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PangenomeTIGR4
serotype 4
D39serotype 2
D39Vserotype 2
Hungary19A-6serotype 19A
EF3030serotype 19F
670-6Bserotype 6B
6A-10serotype 6A
70585serotype 5
A026serotype 19F
A66serotype 3
AP200serotype 11A
ASP0581serotype 12F
ATCC 49619serotype 19F
ATCC 700669serotype 23F
BM6001serotype 19F
BVJ1JLserotype 1
CGSP14serotype 14
G54serotype 19F
HU-OHserotype 3
Hu15serotype 19A
Hu17serotype 19A
INV104serotype 1
INV200serotype 14
JJAserotype 14
MDRSPN001serotype 19F
NCTC7465serotype 1
NCTC7466serotype 2
NU83127serotype 4
OXC141serotype 3
P1031serotype 1
R6serotype 2
SP49serotype 19A
SPN032672serotype 1
SPN034156serotype 3
SPN034183serotype 3
SPN994038serotype 3
SPN994039serotype 3
SPNA45serotype 3
ST556serotype 19F
TCH8431/19Aserotype 19A
Taiwan19F-14serotype 19F
Xen35serotype 4
gamPNI0373serotype 1
NCBI: 05-OCT-2017
⊟Summary[edit | edit source]
- organism: Streptococcus pneumoniae MDRSPN001
- locus tag: MDRSPN_00273 [new locus tag: MDRSPN_RS01455 ]
- pan locus tag?: PNEUPAN001031000
- symbol: sulD
- pan gene symbol?: sulD
- synonyms: folB, folK
- product: bifunctional folate synthesis protein
⊟Genome View[edit | edit source]
⊟Gene[edit | edit source]
⊟General[edit | edit source]
- type: CDS
- locus tag: MDRSPN_00273 [new locus tag: MDRSPN_RS01455 ]
- symbol: sulD
- product: bifunctional folate synthesis protein
- replicon: chromosome
- strand: +
- coordinates: 264252..265064
- length: 813
- essential: unknown other strains
⊟Accession numbers[edit | edit source]
- Location: AP018391 (264252..265064) NCBI
- BioCyc:
- MicrobesOnline:
- PneumoBrowse for strain D39V: SPV_0272 PneumoBrowse
⊟Phenotype[edit | edit source]
Share your knowledge and add information here. [edit]
⊟DNA sequence[edit | edit source]
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781ATGGATCAACTGCAGATTAAGGATTTGGAAATGTTTGCCTATCATGGTCTTTTTCCTAGT
GAGAAAGAATTGGGGCAGAAATTTGTCGTTTCAGCCATCCTATCCTATGATATGACCAAG
GCAGCTACAGACTTGGATTTAACAGCCTCTGTCCATTACGGAGAATTGTGTCAGCAGTGG
ACGACTTGGTTTCAGGAAACGAGTGAAGATTTGATTGAAACGGTAGCCTATAAACTGGTG
GAACGTACCTTTGAGTTTTATCCTCTTGTCCAAGAAATGAAGTTGGAACTGAAAAAACCT
TGGGCACCGGTGCATTTGTCACTAGATACTTGCTCGGTAACCATTCATCGCCGCAAGCAA
CGAGCCTTTATCGCCTTAGGAAGCAATATGGGAGATAAACAAGCAAACTTGAAGCAAGCC
ATTGACAAACTGCGAGCTCGTGGCATCCATATTCTCAAAGAGTCCAGTGTCTTAGCGACG
GAGCCTTGGGGTGGAGTGGAGCAGGATAGCTTTGCCAATCAAGTGGTTGAGGTGGAAACC
TGGCTACCAGCACAAGACTTGTTAGAAACCTTGTTAGCCATTGAGTCAGAGCTGGGACGG
GTGAGAGAAGTGCATTGGGGACCTCGTTTGATTGATTTGGACTTGCTCTTTGTGGAGGAC
CAGATCCTTTATACAGACGACCTCATATTGCCTCATCCTTACATAGCGGAACGCCTTTTT
GTCCTTGAGTCCTTACAGGAAATTGCGCCTCATTTTATCCATCCGATATTAAAACAACCG
ATCCGCAACTTGTATGATGCTTTGAAAAAATAG60
