49 P-loop domain (PF06068; HMM-score: 26.7)
    AAA_22; AAA domain (PF13401; HMM-score: 25.8)
    AAA_5; AAA domain (dynein-related subfamily) (PF07728; HMM-score: 24.4)
    AAA_30; AAA domain (PF13604; HMM-score: 22.7)
    AAA_lid (CL0671) AAA_assoc_2; AAA C-terminal domain (PF16193; HMM-score: 22)
    P-loop_NTPase (CL0023) AAA_16; AAA ATPase domain (PF13191; HMM-score: 21)
    AAA_7; P-loop containing dynein motor region (PF12775; HMM-score: 20.9)
    AAA_14; AAA domain (PF13173; HMM-score: 20)
    ResIII; Type III restriction enzyme, res subunit (PF04851; HMM-score: 18.6)
    AAA_11; AAA domain (PF13086; HMM-score: 17.2)
    AAA_24; AAA domain (PF13479; HMM-score: 16.7)
    Sigma54_activat; Sigma-54 interaction domain (PF00158; HMM-score: 15.7)
    DNA_pol3_delta; DNA polymerase III, delta subunit (PF06144; HMM-score: 15.6)
    AAA_18; AAA domain (PF13238; HMM-score: 15.1)
    Torsin; Torsin (PF06309; HMM-score: 14.9)
    no clan defined EVC2_like; Ellis van Creveld protein 2 like protein (PF12297; HMM-score: 14.4)
    P-loop_NTPase (CL0023) PIF1; PIF1-like helicase (PF05970; HMM-score: 14.3)
    Mg_chelatase; Magnesium chelatase, subunit ChlI (PF01078; HMM-score: 14.2)
    TsaE; Threonylcarbamoyl adenosine biosynthesis protein TsaE (PF02367; HMM-score: 14)
    GT-A (CL0110) Glyco_tranf_2_5; Glycosyltransferase like family (PF13712; HMM-score: 14)
    no clan defined DUF1192; Protein of unknown function (DUF1192) (PF06698; HMM-score: 13.5)
    P-loop_NTPase (CL0023) AAA_2; AAA domain (Cdc48 subfamily) (PF07724; HMM-score: 13.1)
    T2SSE; Type II/IV secretion system protein (PF00437; HMM-score: 12.9)
    RNA_helicase; RNA helicase (PF00910; HMM-score: 12.6)
    Rad17; Rad17 P-loop domain (PF03215; HMM-score: 12.6)
    DUF815; Protein of unknown function (DUF815) (PF05673; HMM-score: 12.1)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9729
    • Cytoplasmic Membrane Score: 0.0077
    • Cell wall & surface Score: 0.0013
    • Extracellular Score: 0.0181
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.021694
    • TAT(Tat/SPI): 0.006954
    • LIPO(Sec/SPII): 0.001724
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000283791 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MYQALYRKYRSQNFSQLVGQEVVAKTLKQAVEQEKISHAYLFSGPRGTGKTSVAKIFAKAMNCPNQVGGEPCNNCYICQAVTDGSLEDVIEMDAASNNGVDEIREIRDKSTYAPSLARYKVYIIDEVHMLSTGAFNALLKTLEEPTQNVVFILATTELHKIPATILSRVQRFEFKSIKTQDIKEHIHYILEKENISSEPEAVEIIARRAEGGMRDALSILDQALSLTQGNELTTAISEEITGTISLSALDDYVAALSQQDVPKALSCLNLLFDNGKSMTRFVTDLLHYLRDLLIVQTGGENTHHSSVFVENLALPQKNLFEMIRLATVSLADIKSSLQPKIYAEMMTVRLAEIKPEPALSGAVENEIATLRQEVARLKQELSNVGAVPKQVAPAPSRPATGKTVYRVDRNKVQSILQEAVENPDLARQNLIRLQNAWGEVIESLGGPDKALLVGSQPVAANEHHAILAFESNFNAGQTMKRDNLNTMFGNILSQAAGFSPEILAISMEEWKEVRAAFSAKAKSSQTEKEVEESLIPEGFEFLADKVKVEED

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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