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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 08-APR-2025

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae BVJ1JL
  • locus tag: JN057_RS05425 [old locus tag: JN057_01116 ]
  • pan locus tag?: PNEUPAN002135000
  • symbol: galE
  • pan gene symbol?: galE_1
  • synonym:
  • product: UDP-glucose 4-epimerase GalE

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: JN057_RS05425 [old locus tag: JN057_01116 ]
  • symbol: galE
  • product: UDP-glucose 4-epimerase GalE
  • replicon: chromosome
  • strand: +
  • coordinates: 1042685..1043713
  • length: 1029
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NZ_CP071871 (1042685..1043713) NCBI
  • BioCyc:
  • MicrobesOnline:
  • PneumoBrowse for strain D39V:

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    ATGAAATCATTATTAATAACAGGTGGAGCAGGATACATAGGATCACATACAGTTTTGGAC
    TTGTTAGATAATAATTATGAAGTAACAATCATTGATGATTTGAGTAACTCTAAGAAAAAA
    GTTATTGAGTCTATTAAGCAGATATCCAAGAAGAGTAGAAATCTTCATTTTTATAAAATT
    GATTTAAAAAATGAAGAAAAATTGGAAAATGTTTTTAAGAGACATAATTTTGATGGAGTA
    ATTCATTTTGCAGGGTATAAAGCTGTTGGAGAATCCGTGGTTGAACCATTGAAGTATTAT
    GAAAATAATTTATTATCAACTATAAATATTTTAAAACTAATGAAAAAATATAAGGTATTT
    AATTTTGTGTTTAGTTCATCAGCTACTGTATACGAAAGTACTCCTATCATGCCATTCTAT
    GAGACTAATCCATTAAAAGCTTCAAACCCGTATGGGAGAACAAAACAGTATATAGAAGTA
    CTTTTAAATGATTTGTTTATTTCGAATTCAAATTGGAAAATTGTTTGTCTGAGGTATTTT
    AATCCATTGGGTGCACATGAAAGTGGTGATTTAGGAGAGGATCCAAATGGAATTCCGAAT
    AATCTTGTTCCTTACATTACACAAGTTGCAATTGGAAAATTACCATATTTAAATATATTC
    GGAGTTGATTACAGTACTCCTGATGGGACTTGTATAAGGGACTATGTTCACGTTAACGAT
    TTAGCAGACGGACACAGAAAAGCATTAGAGTATATTTTTAATACAGATGAAGGTTTATAT
    GAAGTAATCAATTTAGGAAGTGGTGTTGGTTTTAGTGTATTTGAAATCCTACACAGCTTA
    GAGAGTGTCATAGGCTCGTATATTCCATATAAGATAACTTCAAGGAGAGCAGGAGATATG
    GACGTTTCAATTGCAGATATTTCAAAAGCAGAAGAGCTACTGGGATGGAAGCCAAGGTAT
    GATATTATGAAAATGTGCCAAGATACGTGGAAATGGCAACAGAAACATCCAAATGGATAT
    GATGACTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1029

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: JN057_RS05425 [old locus tag: JN057_01116 ]
  • symbol: GalE
  • description: UDP-glucose 4-epimerase GalE
  • length: 342
  • theoretical pI: 6.427
  • theoretical MW: 38918.1
  • GRAVY: -0.293567

⊟Function[edit | edit source]

