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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 17-DEC-2024

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae MDRSPN001
  • locus tag: MDRSPN_RS05645 [old locus tag: MDRSPN_01074 ]
  • pan locus tag?: PNEUPAN001900000
  • symbol: MDRSPN_RS05645
  • pan gene symbol?: lys1
  • synonym:
  • product: saccharopine dehydrogenase family protein

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: MDRSPN_RS05645 [old locus tag: MDRSPN_01074 ]
  • symbol: MDRSPN_RS05645
  • product: saccharopine dehydrogenase family protein
  • replicon: chromosome
  • strand: -
  • coordinates: 1089594..1090853
  • length: 1260
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NZ_AP018391 (1089594..1090853) NCBI
  • BioCyc:
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_0812 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    ATGAGTCGTTTACTAGTTATTGGTTGTGGGGGCGTTGCCCAAGTTGCTATTTCAAAAATT
    TGTCAAGATAGCGAAACATTTACAGAGATTATGATTGCTAGCCGTACCAAGTCAAAATGC
    GATGACTTGAAAGCGAAGCTAGAAGGCAAAACAAGTACTAAAATTGAAACTGCAGCACTT
    GATGCTGACAAGGTAGAAGAGGTCATTACCTTGATTGAAAGCTACAAACCAGAAGCTGTT
    TTGAATGTAGCTCTGCCTTATCAAGATTTAACCATTATGGATGCTTGTTTGGCAACAGGT
    GTTCACTATATCGATACAGCCAACTACGAAGCAGAAGACACAGAAGACCCTGAGTGGCGT
    GCTATCTACGAAAAACGTTGTAAGGAACTTGGTTTTACAGCCTACTTTGACTACTCATGG
    CAGTGGGCTTATCAAGAGAAATTCAAAGAAGCAGGCTTGACTGCTCTTCTTGGTTCTGGT
    TTTGACCCAGGTGTAACTAGTGTCTTTTCAGCTTATGCCCTCAAACACTATTTTGATGAA
    ATCCATTATATCGACATTTTAGACTGTAATGGCGGTGACCACGGTTATCCATTTGCAACC
    AACTTTAATCCAGAAATTAATCTCCGTGAGGTTTCTGCGCCAGGTTCTTACTGGGAAGAT
    GGGAAATGGGTCGAAGTCGAAGCTATGTCTATCAAGCGTGAGTATGATTTCCCTCAAGTT
    GGACAAAAAGATATGTATCTCCTTCACCATGAAGAAATCGAATCATTGGCCAAGAACATT
    CCAGGTGTCAAACGCATTCGTTTCTTTATGACTTTTGGTCAATCTTACTTGACGCACATG
    AAATGTCTTGAAAATGTTGGACTCCTTCGTACGGATACCATTAACTTTAACGGCCAAGAA
    ATTGTTCCAATTCAATTTTTGAAAGCCTTGCTTCCAGATCCTGCTAGCCTTGGCCCACGT
    ACTGTAGGTAAAACCAATATTGGATGTATCTTTACAGGTGTCAAAGATGGCGTTGAAAAG
    ACTATCTACATCTACAATGTTTGCGACCATCAAGAGTGCTATGCAGAAGTCGGGTCACAA
    GCAATTTCATACACGACAGGCGTTCCAGCCATGATTGGGACAAAATTAGTCATGAACGGA
    ACTTGGAAACAAGCTGGAGTGTATAACCTTGAGGAGTTAGATCCAGATCCATTCATGGAA
    GCTTTGAATGAGTATGGTTTGCCATGGGTTGTGGTTGAAAATCCACAAATGGTGGACTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: MDRSPN_RS05645 [old locus tag: MDRSPN_01074 ]
  • symbol: MDRSPN_RS05645
  • description: saccharopine dehydrogenase family protein
  • length: 419
  • theoretical pI: 4.41142
  • theoretical MW: 47021.1
  • GRAVY: -0.194988

⊟Function[edit | edit source]

  • reaction:
    EC 1.5.1.-?  ExPASy
  • TIGRFAM:
    Metabolism Amino acid biosynthesis Aromatic amino acid family shikimate dehydrogenase (TIGR00507; EC 1.1.1.25; HMM-score: 16.9)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Heme, porphyrin, and cobalamin glutamyl-tRNA reductase (TIGR01035; EC 1.2.1.70; HMM-score: 14.4)
    Metabolism Amino acid biosynthesis Glutamate family pyrroline-5-carboxylate reductase (TIGR00112; EC 1.5.1.2; HMM-score: 13.6)
    and 3 more
    Metabolism Central intermediary metabolism Other long-chain fatty acyl-ACP reductase (aldehyde-forming) (TIGR04058; EC 1.1.1.-; HMM-score: 12.8)
    Metabolism Amino acid biosynthesis Aromatic amino acid family shikimate-5-dehydrogenase (TIGR01809; EC 1.1.1.25; HMM-score: 12.7)
    Cellular processes Cellular processes Biosynthesis of natural products 2,3-diaminopropionate biosynthesis protein SbnB (TIGR03944; HMM-score: 12.3)
  • TheSEED: data available for D39, Hungary19A-6, TIGR4
  • PFAM:
    GADPH_aa-bio_dh (CL0139) Sacchrp_dh_C; Saccharopine dehydrogenase C-terminal domain (PF16653; HMM-score: 134)
    and 4 more
    NADP_Rossmann (CL0063) Sacchrp_dh_NADP; Saccharopine dehydrogenase NADP binding domain (PF03435; HMM-score: 103)
    Shikimate_DH; Shikimate / quinate 5-dehydrogenase (PF01488; HMM-score: 22.3)
    F420_oxidored; NADP oxidoreductase coenzyme F420-dependent (PF03807; HMM-score: 17.9)
    no clan defined NqrM; (Na+)-NQR maturation NqrM (PF04400; HMM-score: 12.1)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9426
    • Cytoplasmic Membrane Score: 0.0139
    • Cell wall & surface Score: 0.0001
    • Extracellular Score: 0.0434
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.096212
    • TAT(Tat/SPI): 0.003818
    • LIPO(Sec/SPII): 0.109676
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000088782 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MSRLLVIGCGGVAQVAISKICQDSETFTEIMIASRTKSKCDDLKAKLEGKTSTKIETAALDADKVEEVITLIESYKPEAVLNVALPYQDLTIMDACLATGVHYIDTANYEAEDTEDPEWRAIYEKRCKELGFTAYFDYSWQWAYQEKFKEAGLTALLGSGFDPGVTSVFSAYALKHYFDEIHYIDILDCNGGDHGYPFATNFNPEINLREVSAPGSYWEDGKWVEVEAMSIKREYDFPQVGQKDMYLLHHEEIESLAKNIPGVKRIRFFMTFGQSYLTHMKCLENVGLLRTDTINFNGQEIVPIQFLKALLPDPASLGPRTVGKTNIGCIFTGVKDGVEKTIYIYNVCDHQECYAEVGSQAISYTTGVPAMIGTKLVMNGTWKQAGVYNLEELDPDPFMEALNEYGLPWVVVENPQMVD

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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