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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 17-DEC-2024

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae MDRSPN001
  • locus tag: MDRSPN_RS03050 [old locus tag: MDRSPN_00565 ]
  • pan locus tag?: PNEUPAN001651000
  • symbol: MDRSPN_RS03050
  • pan gene symbol?: ctpA
  • synonym:
  • product: heavy metal translocating P-type ATPase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: MDRSPN_RS03050 [old locus tag: MDRSPN_00565 ]
  • symbol: MDRSPN_RS03050
  • product: heavy metal translocating P-type ATPase
  • replicon: chromosome
  • strand: +
  • coordinates: 582276..584519
  • length: 2244
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NZ_AP018391 (582276..584519) NCBI
  • BioCyc:
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_0635 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    1741
    1801
    1861
    1921
    1981
    2041
    2101
    2161
    2221
    ATGACTGAAATTGTAAAAGCAAGTCTTGAAAATGGCATTCAAAAAATCCATATCCGCGCT
    GAAAAAGGCTACCATCCAGCCCACATTCAACTGCAAAAAGGAGTTCCTACTGAGATCACC
    TTTCACCGTGTGACACCTTCAAACTGTTATAAGGAAATTCTGTTTGAAGAAGAAGGCATC
    TTGGAACCAATCGGCGTAGATGAGGAGAAAGTCATTCGTTTTACACCTCAAGAATTAGGT
    CAACATGAATTTTCTTGTGGTATGAAGATGCAAAAGGGAAGTTATACAGTTGTTGAGAAG
    ACTCGAAAATCTCTATCACTCCTCCAGCGTTTTTGGATTACTAGTATCTTTACTGTGCCT
    CTTGTGATCCTCATGATTGGGATGTCGACAGGAGGAATTAGTCACCAAGTCATGCGTTGG
    GGCACCTTTTTAGCCACAACACCGATTATGCTAGTAGCAGGTGGTCCTTATATCCAAAGT
    GCTTGGGCTAGTTTTAAAAAGCACAATGCCAACATGGATACCTTGGTTGCTCTGGGAACC
    CTAGTGGCCTATTTCTATAGCTTAGTTGCCCTCTTCGCTGGCCTCCCCGTTTACTTTGAA
    AGTGCTGCATTTATCTTCTTCTTCGTTCTTATGGGAGCCGTTTTTGAGGAGAAAATGCGG
    AAAAATACTTCCCAAGCTGTGGAGAAATTACTTGACTTGCAAGCTAAAACTGCAGAAGTC
    TTGCGTGAGGATAACTATGTTCAAGTCCCTTTGGAGCAAGTCAAGGTAGGTGACCTGATT
    CGAGTGCGTCCCGGTGAAAAGATTGCGGTTGATGGTGTCGTAGTAGAAGGTATCTCTAGT
    ATTGATGAGTCTATGGTGACAGGTGAGAGTCTGCCTGTGGACAAGACAGTTGGAGATACC
    GTCATTGGTTCAACCATCAATCATAGTGGAACACTTGTTTTTAGAGCAGAAAAAGTTGGT
    TCAGAGACTGTTTTGGCTCAGATTGTGGATTTTGTGAAGAAAGCTCAGACAAGTCGTGCG
    CCGATTCAGGACTTGACGGATAAAATTTCAGGGATTTTTGTTCCAGCAGTTGTCATTTTA
    GGGATTGTGACCTTTTGGGTTTGGTTCGTCTTGCTCAGGGATAGTGTAGTTGTGCTTGGA
    GCGAGCTTTGTGTCTTCGCTTCTCTATGGAGTAGCAGTTCTGATTATTGCCTGCCCTTGT
    GCATTGGGACTTGCAACACCGACAGCCCTTATGGTGGGGACAGGTCGCAGTGCCAAGATG
    GGAGTTCTCCTCAAAAATGGAACTGTTCTACAGGAAATCCAGAAAGTCCAAACCATTGTC
    TTTGATAAAACAGGGACTTTGACTGAAGGGAAACCTGTGGTCACAGATATCATCGGCGAC
    GAAGTAGAAGTGCTTGGATTGGCAGCTTCCTTGGAAGAAGCTTCTCAACACCCACTGGCT
    GAAGCCGTTGTGAAACGAGCGAGTGAAGCTGGACTTGAGCTTCAAACTGTTGAAAATTTC
    CAAGCCTTGCACGGAAAAGGTGTCTCAGGGCAAATCAATGGAAAACAAGTTCTGCTTGGA
    AATGCTAAAATGCTGGATGGCATGAACATTTCTAGCACTTATCAAGAAAAACTAGAAGAA
    CTGGAAAAAGAAGCTAAGACAGTTGTGTTCTTGGCTGTTGAGAATGAAATCAAAGGCTTG
    CTTGCTCTGCAAGATATTCCTAAGGAAAATGCTAAGCTTGCCATCAGTCAGTTGAAAAAA
    CGAGGTCTTAAAACAGTCATGCTGACAGGAGACAATGCTGGTGTGGCGCGTGCTATTGCA
    GATCAAATCGGAATCGAAGAGGTCATTGCAGGTGTCTTACCAGAAGAAAAAGCCCATGAA
    ATCCATAAACTACAAGCGACTGGCAAAGTAGCCTTTGTTGGGGACGGTATCAATGACGCT
    CCTGCCCTTAGTGTAGCAGATGTGGGGATTGCTATGGGAGCTGGAACAGATATCGCTATC
    GAGTCAGCAGATTTGGTGTTGACAACCAATAACCTCCTAGGAGTGGTTCGTGCTTTTGAC
    ATGAGTAAGAAAACCTTTAATCGAATTCTGCTCAATCTTTTCTGGGCCTTTATCTACAAT
    GTTGCCGGAATTCCGATTGCAGCAGGAGTCTTTTCAGGTGTTGGACTGGCTCTCAACCCA
    GAATTGGCAGGTCTAGCCATGGCCTTTAGTTCTGTATCTGTTCTGACCAGTTCCCTTCTG
    TTAAATTTTAGTAAAATAGACTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1680
    1740
    1800
    1860
    1920
    1980
    2040
    2100
    2160
    2220
    2244

