PangenomeTIGR4

serotype 4

D39

serotype 2

D39V

serotype 2

Hungary19A-6

serotype 19A

EF3030

serotype 19F

670-6B

serotype 6B

6A-10

serotype 6A

70585

serotype 5

A026

serotype 19F

A66

serotype 3

AP200

serotype 11A

ASP0581

serotype 12F

ATCC 49619

serotype 19F

ATCC 700669

serotype 23F

BVJ1JL

serotype 1

CGSP14

serotype 14

G54

serotype 19F

HU-OH

serotype 3

Hu15

serotype 19A

Hu17

serotype 19A

INV104

serotype 1

INV200

serotype 14

JJA

serotype 14

MDRSPN001

serotype 19F

NCTC7466

serotype 2

NU83127

serotype 4

OXC141

serotype 3

P1031

serotype 1

R6

serotype 2

SP49

serotype 19A

SPN032672

serotype 1

SPN034156

serotype 3

SPN034183

serotype 3

SPN994038

serotype 3

SPN994039

serotype 3

SPNA45

serotype 3

ST556

serotype 19F

TCH8431/19A

serotype 19A

Taiwan19F-14

serotype 19F

Xen35

serotype 4

gamPNI0373

serotype 1

NCBI: 14-DEC-2020

⊟Summary

• organism: Streptococcus pneumoniae MDRSPN001
• locus tag: MDRSPN_RS05890 [old locus tag: MDRSPN_01117 ]
• pan locus tag^?: PNEUPAN001858000
• symbol: MDRSPN_RS05890
• pan gene symbol^?: fruR
• synonym:
• product: DeoR/GlpR family DNA-binding transcription regulator

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: MDRSPN_RS05890 [old locus tag: MDRSPN_01117 ]
• symbol: MDRSPN_RS05890
• product: DeoR/GlpR family DNA-binding transcription regulator
• replicon: chromosome
• strand: -
• coordinates: 1140939..1141679
• length: 741
• essential: unknown

⊟Accession numbers

• Location: NZ_AP018391 (1140939..1141679) NCBI
• BioCyc:
• MicrobesOnline:
• PneumoBrowse for strain D39V: SPV_0771 PneumoBrowse

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

• 1
  61
  121
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  301
  361
  421
  481
  541
  601
  661
  721
  
  GTGTTAAAAACAGAACGTAAACAACTAATTTTAGAGGAGTTAAATCAACATCATGTAGTT
  TCTCTAGAAAAATTAGTTAGTTTGCTAGAAACGTCAGAATCAACGGTTCGAAGAGACTTG
  GATGAGTTGGAAGCGGAAAACAAGCTTCGTCGTGTGCATGGTGGAGCAGAACTCCCCTAC
  TCCTTACAGGAAGAAGAAACCATTCAAGAAAAATCTGTCAAAAACCTTCAAGAAAAGAAA
  TTGCTGGCTCAGAAAGCAGCCTCTCTCATTAAAGAAAAAGATGTCATCTTTATCGATGCT
  GGAACAACAACTGCTTTTTTGATTCATGAATTGGTCAATAAGAATGTTACAGTTGTGACC
  AACTCCATTCACCATGCCGCTCAGTTGGTTGAAAAGCAGATTCCAACTGTCATGGTTGGA
  GGAAACGTCAAGACGGCGACAGATGCTAGTATCGGGGGCGTTGCTCTTAACCAGATTAAC
  CAATTGCACTTTGACCGTGCCTTTATCGGAATAAATGGTGTTGACGATGGCTATTATACG
  ACTCCTGATATGGAGGAGGGAGCTGTGAAAAGAGCTATTTTGGAGAATGCCAAGCAGACC
  TACGTCTTGGTGGATTCGTCAAAAATTGGACAAACTTGCTTTGCCAAGGTAGCCCCACTC
  AAACGCGCTATCGTTATCACTAGTCAAGGGCATGAGCTCTTGCAGGTTATTAAGGAGAAA
  ACGGAGGTAATAGAAGTATGA
  60
  120
  180
  240
  300
  360
  420
  480
  540
  600
  660
  720
  741
  

