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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 10-NOV-2021

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae ST556
  • locus tag: MYY_RS05795 [old locus tag: MYY_1132 ]
  • pan locus tag?: PNEUPAN002230000
  • symbol: spxR
  • pan gene symbol?: spxR
  • synonym:
  • product: CBS-HotDog domain-containing transcription factor SpxR

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: MYY_RS05795 [old locus tag: MYY_1132 ]
  • symbol: spxR
  • product: CBS-HotDog domain-containing transcription factor SpxR
  • replicon: chromosome
  • strand: +
  • coordinates: 1103848..1105125
  • length: 1278
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NC_017769 (1103848..1105125) NCBI
  • BioCyc: MYY_RS05795 BioCyc
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_0969 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    ATGAGTAAGCATCAGGAAATTCTAAGCTATTTGGAGGAATTACCAGTAGGTAAAAGGGTC
    AGTGTTCGTAGCATTTCGAATCATCTAGGAGTTAGTGATGGAACAGCCTATCGGGCTATT
    AAAGAAGCTGAAAACCGTGGAATTGTGGAGACCCGTCCTAGAAGTGGAACAATTCGTGTT
    AAATCCCAGAAAGTTGCTATAGAGAGATTAACGTTTGCTGAAATTGCAGAAGTGACTTCT
    TCTGAGGTTCTGGCTGGGCAAGAAGGTTTAGAGAGAGAATTTAGTAAGTTTTCAATTGGT
    GCCATGACTGAACAAAATATCTTGTCTTACCTTCATGATGGGGGGCTCTTGATTGTCGGA
    GACCGAACCCGTATTCAGTTGCTAGCCTTGGAAAATGAAAATGCAGTTCTGGTTACAGGG
    GGATTTCAGGTTCATGATGATGTGCTTAAACTGGCCAATCAAAAAGGGATTCCTGTTCTA
    AGAAGTAAGCATGATACCTTTACCGTCGCGACCATGATCAATAAAGCCTTGTCAAATGTC
    CAAATCAAGACTGATATTCTGACAGTTGAGAAACTTTATCGCCCTAGTCATGAGTATGGT
    TTTCTGAGAGAGACAGATACAGTTAAAGATTATTTGGACTTGGTTCGTAAGAATCGTAGC
    AGCCGTTTCCCTGTTATCAATCAACATCAGGTCGTTGTTGGCGTTGTAACCATGAGAGAC
    GCTGGTGATAAATCACCAAGCACGACAATTGATAAGGTTATGTCTCGTAGTCTATTTTTG
    GTTGGATTATCGACAAATATTGCCAATGTGAGTCAACGGATGATCGCAGAAGACTTTGAA
    ATGGTACCAGTTGTTCGAAGCAATCAAACTTTGCTTGGCGTTGTGACGCGACGAGATGTC
    ATGGAGAAGATGAGCCGTTCCCAAGTTTCGGCTCTACCAACTTTTTCTGAGCAGATTGGA
    CAAAAGCTCTCTTATCACCATGATGAAGTAGTCATTACAGTGGAACCCTTTATGCTAGAA
    AAAAATGGAGTTTTGGCTAATGGTGTATTGGCAGAAATTCTGACCCACATGACCCAAGAT
    TTAGTTGTTAATAGTGGTCGCAATCTCATTATCGAGCAGATGCTAATCTACTTTTTGCAG
    GCTGTTCAGATAGATGATATATTGCGCATTCAGGCACGGATTATTCATCATACGAGACGG
    TCAGCTATAATTGATTACGATATTTATCATGGTCACCAGATTGTTTCAAAAGCAAATGTG
    ACTGTTAAAATTAATTAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1278

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: MYY_RS05795 [old locus tag: MYY_1132 ]
  • symbol: SpxR
  • description: CBS-HotDog domain-containing transcription factor SpxR
  • length: 425
  • theoretical pI: 8.68924
  • theoretical MW: 47649.5
  • GRAVY: -0.108941

⊟Function[edit | edit source]