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: MDRSPN_RS03050 [old locus tag: MDRSPN_00565 ]
  • symbol: MDRSPN_RS03050
  • description: heavy metal translocating P-type ATPase
  • length: 747
  • theoretical pI: 5.57155
  • theoretical MW: 80368.1
  • GRAVY: 0.329853

⊟Function[edit | edit source]

  • TIGRFAM:
    heavy metal translocating P-type ATPase (TIGR01525; EC 3.6.3.-; HMM-score: 636.9)
    Cellular processes Cellular processes Detoxification copper-translocating P-type ATPase (TIGR01511; EC 3.6.3.4; HMM-score: 623)
    Metabolism Transport and binding proteins Cations and iron carrying compounds copper-translocating P-type ATPase (TIGR01511; EC 3.6.3.4; HMM-score: 623)
    and 21 more
    Metabolism Transport and binding proteins Cations and iron carrying compounds cadmium-translocating P-type ATPase (TIGR01512; EC 3.6.3.3; HMM-score: 394.1)
    HAD ATPase, P-type, family IC (TIGR01494; EC 3.6.3.-; HMM-score: 318.7)
    plasma-membrane proton-efflux P-type ATPase (TIGR01647; EC 3.6.3.6; HMM-score: 183.4)
    Metabolism Transport and binding proteins Cations and iron carrying compounds K+-transporting ATPase, B subunit (TIGR01497; EC 3.6.3.12; HMM-score: 174.8)
    calcium-translocating P-type ATPase, PMCA-type (TIGR01517; EC 3.6.3.8; HMM-score: 139.9)
    Metabolism Transport and binding proteins Cations and iron carrying compounds calcium-translocating P-type ATPase, SERCA-type (TIGR01116; EC 3.6.3.8; HMM-score: 130.5)
    calcium-transporting P-type ATPase, PMR1-type (TIGR01522; EC 3.6.3.8; HMM-score: 128.3)
    Metabolism Transport and binding proteins Cations and iron carrying compounds magnesium-translocating P-type ATPase (TIGR01524; EC 3.6.3.2; HMM-score: 104.7)
    Metabolism Energy metabolism ATP-proton motive force interconversion Na,H/K antiporter P-type ATPase, alpha subunit (TIGR01106; EC 3.6.3.-; HMM-score: 99.9)
    P-type ATPase of unknown pump specificity (type V) (TIGR01657; HMM-score: 94)
    potassium/sodium efflux P-type ATPase, fungal-type (TIGR01523; EC 3.6.3.-; HMM-score: 92.2)
    Unknown function Enzymes of unknown specificity Cof-like hydrolase (TIGR00099; HMM-score: 36.7)
    phosphoglycolate phosphatase, TA0175-type (TIGR01487; EC 3.1.3.18; HMM-score: 28)
    Metabolism Amino acid biosynthesis Serine family phosphoserine phosphatase SerB (TIGR00338; EC 3.1.3.3; HMM-score: 24.7)
    Unknown function Enzymes of unknown specificity HAD phosphoserine phosphatase-like hydrolase, family IB (TIGR01488; HMM-score: 23.1)
