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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 17-JUN-2018

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae NCTC7466
  • locus tag: NCTC7466_00250 [new locus tag: DQM66_RS01325 ]
  • pan locus tag?: PNEUPAN000996000
  • symbol: uppS
  • pan gene symbol?: uppS
  • synonym:
  • product: undecaprenyl pyrophosphate synthase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: NCTC7466_00250 [new locus tag: DQM66_RS01325 ]
  • symbol: uppS
  • product: undecaprenyl pyrophosphate synthase
  • replicon: chromosome
  • strand: +
  • coordinates: 234367..235125
  • length: 759
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

  • Location: LS483374 (234367..235125) NCBI
  • BioCyc:
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_0243 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    ATGTTTGGATTTTTTAAGAAAGATAAGGCTGTGGAAGTAGAGGTTCCGACACAGGTTCCT
    GCTCATATCGGCATCATCATGGATGGCAATGGCCGTTGGGCTAAAAAACGTATGCAACCG
    CGAGTTTTTGGACACAAGGCGGGCATGGAAGCATTGCAAACCGTGACCAAGGCAGCCAAC
    AAACTGGGCGTCAAGGTTATTACGGTCTATGCTTTTTCTACGGAAAACTGGACCCGTCCA
    GATCAGGAAGTCAAGTTTATCATGAACTTGCCAGTAGAGTTTTATGATAATTATGTCCCG
    GAACTACATGCGAATAATGTTAAGATTCAAATGATTGGGGAGACAGACCGCCTGCCTAAG
    CAAACCTTTGAAGCTTTAACCAAGGCTGAGGAATTGACTAAGAACAACACAGGATTGATT
    CTTAATTTTGCTCTTAACTATGGTGGACGTGCTGAGATTACACAGGCGCTTAAGTTGATT
    TCCCAGGATGTTTTAGATGCCAAAATCAACCCAGGTGACATCACAGAGGAATTGATTGGT
    AACTATCTCTTTACTCAGCATTTGCCTAAGGACTTACGAGACCCAGACTTGATTATCCGT
    ACTAGTGGAGAATTACGTTTGAGCAATTTCCTTCCATGGCAGGGAGCCTATAGTGAGCTT
    TATTTTACGGACACCTTATGGCCTGATTTTGACGAAGCGGCCTTGCAGGAAGCTATTCTT
    GCCTATAATCGTCGTCATCGCCGATTTGGAGGAGTTTAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    759

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: NCTC7466_00250 [new locus tag: DQM66_RS01325 ]
  • symbol: UppS
  • description: undecaprenyl pyrophosphate synthase
  • length: 252
  • theoretical pI: 6.69499
  • theoretical MW: 28704.7
  • GRAVY: -0.329762

⊟Function[edit | edit source]

  • reaction:
    EC 2.5.1.31?  ExPASy
    Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) (2E,6E)-farnesyl diphosphate + 8 isopentenyl diphosphate = 8 diphosphate + di-trans,octa-cis-undecaprenyl diphosphate
  • TIGRFAM:
    Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides di-trans,poly-cis-decaprenylcistransferase (TIGR00055; EC 2.5.1.31; HMM-score: 280.4)
  • TheSEED: data available for D39, Hungary19A-6, TIGR4
  • PFAM:
    no clan defined Prenyltransf; Putative undecaprenyl diphosphate synthase (PF01255; HMM-score: 263.3)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9653
    • Cytoplasmic Membrane Score: 0.0254
    • Cell wall & surface Score: 0
    • Extracellular Score: 0.0093
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.008127
    • TAT(Tat/SPI): 0.000878
    • LIPO(Sec/SPII): 0.000786
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: SQG01309 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MFGFFKKDKAVEVEVPTQVPAHIGIIMDGNGRWAKKRMQPRVFGHKAGMEALQTVTKAANKLGVKVITVYAFSTENWTRPDQEVKFIMNLPVEFYDNYVPELHANNVKIQMIGETDRLPKQTFEALTKAEELTKNNTGLILNFALNYGGRAEITQALKLISQDVLDAKINPGDITEELIGNYLFTQHLPKDLRDPDLIIRTSGELRLSNFLPWQGAYSELYFTDTLWPDFDEAALQEAILAYNRRHRRFGGV

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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