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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 11-FEB-2025

Summary[edit | edit source]

  • organism: Streptococcus pneumoniae INV104
  • locus tag: INV104_RS05340 [old locus tag: INV104_09190 ]
  • pan locus tag?: PNEUPAN002187000
  • symbol: INV104_RS05340
  • pan gene symbol?: immR
  • synonym:
  • product: helix-turn-helix domain-containing protein

Genome View[edit | edit source]

Gene[edit | edit source]

General[edit | edit source]

  • type: CDS
  • locus tag: INV104_RS05340 [old locus tag: INV104_09190 ]
  • symbol: INV104_RS05340
  • product: helix-turn-helix domain-containing protein
  • replicon: chromosome
  • strand: +
  • coordinates: 1006066..1006287
  • length: 222
  • essential: unknown other strains

Accession numbers[edit | edit source]

  • Location: NC_017591 (1006066..1006287) NCBI
  • BioCyc: INV104_RS05340 BioCyc
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_0951 PneumoBrowse

Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    ATGTACAGACGTTTGAGAGATTTGAGGGAAGATCACGATTTGACCCAAAAACAAATAGCT
    AAAATACTTTCGTTTACAAACTCAGCTTATGCTAAAATTGAACGGGGTGAGCATACGTTA
    ACAGCAGATGTATTGGTAACTCTCTCAAACTTTTACGATGTCAGTACAGACTACCTATTG
    GAATTGACAGATTTTCCTGATAAAATTCGCTTTAGAAAATAA
    60
    120
    180
    222

Protein[edit | edit source]

General[edit | edit source]

  • locus tag: INV104_RS05340 [old locus tag: INV104_09190 ]
  • symbol: INV104_RS05340
  • description: helix-turn-helix domain-containing protein
  • length: 73
  • theoretical pI: 7.68007
  • theoretical MW: 8696.82
  • GRAVY: -0.545205

Function[edit | edit source]

  • TIGRFAM:
    Signal transduction Regulatory functions DNA interactions transcriptional regulator, y4mF family (TIGR03070; HMM-score: 21.2)
    putative zinc finger/helix-turn-helix protein, YgiT family (TIGR03830; HMM-score: 20.1)
    Genetic information processing Mobile and extrachromosomal element functions Other addiction module antidote protein, HigA family (TIGR02607; HMM-score: 20)
    Signal transduction Regulatory functions DNA interactions addiction module antidote protein, HigA family (TIGR02607; HMM-score: 20)
    Signal transduction Regulatory functions Protein interactions addiction module antidote protein, HigA family (TIGR02607; HMM-score: 20)
    and 1 more
    Hypothetical proteins Conserved TIGR00270 family protein (TIGR00270; HMM-score: 12.8)
  • TheSEED: see INV104_09190
  • PFAM:
    HTH (CL0123) HTH_19; Helix-turn-helix domain (PF12844; HMM-score: 53.4)
    HTH_3; Helix-turn-helix (PF01381; HMM-score: 50.9)
    and 7 more
    HTH_31; Helix-turn-helix domain (PF13560; HMM-score: 39.2)
    HTH_37; Helix-turn-helix domain (PF13744; HMM-score: 21)
    HTH_26; Cro/C1-type HTH DNA-binding domain (PF13443; HMM-score: 18.3)
    TPR (CL0020) TAL_effector; TAL effector repeat (PF03377; HMM-score: 13.3)
    HTH (CL0123) MqsA_antitoxin; Antitoxin component of bacterial toxin-antitoxin system, MqsA (PF15731; HMM-score: 13.1)
    no clan defined Inhibitor_G39P; Loader and inhibitor of phage G40P (PF11417; HMM-score: 13)
    HTH (CL0123) Sigma70_r4; Sigma-70, region 4 (PF04545; HMM-score: 12.9)

Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9575
    • Cytoplasmic Membrane Score: 0.0053
    • Cell wall & surface Score: 0.0016
    • Extracellular Score: 0.0356
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.013629
    • TAT(Tat/SPI): 0.001189
    • LIPO(Sec/SPII): 0.000999
  • predicted transmembrane helices (TMHMM): 0

Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000286251 NCBI
  • UniProt:

Protein sequence[edit | edit source]

  • MYRRLRDLREDHDLTQKQIAKILSFTNSAYAKIERGEHTLTADVLVTLSNFYDVSTDYLLELTDFPDKIRFRK

Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

Expression & Regulation[edit | edit source]

Operon[edit | edit source]

Regulation[edit | edit source]

  • regulator:

Transcription[edit | edit source]

  • transcription start site:

Expression data[edit | edit source]

Biological Material[edit | edit source]

Mutants[edit | edit source]

Expression vector[edit | edit source]

lacZ fusion[edit | edit source]

GFP fusion[edit | edit source]

two-hybrid system[edit | edit source]

FLAG-tag construct[edit | edit source]

Antibody[edit | edit source]

Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

Literature[edit | edit source]

References[edit | edit source]

Relevant publications[edit | edit source]