  • reaction:
    EC 5.1.3.2?  ExPASy
    UDP-glucose 4-epimerase UDP-alpha-D-glucose = UDP-alpha-D-galactose
  • TIGRFAM:
    Metabolism Energy metabolism Sugars UDP-glucose 4-epimerase GalE (TIGR01179; EC 5.1.3.2; HMM-score: 418.3)
    and 17 more
    Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides dTDP-glucose 4,6-dehydratase (TIGR01181; EC 4.2.1.46; HMM-score: 108.7)
    NAD dependent epimerase/dehydratase, LLPSF_EDH_00030 family (TIGR04180; HMM-score: 97.3)
    Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides ADP-glyceromanno-heptose 6-epimerase (TIGR02197; EC 5.1.3.20; HMM-score: 80.1)
    Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides CDP-glucose 4,6-dehydratase (TIGR02622; EC 4.2.1.45; HMM-score: 70.1)
    Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides dTDP-4-dehydrorhamnose reductase (TIGR01214; EC 1.1.1.133; HMM-score: 37.1)
    Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides GDP-mannose 4,6-dehydratase (TIGR01472; EC 4.2.1.47; HMM-score: 34.2)
    hopanoid-associated sugar epimerase (TIGR03466; HMM-score: 32.3)
    UDP-N-acetylglucosamine 4,6-dehydratase (inverting) (TIGR03589; EC 4.2.1.115; HMM-score: 29)
    Hypothetical proteins Conserved TIGR01777 family protein (TIGR01777; HMM-score: 24.2)
    Metabolism Energy metabolism Fermentation acetoin reductases (TIGR02415; EC 1.1.1.-; HMM-score: 23.1)
    thioester reductase domain (TIGR01746; HMM-score: 22.8)
    UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase (TIGR04130; EC 4.2.1.-,5.1.3.-; HMM-score: 22.5)
    2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase (TIGR04316; EC 1.3.1.28; HMM-score: 20.2)
    Metabolism Fatty acid and phospholipid metabolism Biosynthesis 3-oxoacyl-[acyl-carrier-protein] reductase (TIGR01830; EC 1.1.1.100; HMM-score: 18.5)
    2-hydroxycyclohexanecarboxyl-CoA dehydrogenase (TIGR03206; EC 1.1.1.-; HMM-score: 13.2)
    L-aminoadipate-semialdehyde dehydrogenase (TIGR03443; EC 1.2.1.31; HMM-score: 13)
    3-hydroxybutyrate dehydrogenase (TIGR01963; HMM-score: 12.2)
  • TheSEED:
  • PFAM:
    NADP_Rossmann (CL0063) GDP_Man_Dehyd; GDP-mannose 4,6 dehydratase (PF16363; HMM-score: 203.1)
    Epimerase; NAD dependent epimerase/dehydratase family (PF01370; HMM-score: 168.4)
    and 10 more
    Polysacc_synt_2; Polysaccharide biosynthesis protein (PF02719; HMM-score: 58.6)
    3Beta_HSD; 3-beta hydroxysteroid dehydrogenase/isomerase family (PF01073; HMM-score: 50.9)
    RmlD_sub_bind; RmlD substrate binding domain (PF04321; HMM-score: 47.8)
    NAD_binding_10; NAD(P)H-binding (PF13460; HMM-score: 34.4)
    adh_short; short chain dehydrogenase (PF00106; HMM-score: 29.1)
    KR; KR domain (PF08659; HMM-score: 27.2)
    NAD_binding_4; Male sterility protein (PF07993; HMM-score: 26.3)
    Sacchrp_dh_NADP; Saccharopine dehydrogenase NADP binding domain (PF03435; HMM-score: 26.1)
    NmrA; NmrA-like family (PF05368; HMM-score: 17.6)
    3HCDH_N; 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain (PF02737; HMM-score: 17.4)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: unknown (no significant prediction)
    • Cytoplasmic Score: 2.5
    • Cytoplasmic Membrane Score: 2.5
    • Cellwall Score: 2.5
    • Extracellular Score: 2.5
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.8844
    • Cytoplasmic Membrane Score: 0.0604
    • Cell wall & surface Score: 0.0005
    • Extracellular Score: 0.0548
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.010396
    • TAT(Tat/SPI): 0.000201
    • LIPO(Sec/SPII): 0.005162
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000838665 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MKSLLITGGAGYIGSHTVLDLLDNNYEVTIIDDLSNSKKKVIESIKQISKKSRNLHFYKIDLKNEEKLENVFKRHNFDGVIHFAGYKAVGESVVEPLKYYENNLLSTINILKLMKKYKVFNFVFSSSATVYESTPIMPFYETNPLKASNPYGRTKQYIEVLLNDLFISNSNWKIVCLRYFNPLGAHESGDLGEDPNGIPNNLVPYITQVAIGKLPYLNIFGVDYSTPDGTCIRDYVHVNDLADGHRKALEYIFNTDEGLYEVINLGSGVGFSVFEILHSLESVIGSYIPYKITSRRAGDMDVSIADISKAEELLGWKPRYDIMKMCQDTWKWQQKHPNGYDD

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

  • PneumoExpress for strain D39V:

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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