⊟Protein

⊟General

• locus tag: MDRSPN_RS05890 [old locus tag: MDRSPN_01117 ]
• symbol: MDRSPN_RS05890
• description: DeoR/GlpR family DNA-binding transcription regulator
• length: 246
• theoretical pI: 6.10609
• theoretical MW: 27285.1
• GRAVY: -0.193089

⊟Function

• TIGRFAM:
  Metabolism Energy metabolism Pentose phosphate pathway ribose 5-phosphate isomerase A (TIGR00021; EC 5.3.1.6; HMM-score: 19.6)
  and 1 more
  Signal transduction Regulatory functions DNA interactions CRISPR locus-related DNA-binding protein (TIGR01884; HMM-score: 8.9)
• TheSEED: data available for D39, Hungary19A-6, TIGR4
• PFAM:
  ISOCOT_Fold (CL0246) DeoRC; DeoR C terminal sensor domain (PF00455; HMM-score: 172.7)
  and 13 more
  HTH (CL0123) HTH_DeoR; DeoR-like helix-turn-helix domain (PF08220; HMM-score: 66.5)
  HTH_11; HTH domain (PF08279; HMM-score: 25.8)
  GntR; Bacterial regulatory proteins, gntR family (PF00392; HMM-score: 21.4)
  no clan defined DUF3972; Protein of unknown function (DUF3972) (PF13118; HMM-score: 18.6)
  HTH (CL0123) MarR; MarR family (PF01047; HMM-score: 16.4)
  Arg_repressor; Arginine repressor, DNA binding domain (PF01316; HMM-score: 16.4)
  NADP_Rossmann (CL0063) Shikimate_DH; Shikimate / quinate 5-dehydrogenase (PF01488; HMM-score: 16.2)
  no clan defined DUF2777; Protein of unknown function (DUF2777) (PF10949; HMM-score: 14.5)
  Toprim-like (CL0413) DUF3854; Domain of unknown function (DUF3854) (PF12965; HMM-score: 14.3)
  no clan defined FIMP; Fertilisation-influencing membrane protein (PF17672; HMM-score: 14)
  Nitro_FeMo-Co; Dinitrogenase iron-molybdenum cofactor (PF02579; HMM-score: 13.4)
  HTH (CL0123) DUF5805; Family of unknown function (DUF5805) (PF19121; HMM-score: 13)
  no clan defined Stk19; Serine-threonine protein kinase 19 (PF10494; HMM-score: 9.8)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:
• genes regulated by FruR*, TF important in Fructose utilization: in TIGR4

⊟Localization

• PSORTb: Cytoplasmic
  • Cytoplasmic Score: 7.5
  • Cytoplasmic Membrane Score: 1.15
  • Cellwall Score: 0.62
  • Extracellular Score: 0.73
  • Internal Helices: 0
• SignalP: no predicted signal peptide
  • SP(Sec/SPI): 0.003499
  • TAT(Tat/SPI): 0.000352
  • LIPO(Sec/SPII): 0.000253
• predicted transmembrane helices (TMHMM): 0

⊟Accession numbers

• GI:
• RefSeq: WP_000920667 NCBI
• UniProt:

⊟Protein sequence

• MLKTERKQLILEELNQHHVVSLEKLVSLLETSESTVRRDLDELEAENKLRRVHGGAELPYSLQEEETIQEKSVKNLQEKKLLAQKAASLIKEKDVIFIDAGTTTAFLIHELVNKNVTVVTNSIHHAAQLVEKQIPTVMVGGNVKTATDASIGGVALNQINQLHFDRAFIGINGVDDGYYTTPDMEEGAVKRAILENAKQTYVLVDSSKIGQTCFAKVAPLKRAIVITSQGHELLQVIKEKTEVIEV

⊟Experimental data

• protein localization:
• interaction partners:

⊟Expression & Regulation

⊟Operon

⊟Regulation

• data available for TIGR4

⊟Expression data

• PneumoExpress for strain D39V: SPV_0771 PneumoExpress

⊟Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊟Other Information

You are kindly invited to share additional interesting facts.

⊟Literature

⊟References

⊟Relevant publications