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⊟Protein[edit | edit source]
⊟General[edit | edit source]
- locus tag: MDRSPN_00273 [new locus tag: MDRSPN_RS01455 ]
- symbol: SulD
- description: bifunctional folate synthesis protein
- length: 270
- theoretical pI: 4.86756
- theoretical MW: 31142.6
- GRAVY: -0.14
⊟Function[edit | edit source]
- TIGRFAM: Biosynthesis of cofactors, prosthetic groups, and carriers Folic acid 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase (TIGR01498; EC 2.7.6.3; HMM-score: 148.9)Biosynthesis of cofactors, prosthetic groups, and carriers Folic acid dihydroneopterin aldolase (TIGR00525; EC 4.1.2.25; HMM-score: 146.3)FolB domain (TIGR00526; HMM-score: 141)
- TheSEED: data available for D39, Hungary19A-6, TIGR4
- PFAM: no clan defined HPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK) (PF01288; HMM-score: 119.5)and 2 moreTHBO-biosyn (CL0334) FolB; Dihydroneopterin aldolase (PF02152; HMM-score: 91.1)no clan defined CENP-L; Kinetochore complex Sim4 subunit Fta1 (PF13092; HMM-score: 15.4)
⊟Structure, modifications & cofactors[edit | edit source]
- domains:
- modifications:
- cofactors:
- effectors:
⊟Localization[edit | edit source]
- PSORTb: Cytoplasmic
- Cytoplasmic Score: 7.5
- Cytoplasmic Membrane Score: 1.15
- Cellwall Score: 0.62
- Extracellular Score: 0.73
- Internal Helices: 0
- DeepLocPro: Cytoplasmic
- Cytoplasmic Score: 0.9993
- Cytoplasmic Membrane Score: 0.0002
- Cell wall & surface Score: 0
- Extracellular Score: 0.0004
- SignalP: no predicted signal peptide
- SP(Sec/SPI): 0.022996
- TAT(Tat/SPI): 0.002971
- LIPO(Sec/SPII): 0.000512
- predicted transmembrane helices (TMHMM): 0
⊟Accession numbers[edit | edit source]
- GI:
- RefSeq: BBA58479 NCBI
- UniProt:
⊟Protein sequence[edit | edit source]
- MDQLQIKDLEMFAYHGLFPSEKELGQKFVVSAILSYDMTKAATDLDLTASVHYGELCQQWTTWFQETSEDLIETVAYKLVERTFEFYPLVQEMKLELKKPWAPVHLSLDTCSVTIHRRKQRAFIALGSNMGDKQANLKQAIDKLRARGIHILKESSVLATEPWGGVEQDSFANQVVEVETWLPAQDLLETLLAIESELGRVREVHWGPRLIDLDLLFVEDQILYTDDLILPHPYIAERLFVLESLQEIAPHFIHPILKQPIRNLYDALKK
⊟Experimental data[edit | edit source]
- protein localization:
- interaction partners:
⊟Expression & Regulation[edit | edit source]
⊟Operon[edit | edit source]
⊟Regulation[edit | edit source]
- regulator:
⊟Expression data[edit | edit source]
- PneumoExpress for strain D39V: SPV_0272 PneumoExpress
⊟Biological Material[edit | edit source]
⊟Mutants[edit | edit source]
⊟Expression vector[edit | edit source]
⊟lacZ fusion[edit | edit source]
⊟GFP fusion[edit | edit source]
⊟two-hybrid system[edit | edit source]
⊟FLAG-tag construct[edit | edit source]
⊟Antibody[edit | edit source]
⊟Other Information[edit | edit source]
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