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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 05-OCT-2017

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae MDRSPN001
  • locus tag: MDRSPN_00375 [new locus tag: MDRSPN_RS02010 ]
  • pan locus tag?: PNEUPAN001288000
  • symbol: fabK
  • pan gene symbol?: fabK
  • synonym:
  • product: 2-nitropropane dioxygenase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: MDRSPN_00375 [new locus tag: MDRSPN_RS02010 ]
  • symbol: fabK
  • product: 2-nitropropane dioxygenase
  • replicon: chromosome
  • strand: +
  • coordinates: 373548..374522
  • length: 975
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

  • Location: AP018391 (373548..374522) NCBI
  • BioCyc:
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_0382 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    ATGAAAACGCGTATTACAGAATTATTGAAGATTGACTATCCTATTTTCCAAGGAGGGATG
    GCCTGGGTTGCTGATGGTGATTTGGCAGGGGCTGTTTCCAAGGCTGGAGGATTAGGAATT
    ATCGGTGGGGGAAATGCCCCGAAAGAAGTTGTCAAGGCCAATATTGATAAAATCAAATCA
    TTGACTGATAAACCCTTTGGGGTCAACATCATGCTCTTATCTCCCTTTGTGGAAGATATC
    GTGGATCTCGTTATTGAAGAAGGTGTTAAAGTTGTCACAACAGGAGCAGGAAATCCAAGC
    AAGTATATGGAACGTTTCCATGAAGCTGGGATAATCGTTATTCCTGTTGTTCCTAGTGTC
    GCTTTAGCTAAACGCATGGAAAAAATCGGTGCAGACGCTGTTATTGCAGAAGGAATGGAA
    GCTGGGGGGCATATCGGTAAATTAACAACCATGACCTTGGTGCGACAGGTAGCCACAGCT
    ATATCTATTCCTGTTATTGCTGCAGGAGGAATTGCGGATGGTGAAGGTGCTGCGGCTGGC
    TTTATGCTAGGTGCAGAGGCTGTACAGGTGGGGACACGGTTTGTAGTTGCAAAAGAGTCG
    AATGCCCATCCAAACTACAAGGAGAAAATTTTAAAAGCAAGGGATATTGACACTACGATT
    TCAGCTCAGCACTTTGGTCATGCTGTTCGTGCTATTAAAAATCAGTTGACTAGAGATTTT
    GAACTGGCTGAAAAAGATGCCTTTAAGCAGGAAGATCCTGATTTAGAAATCTTTGAACAA
    ATGGGAGCAGGTGCCCTAGCCAAAGCAGTTGTTCACGGTGATGTGGATGGTGGCTCTGTC
    ATGGCAGGTCAAATCGCAGGGCTTGTTTCTAAAGAAGAAACAGCTGAAGAAATCCTAAAA
    GATTTGTATTACGGAGCCGCTAAGAAAATTCAAGAAGAAGCCTCTCGCTGGACAGGAGTT
    GTAAGAAATGACTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    975

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: MDRSPN_00375 [new locus tag: MDRSPN_RS02010 ]
  • symbol: FabK
  • description: 2-nitropropane dioxygenase
  • length: 324
  • theoretical pI: 5.12637
  • theoretical MW: 34177.1
  • GRAVY: 0.0709877

⊟Function[edit | edit source]

  • TIGRFAM:
    putative enoyl-[acyl-carrier-protein] reductase II (TIGR03151; EC 1.3.1.-; HMM-score: 505.1)
    and 8 more
    PfaD family protein (TIGR02814; HMM-score: 38.1)
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Purine ribonucleotide biosynthesis inosine-5'-monophosphate dehydrogenase (TIGR01302; EC 1.1.1.205; HMM-score: 36.8)
    dihydroorotate dehydrogenase family protein (TIGR01037; EC 1.3.-.-; HMM-score: 29.9)
    Metabolism Amino acid biosynthesis Histidine family imidazoleglycerol phosphate synthase, cyclase subunit (TIGR00735; HMM-score: 28)
    glycosyl amidation-associated protein WbuZ (TIGR03572; HMM-score: 21.8)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Other isopentenyl-diphosphate delta-isomerase, type 2 (TIGR02151; EC 5.3.3.2; HMM-score: 17.9)
    Metabolism Amino acid biosynthesis Histidine family 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase (TIGR00007; EC 5.3.1.16; HMM-score: 17.3)
    Unknown function General putative TIM-barrel protein, nifR3 family (TIGR00737; HMM-score: 13.4)
  • TheSEED: data available for D39, Hungary19A-6, TIGR4
  • PFAM:
    TIM_barrel (CL0036) NMO; Nitronate monooxygenase (PF03060; HMM-score: 251.9)
    and 9 more
    IMPDH; IMP dehydrogenase / GMP reductase domain (PF00478; HMM-score: 43.7)
    ThiG; Thiazole biosynthesis protein ThiG (PF05690; HMM-score: 30.8)
    DHO_dh; Dihydroorotate dehydrogenase (PF01180; HMM-score: 27.6)
    His_biosynth; Histidine biosynthesis protein (PF00977; HMM-score: 23.3)
    DUF561; Protein of unknown function (DUF561) (PF04481; HMM-score: 18.7)
    FMN_dh; FMN-dependent dehydrogenase (PF01070; HMM-score: 17.4)
    PK_TIM (CL0151) PEP_hydrolase; Phosphoenolpyruvate hydrolase-like (PF09370; HMM-score: 16.4)
    TIM_barrel (CL0036) Glu_synthase; Conserved region in glutamate synthase (PF01645; HMM-score: 12.4)
    Dus; Dihydrouridine synthase (Dus) (PF01207; HMM-score: 12)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.077874
    • TAT(Tat/SPI): 0.011784
    • LIPO(Sec/SPII): 0.004983
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: BBA58581 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MKTRITELLKIDYPIFQGGMAWVADGDLAGAVSKAGGLGIIGGGNAPKEVVKANIDKIKSLTDKPFGVNIMLLSPFVEDIVDLVIEEGVKVVTTGAGNPSKYMERFHEAGIIVIPVVPSVALAKRMEKIGADAVIAEGMEAGGHIGKLTTMTLVRQVATAISIPVIAAGGIADGEGAAAGFMLGAEAVQVGTRFVVAKESNAHPNYKEKILKARDIDTTISAQHFGHAVRAIKNQLTRDFELAEKDAFKQEDPDLEIFEQMGAGALAKAVVHGDVDGGSVMAGQIAGLVSKEETAEEILKDLYYGAAKKIQEEASRWTGVVRND

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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