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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 05-OCT-2017

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae MDRSPN001
  • locus tag: MDRSPN_00466 [new locus tag: MDRSPN_RS02495 ]
  • pan locus tag?: PNEUPAN003150000
  • symbol: mvaS
  • pan gene symbol?: mvaS
  • synonym:
  • product: hydroxymethylglutaryl-CoA synthase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: MDRSPN_00466 [new locus tag: MDRSPN_RS02495 ]
  • symbol: mvaS
  • product: hydroxymethylglutaryl-CoA synthase
  • replicon: chromosome
  • strand: +
  • coordinates: 472694..473866
  • length: 1173
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

  • Location: AP018391 (472694..473866) NCBI
  • BioCyc:
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_1537 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    ATGACAATCGGTATTGATAAGATTGGTTTTGCGACCAGTCAATATGTCTTGAAATTACAA
    GACTTAGCAGAAGCGAGGGGAATTGACCCTGAAAAATTAAGTAAAGGACTCTTACTCAAG
    GAATTGAGTATTGCGCCCCTAACTGAGGACATCGTGACCTTGGCGGCCAGTGCTAGTGAC
    TCTATTTTAACTGAGCAAGAAAGACAAGAAGTTGACATGGTCATTGTGGCGACCGAGTCA
    GGAATTGACCAGAGTAAGGCTGCGGCCGTCTTTGTGCATGGCTTGCTGGGCATCCAGCCC
    TTTGCTCGTAGTTTCGAGATTAAAGAAGCCTGCTATGGGGCGACTGCTGCCCTCCATTAT
    GCCAAATTGCATGTGGAAAATTCTCCGGAGTCCAAGGTCTTGGTCATTGCAAGTGATATT
    GCCAAATACGGTATTGAAACTCCGGGAGAACCCACTCAGGGTGCCGGAAGTGTGGCTATG
    TTGATTACACAAAATCCACGCATGATGGCCTTTAATAATGACAATGTAGCTCAGACCCGT
    GACATCATGGATTTCTGGCGACCAAATTACTCGACAACTCCTTATGTAAATGGTGTCTAT
    TCTACCCAACAATACTTGGATAGTTTGAAAACGACTTGGCTTGAATATCAAAAACGCTAC
    CAGCTTACTTTGGATGATTTTGCGGCTGTTTGTTTCCACTTGCCTTATCCTAAATTAGCG
    CTAAAAGGCTTGAAAAAAATCATGGATAAGAGCCTGCCTCAAGAGAAAAAAGACCTCTTA
    CAAAAGCATTTTGACCAGTCTATTCTCTACAGTCAAAAGGTGGGGAATATCTACACAGGT
    TCACTTTTCCTTGGACTTTTGTCTCTCTTGGAAAATACAGATAGCTTGAAAGCTGGGGAT
    AAAATCGCCCTTTATAGTTACGGAAGTGGAGCTGTGGCTGAGTTCTTCAGTGGTGAATTG
    GTTGAAGGATATGAAGCTTATCTGGATAAAGACCGTTTGAACAAGCTCAACCAACGAACT
    GCCCTGTCTGTTGCTGACTATGAAAAAGTCTTCTTTGAGGAAGTAGACTTAGATGAAACA
    AATTGTGCCCAGTTTGCTGGCTATGAAAATCAAGATTTTGCCTTGGTTGAAATTGTCGAC
    CACCAACGCCGTTATAGCAAGGTTGAAAAATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1173

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: MDRSPN_00466 [new locus tag: MDRSPN_RS02495 ]
  • symbol: MvaS
  • description: hydroxymethylglutaryl-CoA synthase
  • length: 390
  • theoretical pI: 4.70887
  • theoretical MW: 43506.1
  • GRAVY: -0.209487

⊟Function[edit | edit source]

  • TIGRFAM:
    hydroxymethylglutaryl-CoA synthase (TIGR01835; EC 2.3.3.10; HMM-score: 590.3)
    and 3 more
    hydroxymethylglutaryl-CoA synthase (TIGR01833; EC 2.3.3.10; HMM-score: 136.6)
    Metabolism Fatty acid and phospholipid metabolism Biosynthesis putative hydroxymethylglutaryl-CoA synthase (TIGR00748; EC 2.3.3.10; HMM-score: 88.6)
    Metabolism Fatty acid and phospholipid metabolism Biosynthesis 3-oxoacyl-[acyl-carrier-protein] synthase III (TIGR00747; EC 2.3.1.180; HMM-score: 41.9)
  • TheSEED: data available for D39, Hungary19A-6, TIGR4
  • PFAM:
    Thiolase (CL0046) HMG_CoA_synt_C; Hydroxymethylglutaryl-coenzyme A synthase C terminal (PF08540; HMM-score: 83.5)
    and 5 more
    HMG_CoA_synt_N; Hydroxymethylglutaryl-coenzyme A synthase N terminal (PF01154; HMM-score: 44.2)
    Chal_sti_synt_N; Chalcone and stilbene synthases, N-terminal domain (PF00195; HMM-score: 30.6)
    ACP_syn_III; 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III (PF08545; HMM-score: 20.9)
    ACP_syn_III_C; 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal (PF08541; HMM-score: 18.3)
    Amidohydrolase (CL0034) CpsB_CapC; Capsular polysaccharide synthesis, CpsB/CapC (PF19567; HMM-score: 11.4)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9509
    • Cytoplasmic Membrane Score: 0.0105
    • Cell wall & surface Score: 0.0013
    • Extracellular Score: 0.0373
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.004115
    • TAT(Tat/SPI): 0.00065
    • LIPO(Sec/SPII): 0.000639
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: BBA58672 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MTIGIDKIGFATSQYVLKLQDLAEARGIDPEKLSKGLLLKELSIAPLTEDIVTLAASASDSILTEQERQEVDMVIVATESGIDQSKAAAVFVHGLLGIQPFARSFEIKEACYGATAALHYAKLHVENSPESKVLVIASDIAKYGIETPGEPTQGAGSVAMLITQNPRMMAFNNDNVAQTRDIMDFWRPNYSTTPYVNGVYSTQQYLDSLKTTWLEYQKRYQLTLDDFAAVCFHLPYPKLALKGLKKIMDKSLPQEKKDLLQKHFDQSILYSQKVGNIYTGSLFLGLLSLLENTDSLKAGDKIALYSYGSGAVAEFFSGELVEGYEAYLDKDRLNKLNQRTALSVADYEKVFFEEVDLDETNCAQFAGYENQDFALVEIVDHQRRYSKVEK

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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