    phosphoserine phosphatase-like hydrolase, archaeal (TIGR01491; HMM-score: 20.8)
    sucrose-phosphate phosphatase subfamily (TIGR01482; EC 3.1.3.-; HMM-score: 16.5)
    Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase, YrbI family (TIGR01670; EC 3.1.3.45; HMM-score: 15.5)
    Unknown function Enzymes of unknown specificity HAD hydrolase, family IIB (TIGR01484; HMM-score: 14.7)
    Unknown function Enzymes of unknown specificity HAD hydrolase, family IB (TIGR01490; HMM-score: 12.3)
    phospholipid-translocating P-type ATPase, flippase (TIGR01652; EC 3.6.3.1; HMM-score: 11.5)
  • TheSEED: data available for D39, Hungary19A-6, TIGR4
  • PFAM:
    no clan defined E1-E2_ATPase; E1-E2 ATPase (PF00122; HMM-score: 184)
    HAD (CL0137) Hydrolase; haloacid dehalogenase-like hydrolase (PF00702; HMM-score: 156.7)
    and 3 more
    Hydrolase_3; haloacid dehalogenase-like hydrolase (PF08282; HMM-score: 38.5)
    CU_oxidase (CL0026) Cupredoxin_1; Cupredoxin-like domain (PF13473; HMM-score: 37.8)
    HAD (CL0137) HAD; haloacid dehalogenase-like hydrolase (PF12710; HMM-score: 21.1)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 10
    • Cellwall Score: 0
    • Extracellular Score: 0
    • Internal Helices: 8
  • DeepLocPro: Cytoplasmic Membrane
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 0.9992
    • Cell wall & surface Score: 0
    • Extracellular Score: 0.0008
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.002146
    • TAT(Tat/SPI): 0.000204
    • LIPO(Sec/SPII): 0.00037
  • predicted transmembrane helices (TMHMM): 8

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_120164182 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MTEIVKASLENGIQKIHIRAEKGYHPAHIQLQKGVPTEITFHRVTPSNCYKEILFEEEGILEPIGVDEEKVIRFTPQELGQHEFSCGMKMQKGSYTVVEKTRKSLSLLQRFWITSIFTVPLVILMIGMSTGGISHQVMRWGTFLATTPIMLVAGGPYIQSAWASFKKHNANMDTLVALGTLVAYFYSLVALFAGLPVYFESAAFIFFFVLMGAVFEEKMRKNTSQAVEKLLDLQAKTAEVLREDNYVQVPLEQVKVGDLIRVRPGEKIAVDGVVVEGISSIDESMVTGESLPVDKTVGDTVIGSTINHSGTLVFRAEKVGSETVLAQIVDFVKKAQTSRAPIQDLTDKISGIFVPAVVILGIVTFWVWFVLLRDSVVVLGASFVSSLLYGVAVLIIACPCALGLATPTALMVGTGRSAKMGVLLKNGTVLQEIQKVQTIVFDKTGTLTEGKPVVTDIIGDEVEVLGLAASLEEASQHPLAEAVVKRASEAGLELQTVENFQALHGKGVSGQINGKQVLLGNAKMLDGMNISSTYQEKLEELEKEAKTVVFLAVENEIKGLLALQDIPKENAKLAISQLKKRGLKTVMLTGDNAGVARAIADQIGIEEVIAGVLPEEKAHEIHKLQATGKVAFVGDGINDAPALSVADVGIAMGAGTDIAIESADLVLTTNNLLGVVRAFDMSKKTFNRILLNLFWAFIYNVAGIPIAAGVFSGVGLALNPELAGLAMAFSSVSVLTSSLLLNFSKID

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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