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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 05-OCT-2017

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae MDRSPN001
  • locus tag: MDRSPN_00991 [new locus tag: MDRSPN_RS05190 ]
  • pan locus tag?: PNEUPAN002388000
  • symbol: acoB
  • pan gene symbol?: acoB
  • synonym:
  • product: TPP-dependent acetoin dehydrogenase complex, E1 protein subunit beta

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: MDRSPN_00991 [new locus tag: MDRSPN_RS05190 ]
  • symbol: acoB
  • product: TPP-dependent acetoin dehydrogenase complex, E1 protein subunit beta
  • replicon: chromosome
  • strand: -
  • coordinates: 1011528..1012520
  • length: 993
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: AP018391 (1011528..1012520) NCBI
  • BioCyc:
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_1027 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    ATGGAAACAAAAACAATGTCCTTCCGTGACACCATTATCCTTGCTATGTCTGAGGAAATG
    CGTCGCGATGAAAATGTGTTCTTGATGGGAGAAGATGTCGGTGTCTTTGGAGGAGACTTC
    GGTACTTCTGTCGGAATGCTTGAAGAATTTGGTCCAGAACGTGTCCGTGACTGTCCGATT
    TCTGAAGCTGCCATCTCTGGAGCAGCAGCCGGAGCAGCCATGACAGGACTACGTCCAATC
    GTCGATATGACCTTCATGGACTTCTCTGTTATTGCCATGGACAATATCGTCAACCAAGCC
    GCTAAAACACGTTACATGTTTGGTGGTAAGGGGCAGGTTCCAATGACTGTCCGTTGTGCA
    GCAGGTAACGGAGTTGGTTCTGCAGCCCAGCACTCGCAATCACTAGAGTCTTGGTTTACT
    CACATTCCTGGTCTTAAGGTTGTGGCACCAGGTACACCTGCGGACATGAAAGGATTGCTT
    AAGTCTTCTATCCGTGATAATAACCCTGTTATTATTCTTGAGTACAAGTCAGAATTTAAC
    CAAAAAGGGGAAGTGCCAGTTGATCCAGACTACACAATTCCACTTGGGGTTGGTGAAATC
    AAACGCCAAGGAACGGATGTAACAGTTGTTACTTATGGAAAAATGCTTCGCCGTGTGGTT
    CAAGCTGCTGAAGAATTAGCAGAAGAAGGAATTTCAGTTGAAATTGTTGACCCACGTACC
    CTTGTTCCGCTTGATAAGGATATCATCATAAACTCAGTGAAGAAGACTGGTAAGGTTGTT
    CTGGTCAACGATGCCCACAAAACAAGTGGCTATATCGGTGAAATTTCAGCTATTATTTCA
    GAATCAGAAGCATTTGACTATCTAGATGCACCAATTCGCCGTTGTGCAGGAGAAGATGTG
    CCGATGCCTTATGCACAAAACCTAGAAAATGCAATGATTCCAACAGTTGAAAGTATCAAA
    GATGCAATCCGAAAAACTTATAACAAAGAATAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    993

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: MDRSPN_00991 [new locus tag: MDRSPN_RS05190 ]
  • symbol: AcoB
  • description: TPP-dependent acetoin dehydrogenase complex, E1 protein subunit beta
  • length: 330
  • theoretical pI: 4.58851
  • theoretical MW: 35819.8
  • GRAVY: -0.105455

⊟Function[edit | edit source]

  • TIGRFAM:
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Other 1-deoxy-D-xylulose-5-phosphate synthase (TIGR00204; EC 2.2.1.7; HMM-score: 82.2)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Thiamine 1-deoxy-D-xylulose-5-phosphate synthase (TIGR00204; EC 2.2.1.7; HMM-score: 82.2)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Pyridoxine 1-deoxy-D-xylulose-5-phosphate synthase (TIGR00204; EC 2.2.1.7; HMM-score: 82.2)
    and 2 more
    2-oxoacid:acceptor oxidoreductase, alpha subunit (TIGR03710; HMM-score: 24.9)
    indolepyruvate ferredoxin oxidoreductase, alpha subunit (TIGR03336; EC 1.2.7.8; HMM-score: 9.6)
  • TheSEED: data available for D39, TIGR4
  • PFAM:
    THDP-binding (CL0254) Transket_pyr; Transketolase, pyrimidine binding domain (PF02779; HMM-score: 163.2)
    TKC_like (CL0591) Transketolase_C; Transketolase, C-terminal domain (PF02780; HMM-score: 138)
    and 1 more
    PFOR_II; Pyruvate:ferredoxin oxidoreductase core domain II (PF17147; HMM-score: 25.3)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9771
    • Cytoplasmic Membrane Score: 0.0054
    • Cell wall & surface Score: 0.0002
    • Extracellular Score: 0.0173
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.011454
    • TAT(Tat/SPI): 0.001547
    • LIPO(Sec/SPII): 0.000672
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: BBA59194 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • METKTMSFRDTIILAMSEEMRRDENVFLMGEDVGVFGGDFGTSVGMLEEFGPERVRDCPISEAAISGAAAGAAMTGLRPIVDMTFMDFSVIAMDNIVNQAAKTRYMFGGKGQVPMTVRCAAGNGVGSAAQHSQSLESWFTHIPGLKVVAPGTPADMKGLLKSSIRDNNPVIILEYKSEFNQKGEVPVDPDYTIPLGVGEIKRQGTDVTVVTYGKMLRRVVQAAEELAEEGISVEIVDPRTLVPLDKDIIINSVKKTGKVVLVNDAHKTSGYIGEISAIISESEAFDYLDAPIRRCAGEDVPMPYAQNLENAMIPTVESIKDAIRKTYNKE

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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