  • TIGRFAM:
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Purine ribonucleotide biosynthesis inosine-5'-monophosphate dehydrogenase (TIGR01302; EC 1.1.1.205; HMM-score: 34.2)
    Metabolism Transport and binding proteins Cations and iron carrying compounds magnesium transporter (TIGR00400; HMM-score: 33.3)
    Metabolism Transport and binding proteins Amino acids, peptides and amines glycine betaine/L-proline transport ATP binding subunit (TIGR01186; HMM-score: 28)
    and 10 more
    Metabolism Amino acid biosynthesis Serine family cystathionine beta-synthase (TIGR01137; EC 4.2.1.22; HMM-score: 26.1)
    Signal transduction Regulatory functions DNA interactions CRISPR locus-related DNA-binding protein (TIGR01884; HMM-score: 23.3)
    tol-pal system-associated acyl-CoA thioesterase (TIGR02799; EC 3.1.2.-; HMM-score: 22.5)
    Signal transduction Regulatory functions Protein interactions HPr(Ser) kinase/phosphatase (TIGR00679; EC 2.7.1.-; HMM-score: 20)
    Signal transduction Signal transduction PTS HPr(Ser) kinase/phosphatase (TIGR00679; EC 2.7.1.-; HMM-score: 20)
    Unknown function General IMP dehydrogenase family protein (TIGR01303; HMM-score: 19.9)
    Unknown function General acyl-CoA thioester hydrolase, YbgC/YbaW family (TIGR00051; HMM-score: 18.4)
    phenylacetic acid degradation protein PaaD (TIGR02286; HMM-score: 14.7)
    Metabolism Energy metabolism Amino acids and amines histidine utilization repressor (TIGR02018; HMM-score: 12.2)
    Signal transduction Regulatory functions DNA interactions histidine utilization repressor (TIGR02018; HMM-score: 12.2)
  • TheSEED: see MYY_1132
  • PFAM:
    MurF-HprK_N (CL0365) DRTGG; DRTGG domain (PF07085; HMM-score: 105.5)
    and 20 more
    no clan defined CBS; CBS domain (PF00571; HMM-score: 47.8)
    HTH (CL0123) HTH_24; Winged helix-turn-helix DNA-binding (PF13412; HMM-score: 26)
    GntR; Bacterial regulatory proteins, gntR family (PF00392; HMM-score: 25.2)
    HTH_28; Helix-turn-helix domain (PF13518; HMM-score: 22.8)
    HotDog (CL0050) 4HBT; Thioesterase superfamily (PF03061; HMM-score: 22.7)
    MurF-HprK_N (CL0365) Hpr_kinase_N; HPr Serine kinase N terminus (PF02603; HMM-score: 20.8)
    HTH (CL0123) HTH_36; Helix-turn-helix domain (PF13730; HMM-score: 20)
    no clan defined PucR; Purine catabolism regulatory protein-like family (PF07905; HMM-score: 19.6)
    HTH (CL0123) HTH_11; HTH domain (PF08279; HMM-score: 18.8)
    MarR_2; MarR family (PF12802; HMM-score: 18.8)
    HTH_Crp_2; Crp-like helix-turn-helix domain (PF13545; HMM-score: 18.8)
    TrmB; Sugar-specific transcriptional regulator TrmB (PF01978; HMM-score: 18.7)
    HTH_29; Winged helix-turn helix (PF13551; HMM-score: 17.7)
    HTH_DeoR; DeoR-like helix-turn-helix domain (PF08220; HMM-score: 16.7)
    HTH_10; HTH DNA binding domain (PF04967; HMM-score: 14.1)
    HTH_Tnp_ISL3; Helix-turn-helix domain of transposase family ISL3 (PF13542; HMM-score: 13.7)
    Fe_dep_repress; Iron dependent repressor, N-terminal DNA binding domain (PF01325; HMM-score: 13)
    HTH_5; Bacterial regulatory protein, arsR family (PF01022; HMM-score: 12.8)
    HTH_23; Homeodomain-like domain (PF13384; HMM-score: 12.5)
    HTH_IclR; IclR helix-turn-helix domain (PF09339; HMM-score: 12.1)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.004741
    • TAT(Tat/SPI): 0.001173
    • LIPO(Sec/SPII): 0.000707
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000033830 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MSKHQEILSYLEELPVGKRVSVRSISNHLGVSDGTAYRAIKEAENRGIVETRPRSGTIRVKSQKVAIERLTFAEIAEVTSSEVLAGQEGLEREFSKFSIGAMTEQNILSYLHDGGLLIVGDRTRIQLLALENENAVLVTGGFQVHDDVLKLANQKGIPVLRSKHDTFTVATMINKALSNVQIKTDILTVEKLYRPSHEYGFLRETDTVKDYLDLVRKNRSSRFPVINQHQVVVGVVTMRDAGDKSPSTTIDKVMSRSLFLVGLSTNIANVSQRMIAEDFEMVPVVRSNQTLLGVVTRRDVMEKMSRSQVSALPTFSEQIGQKLSYHHDEVVITVEPFMLEKNGVLANGVLAEILTHMTQDLVVNSGRNLIIEQMLIYFLQAVQIDDILRIQARIIHHTRRSAIIDYDIYHGHQIVSKANVTVKIN

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

Smirla Ramos-Montañez, Ho-Ching Tiffany Tsui, Kyle J Wayne, Jordan L Morris, Lindsey E Peters, Faming Zhang, Krystyna M Kazmierczak, Lok-To Sham, Malcolm E Winkler
Polymorphism and regulation of the spxB (pyruvate oxidase) virulence factor gene by a CBS-HotDog domain protein (SpxR) in serotype 2 Streptococcus pneumoniae.
Mol Microbiol: 2008, 67(4);729-46
[PubMed:18179423] [WorldCat.org] [DOI] (P p)

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