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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 17-JUN-2018

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae NCTC7466
  • locus tag: NCTC7466_01801 [new locus tag: DQM66_RS09375 ]
  • pan locus tag?: PNEUPAN003581000
  • symbol: endA
  • pan gene symbol?: endA
  • synonym:
  • product: DNA-entry nuclease (competence-specific nuclease)

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: NCTC7466_01801 [new locus tag: DQM66_RS09375 ]
  • symbol: endA
  • product: DNA-entry nuclease (competence-specific nuclease)
  • replicon: chromosome
  • strand: -
  • coordinates: 1761866..1762690
  • length: 825
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: LS483374 (1761866..1762690) NCBI
  • BioCyc:
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_1762 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    ATGAACAAAAAAACAAGACAGACACTAATCGGACTGCTAGTGTTATTGCTTTTGTCTACA
    GGGAGCTATTATATCAAGCAGATGCCGTCGGCACCTAATAGTCCCAAAACCAATCTTAGT
    CAGAAAAAACAAGCGTCTGAAGCTCCTAGTCAAGCATTGGCAGAGAGTGTCTTAACAGAC
    GCAGTCAAGAGTCAAATAAAGGGGAGTCTGGAGTGGAATGGCTCAGGTGCTTTTATCGTC
    AATGGTAATAAAACAAATCTAGATGCCAAGGTTTCAAGTAAGCCCTACGCTGACAATAAA
    ACAAAGACAGTGGGCAAGGAAACTGTTCCAACCGTAGCTAATGCCCTCTTGTCTAAGGCC
    ACTCGTCAGTACAAGAATCGTAAAGAAACTGGGAATGGTTCAACTTCTTGGACTCCTCCA
    GGTTGGCATCAGGTCAAGAATCTAAAGGGCTCTTATACCCATGCAGTCGATAGAGGTCAT
    TTGTTAGGCTATGCCTTAATCGGTGGTTTGGATGGTTTTGATGCCTCAACAAGCAATCCT
    AAAAACATTGCTGTTCAGACAGCCTGGGCAAATCAGGCACAAGCCGAGTATTCGACTGGT
    CAAAACTACTATGAAAGCAAGGTGCGTAAAGCCTTGGACCAAAACAAGCGTGTCCGTTAC
    CGTGTAACCCTTTACTACGCTTCAAACGAGGATTTAGTTCCCTCAGCTTCACAGATTGAA
    GCCAAGTCTTCGGATGGAGAATTGGAATTCAATGTTCTAGTTCCCAATGTTCAAAAGGGA
    CTTCAACTGGATTACCGAACTGGAGAAGTAACTGTAACTCAGTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    825

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: NCTC7466_01801 [new locus tag: DQM66_RS09375 ]
  • symbol: EndA
  • description: DNA-entry nuclease (competence-specific nuclease)
  • length: 274
  • theoretical pI: 10.1214
  • theoretical MW: 29890.3
  • GRAVY: -0.608394

⊟Function[edit | edit source]

  • reaction:
    EC 3.1.30.-?  ExPASy
  • TIGRFAM:
  • TheSEED: data available for D39, Hungary19A-6, TIGR4
  • PFAM:
    His-Me_finger (CL0263) Endonuclease_NS; DNA/RNA non-specific endonuclease (PF01223; HMM-score: 70.7)
    and 2 more
    Endonuclea_NS_2; DNA/RNA non-specific endonuclease (PF13930; HMM-score: 43.3)
    SDH_beta (CL0697) SDH_beta; Serine dehydratase beta chain (PF03315; HMM-score: 12.7)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 10
    • Cellwall Score: 0
    • Extracellular Score: 0
    • Internal Helix: 1
  • DeepLocPro: Cytoplasmic Membrane
    • Cytoplasmic Score: 0.0015
    • Cytoplasmic Membrane Score: 0.6258
    • Cell wall & surface Score: 0.0012
    • Extracellular Score: 0.3714
  • SignalP: Signal peptide LIPO(Sec/SPII) length 21 aa
    • SP(Sec/SPI): 0.356297
    • TAT(Tat/SPI): 0.017166
    • LIPO(Sec/SPII): 0.421319
    • Cleavage Site: CS pos: 21-22. STG-SY. Pr: 0.2763
  • predicted transmembrane helices (TMHMM): 1

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: SQG02800 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MNKKTRQTLIGLLVLLLLSTGSYYIKQMPSAPNSPKTNLSQKKQASEAPSQALAESVLTDAVKSQIKGSLEWNGSGAFIVNGNKTNLDAKVSSKPYADNKTKTVGKETVPTVANALLSKATRQYKNRKETGNGSTSWTPPGWHQVKNLKGSYTHAVDRGHLLGYALIGGLDGFDASTSNPKNIAVQTAWANQAQAEYSTGQNYYESKVRKALDQNKRVRYRVTLYYASNEDLVPSASQIEAKSSDGELEFNVLVPNVQKGLQLDYRTGEVTVTQ

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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