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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 02-APR-2025

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae ST556
  • locus tag: MYY_RS07280 [old locus tag: MYY_1414 ]
  • pan locus tag?: PNEUPAN001721000
  • symbol: trmD
  • pan gene symbol?: trmD
  • synonym:
  • product: tRNA (guanosine(37)-N1)-methyltransferase TrmD

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: MYY_RS07280 [old locus tag: MYY_1414 ]
  • symbol: trmD
  • product: tRNA (guanosine(37)-N1)-methyltransferase TrmD
  • replicon: chromosome
  • strand: -
  • coordinates: 1392073..1392792
  • length: 720
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

  • Location: NC_017769 (1392073..1392792) NCBI
  • BioCyc: MYY_RS07280 BioCyc
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_0679 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    ATGAAGATTGATATTTTAACCCTCTTTCCAGAGATGTTTTCTCCACTGGAGCACTCAATC
    GTTGGAAAGGCTCGAGAAAAAGGGCTCTTGGATATCCAGTATCATAATTTTCGAGAAAAT
    GCTGAAAAGGCCCGTCATGTAGATGATGAGCCCTACGGAGGCGGTCAGGGCATGTTGCTC
    AGAGCACAACCTATTTTCGATTCCTTTGATGCTATTGAAAAGAAAAATCCGCGCGTTATT
    CTCCTCGATCCTGCTGGAAAGCAGTTTGATCAGGCTTATGCTGAAGATTTGGCTCAAGAG
    GAAGAGCTAATCTTTATCTGTGGGCACTATGAGGGTTATGATGAGCGCATTAAGACCTTG
    GTAACAGATGAGATTTCCCTAGGCGACTATGTCCTCACTGGTGGAGAATTGGCAGCTATG
    ACCATGATTGATGCTACAGTTCGCCTGATTCCAGAAGTGATTGGCAAGGAGTCTAGCCAC
    CAAGATGATAGTTTTTCTTCAGGTCTTTTAGAATATCCTCAGTACACACGTCCCTATGAT
    TATCGAGGCATGGTCGTGCCAGATGTATTGATGAGTGGCCACCATGAAAAGATTCGTCAG
    TGGCGATTGTACGAGAGTTTAAAGAAAACCTACGAGCGCAGACCAGATTTACTTGAACAT
    TATCAACTGACAGTAGAAGAAGAAAAAATGCTGGCAGAAATCAAAGAAAACAAAGAATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: MYY_RS07280 [old locus tag: MYY_1414 ]
  • symbol: TrmD
  • description: tRNA (guanosine(37)-N1)-methyltransferase TrmD
  • length: 239
  • theoretical pI: 4.5841
  • theoretical MW: 27633.1
  • GRAVY: -0.555649

⊟Function[edit | edit source]

  • reaction:
    EC 2.1.1.228?  ExPASy
    tRNA (guanine37-N1)-methyltransferase S-adenosyl-L-methionine + guanine37 in tRNA = S-adenosyl-L-homocysteine + N1-methylguanine37 in tRNA
  • TIGRFAM:
    Genetic information processing Protein synthesis tRNA and rRNA base modification tRNA (guanine(37)-N(1))-methyltransferase (TIGR00088; EC 2.1.1.228; HMM-score: 304.4)
  • TheSEED: see MYY_1414
  • PFAM:
    SPOUT (CL0098) tRNA_m1G_MT; tRNA (Guanine-1)-methyltransferase (PF01746; HMM-score: 219.1)
    and 2 more
    SPOUT_MTase; Predicted SPOUT methyltransferase (PF02590; HMM-score: 17.8)
    no clan defined DUF2573; Protein of unknown function (DUF2573) (PF10835; HMM-score: 14)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9993
    • Cytoplasmic Membrane Score: 0.0002
    • Cell wall & surface Score: 0
    • Extracellular Score: 0.0006
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.010634
    • TAT(Tat/SPI): 0.00031
    • LIPO(Sec/SPII): 0.000676
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000686921 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MKIDILTLFPEMFSPLEHSIVGKAREKGLLDIQYHNFRENAEKARHVDDEPYGGGQGMLLRAQPIFDSFDAIEKKNPRVILLDPAGKQFDQAYAEDLAQEEELIFICGHYEGYDERIKTLVTDEISLGDYVLTGGELAAMTMIDATVRLIPEVIGKESSHQDDSFSSGLLEYPQYTRPYDYRGMVVPDVLMSGHHEKIRQWRLYESLKKTYERRPDLLEHYQLTVEEEKMLAEIKENKE

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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