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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 02-OCT-2023

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae BVJ1JL
  • locus tag: JN057_00937 [new locus tag: JN057_RS04560 ]
  • pan locus tag?: PNEUPAN001940000
  • symbol: ald_2
  • pan gene symbol?: ald
  • synonym:
  • product: Alanine dehydrogenase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: JN057_00937 [new locus tag: JN057_RS04560 ]
  • symbol: ald_2
  • product: Alanine dehydrogenase
  • replicon: chromosome
  • strand: -
  • coordinates: 884388..885227
  • length: 840
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: CP071871 (884388..885227) NCBI
  • BioCyc:
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_0841 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    ATGTTAATCGGAATCCCAAAAGAAATTAAAAATAACGAAAACCGTGTCGCCCTCACACCT
    GCAGGTGTTCATAGCTTAGTTAGTCGTGGTCATCGTGTCCTTATCGAAACAAATGCTGGT
    CTCGGTTCTGGCTTTACTGATGCTGACTATCAAAAGCAAGGAGCTGAGATTGTCGCTACT
    GCTGGTGAAGCTTGGGCAGCAGAGTTGGTTGTGAAAGTAAAAGAACCTTTAAGTTCTGAA
    TACGGTTACTTGCGCGACGATCTTCTTCTCTTCACCTACTTGCACATGGCCGCTGCTCCA
    GAATTAGCAGATGCTATGTTAGCAGCAAAAACAACAGGAATTGCCTATGAAACTGTTCGT
    GACAATCAAGGACAACTACCGCTCCTCGTTCCTATGAGTGAGGTTGCAGGTCGTATGGCT
    GTTCAAATCGGAGCTCACTTCCTTACTAAGCAAGCTGGTGGCTCTGGTGTTCTACTTGGT
    GGTGTACCAGGTGTTCCAAAAGGAAAAGTAACTATCATCGGTGATGGTGTCGTCGGTACA
    CATGCTGCCCGCATCGCCCTTGGTCTTGGTGCTCAAGTGACTATTTTAGATATTAGTGCC
    AAGCGTCTCTCAGTTCTAGAAGAAGTCTTTGGAAGTCAAATTCAAACTATTATATCTAAT
    TCATTCAACATTGAAGCAAGTGTGAGAGATGCTGATGTGGTGATTGGAGCCATTCTCATC
    CCTGGTGCAAAAGCACCGGAATTGGTGACAGATGAGATGGTCAAACAAATGCGTCCAGGC
    TCTGTATCGTTGACGTTGCTGTTGACCAAGGTGGCGTTATCGAAACAGCTGACCGTGTGA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: JN057_00937 [new locus tag: JN057_RS04560 ]
  • symbol: Ald_2
  • description: Alanine dehydrogenase
  • length: 279
  • theoretical pI: 6.36625
  • theoretical MW: 29195.7
  • GRAVY: 0.304659

⊟Function[edit | edit source]

  • reaction:
    EC 1.4.1.1?  ExPASy
    Alanine dehydrogenase L-alanine + H2O + NAD+ = pyruvate + NH3 + NADH
  • TIGRFAM:
    Metabolism Energy metabolism Amino acids and amines alanine dehydrogenase (TIGR00518; EC 1.4.1.1; HMM-score: 418.7)
    and 10 more
    Metabolism Energy metabolism Electron transport NAD(P)(+) transhydrogenase (AB-specific), alpha subunit (TIGR00561; EC 1.6.1.2; HMM-score: 119.3)
    dihydrolipoyl dehydrogenase (TIGR01350; EC 1.8.1.4; HMM-score: 17.1)
    6-hydroxycyclohex-1-ene-1-carbonyl-CoA dehydrogenase (TIGR03201; EC 1.1.1.-; HMM-score: 16.5)
    mycothione reductase (TIGR03452; EC 1.8.1.15; HMM-score: 15.7)
    Cellular processes Cellular processes Detoxification mercury(II) reductase (TIGR02053; EC 1.16.1.1; HMM-score: 15.2)
    nucleotide sugar dehydrogenase (TIGR03026; HMM-score: 15.2)
    Metabolism Energy metabolism Electron transport glutathione-disulfide reductase (TIGR01424; EC 1.8.1.7; HMM-score: 14.1)
    Cellular processes Cellular processes Cell division septum site-determining protein MinD (TIGR01968; HMM-score: 14)
    Cellular processes Cellular processes Biosynthesis of natural products 2,3-diaminopropionate biosynthesis protein SbnB (TIGR03944; HMM-score: 12.1)
    FAD dependent oxidoreductase TIGR03364 (TIGR03364; HMM-score: 11.5)
  • TheSEED:
  • PFAM:
    Form_Glyc_dh (CL0325) AlaDh_PNT_N; Alanine dehydrogenase/PNT, N-terminal domain (PF05222; HMM-score: 158.4)
    NADP_Rossmann (CL0063) AlaDh_PNT_C; Alanine dehydrogenase/PNT, C-terminal domain (PF01262; HMM-score: 149.6)
    and 8 more
    2-Hacid_dh_C; D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain (PF02826; HMM-score: 22)
    3HCDH_N; 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain (PF02737; HMM-score: 21.5)
    Pyr_redox; Pyridine nucleotide-disulphide oxidoreductase (PF00070; HMM-score: 21)
    Shikimate_DH; Shikimate / quinate 5-dehydrogenase (PF01488; HMM-score: 18.5)
    NAD_binding_7; Putative NAD(P)-binding (PF13241; HMM-score: 16.8)
    Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase (PF07992; HMM-score: 16.6)
    ADH_zinc_N; Zinc-binding dehydrogenase (PF00107; HMM-score: 15.5)
    UDPG_MGDP_dh_N; UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain (PF03721; HMM-score: 13)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.95
    • Cytoplasmic Membrane Score: 0.05
    • Cellwall Score: 0
    • Extracellular Score: 0
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9219
    • Cytoplasmic Membrane Score: 0.0214
    • Cell wall & surface Score: 0.0009
    • Extracellular Score: 0.0559
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.011119
    • TAT(Tat/SPI): 0.005091
    • LIPO(Sec/SPII): 0.001014
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: QTE32555 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MLIGIPKEIKNNENRVALTPAGVHSLVSRGHRVLIETNAGLGSGFTDADYQKQGAEIVATAGEAWAAELVVKVKEPLSSEYGYLRDDLLLFTYLHMAAAPELADAMLAAKTTGIAYETVRDNQGQLPLLVPMSEVAGRMAVQIGAHFLTKQAGGSGVLLGGVPGVPKGKVTIIGDGVVGTHAARIALGLGAQVTILDISAKRLSVLEEVFGSQIQTIISNSFNIEASVRDADVVIGAILIPGAKAPELVTDEMVKQMRPGSVSLTLLLTKVALSKQLTV

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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