PangenomeTIGR4

serotype 4

D39

serotype 2

D39V

serotype 2

Hungary19A-6

serotype 19A

EF3030

serotype 19F

670-6B

serotype 6B

6A-10

serotype 6A

70585

serotype 5

A026

serotype 19F

A66

serotype 3

AP200

serotype 11A

ASP0581

serotype 12F

ATCC 49619

serotype 19F

ATCC 700669

serotype 23F

BM6001

serotype 19F

BVJ1JL

serotype 1

CGSP14

serotype 14

G54

serotype 19F

HU-OH

serotype 3

Hu15

serotype 19A

Hu17

serotype 19A

INV104

serotype 1

INV200

serotype 14

JJA

serotype 14

MDRSPN001

serotype 19F

NCTC7465

serotype 1

NCTC7466

serotype 2

NU83127

serotype 4

OXC141

serotype 3

P1031

serotype 1

R6

serotype 2

SP49

serotype 19A

SPN032672

serotype 1

SPN034156

serotype 3

SPN034183

serotype 3

SPN994038

serotype 3

SPN994039

serotype 3

SPNA45

serotype 3

ST556

serotype 19F

TCH8431/19A

serotype 19A

Taiwan19F-14

serotype 19F

Xen35

serotype 4

gamPNI0373

serotype 1

NCBI: 08-SEP-2024

⊟Summary

• organism: Streptococcus pneumoniae BM6001
• locus tag: ODS73_RS08245 [old locus tag: ODS73_08235 ]
• pan locus tag^?: PNEUPAN002873000
• symbol: ODS73_RS08245
• pan gene symbol^?: —
• synonym:
• product: helix-turn-helix transcriptional regulator

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: ODS73_RS08245 [old locus tag: ODS73_08235 ]
• symbol: ODS73_RS08245
• product: helix-turn-helix transcriptional regulator
• replicon: chromosome
• strand: -
• coordinates: 1594090..1594305
• length: 216
• essential: unknown

⊟Accession numbers

• Location: NZ_CP107038 (1594090..1594305) NCBI
• BioCyc:
• MicrobesOnline:
• PneumoBrowse for strain D39V:

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

• 1
  61
  121
  181
  
  GTGCAGTGGACTTTAGAAGCTATGAGAATCAACAAAGGACTTACTCAAGCAGAGTTGGCA
  GAAAAATTTGAAGTTTCAAGTCAAACAATTGCTAGATTAGAAAAAGATAGCTCTGATATC
  GGTTATCAGCTATTGAAAAAATACATGTTTTTTTTCAATGTGAAATTCGATGATATTTTT
  TTAGGGAAAAAATACGAAAATTTCGTAAATAACTAG
  60
  120
  180
  216
  

⊟Protein

⊟General

• locus tag: ODS73_RS08245 [old locus tag: ODS73_08235 ]
• symbol: ODS73_RS08245
• description: helix-turn-helix transcriptional regulator
• length: 71
• theoretical pI: 6.79625
• theoretical MW: 8422.62
• GRAVY: -0.398592

⊟Function

• TIGRFAM:
  Signal transduction Regulatory functions DNA interactions transcriptional regulator, y4mF family (TIGR03070; HMM-score: 34.2)
  and 9 more
  putative zinc finger/helix-turn-helix protein, YgiT family (TIGR03830; HMM-score: 18.5)
  RNA polymerase sigma factor, sigma-70 family (TIGR02937; HMM-score: 14.1)
  Unknown function General mobile mystery protein A (TIGR02612; HMM-score: 13.9)
  Genetic information processing Mobile and extrachromosomal element functions Other addiction module antidote protein, HigA family (TIGR02607; HMM-score: 12.8)
  Signal transduction Regulatory functions DNA interactions addiction module antidote protein, HigA family (TIGR02607; HMM-score: 12.8)
  Signal transduction Regulatory functions Protein interactions addiction module antidote protein, HigA family (TIGR02607; HMM-score: 12.8)
  Cellular processes Cellular processes Sporulation and germination RNA polymerase sigma-G factor (TIGR02850; HMM-score: 12.4)
  Genetic information processing Transcription Transcription factors RNA polymerase sigma-G factor (TIGR02850; HMM-score: 12.4)
  Hypothetical proteins Conserved TIGR00270 family protein (TIGR00270; HMM-score: 11.9)
• TheSEED:
• PFAM:
  HTH (CL0123) HTH_3; Helix-turn-helix (PF01381; HMM-score: 40.4)
  HTH_19; Helix-turn-helix domain (PF12844; HMM-score: 32.4)
  and 18 more
  HTH_31; Helix-turn-helix domain (PF13560; HMM-score: 24.8)
  HTH_26; Cro/C1-type HTH DNA-binding domain (PF13443; HMM-score: 22.7)
  Sigma70_r4; Sigma-70, region 4 (PF04545; HMM-score: 20.3)
  HTH_11; HTH domain (PF08279; HMM-score: 19.5)
  MarR_2; MarR family (PF12802; HMM-score: 19.3)
  HTH_25; Helix-turn-helix domain (PF13413; HMM-score: 19)
  HTH_28; Helix-turn-helix domain (PF13518; HMM-score: 18.2)
  HTH_24; Winged helix-turn-helix DNA-binding (PF13412; HMM-score: 16.5)
  HTH_38; Helix-turn-helix domain (PF13936; HMM-score: 14.4)
  HTH_psq; helix-turn-helix, Psq domain (PF05225; HMM-score: 14.2)
  Sigma70_ECF; ECF sigma factor (PF07638; HMM-score: 14.2)
  Trp_repressor; Trp repressor protein (PF01371; HMM-score: 13.3)
  HTH_23; Homeodomain-like domain (PF13384; HMM-score: 13.2)
  Sigma70_r4_2; Sigma-70, region 4 (PF08281; HMM-score: 13.1)
  MarR; MarR family (PF01047; HMM-score: 12.6)
  HTH_37; Helix-turn-helix domain (PF13744; HMM-score: 12.5)
  GntR; Bacterial regulatory proteins, gntR family (PF00392; HMM-score: 12.1)
  HTH_Tnp_4; Helix-turn-helix of DDE superfamily endonuclease (PF13613; HMM-score: 12)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• PSORTb: unknown (no significant prediction)
  • Cytoplasmic Score: 2.5
  • Cytoplasmic Membrane Score: 2.5
  • Cellwall Score: 2.5
  • Extracellular Score: 2.5
  • Internal Helices: 0
• DeepLocPro: Cytoplasmic
  • Cytoplasmic Score: 0.8546
  • Cytoplasmic Membrane Score: 0.0911
  • Cell wall & surface Score: 0.0002
  • Extracellular Score: 0.054
• SignalP: no predicted signal peptide
  • SP(Sec/SPI): 0.003678
  • TAT(Tat/SPI): 0.000333
  • LIPO(Sec/SPII): 0.00074
• predicted transmembrane helices (TMHMM): 0

⊟Accession numbers

• GI:
• RefSeq: WP_001198773 NCBI
• UniProt:

⊟Protein sequence

• MQWTLEAMRINKGLTQAELAEKFEVSSQTIARLEKDSSDIGYQLLKKYMFFFNVKFDDIFLGKKYENFVNN

⊟Experimental data

• protein localization:
• interaction partners:

⊟Expression & Regulation

⊟Operon

⊟Regulation

• regulator:

⊟Transcription

• transcription start site:

⊟Expression data

• PneumoExpress for strain D39V:

⊟Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊟Other Information

You can add further information about the gene and protein here. [edit]

⊟Literature

⊟References

⊟Relevant publications