PangenomeTIGR4

serotype 4

D39

serotype 2

D39V

serotype 2

Hungary19A-6

serotype 19A

EF3030

serotype 19F

670-6B

serotype 6B

6A-10

serotype 6A

70585

serotype 5

A026

serotype 19F

A66

serotype 3

AP200

serotype 11A

ASP0581

serotype 12F

ATCC 49619

serotype 19F

ATCC 700669

serotype 23F

BM6001

serotype 19F

BVJ1JL

serotype 1

CGSP14

serotype 14

G54

serotype 19F

HU-OH

serotype 3

Hu15

serotype 19A

Hu17

serotype 19A

INV104

serotype 1

INV200

serotype 14

JJA

serotype 14

MDRSPN001

serotype 19F

NCTC7465

serotype 1

NCTC7466

serotype 2

NU83127

serotype 4

OXC141

serotype 3

P1031

serotype 1

R6

serotype 2

SP49

serotype 19A

SPN032672

serotype 1

SPN034156

serotype 3

SPN034183

serotype 3

SPN994038

serotype 3

SPN994039

serotype 3

SPNA45

serotype 3

ST556

serotype 19F

TCH8431/19A

serotype 19A

Taiwan19F-14

serotype 19F

Xen35

serotype 4

gamPNI0373

serotype 1

⊟Summary

• pan ID^?: PNEUPAN001203000
• symbol^?: pbp1a
• synonym:
• description^?: penicillin-binding protein PBP1A

  descriptions from strain specific annotations:

  • penicillin-binding protein PBP1A
  • penicillin-binding protein 1A
  • putative penicillin-binding protein 1A
  • penicillin-binding protein
  • Membrane carboxypeptidase (penicillin-binding protein)
  • Multimodular transpeptidase-transglycosylase, penicillin-binding protein 1A
  • Multimodular transpeptidase-transglycosylase / Penicillin-binding protein 1A/1B (PBP1)
  • penicillin-binding protein, 1A family
• strand^?: -
• coordinates^?: 1502252..1504447
• occurrence^?: in 100% of 43 strains

⊟Orthologs

(4)^?
TIGR4:
SP_RS01800 (pbp1a)
(2)
D39:
SPD_RS01830 (pbp1a)
(2)
D39V:
SPV_RS01830 (pbp1a)
(19A)
Hungary19A-6:
SPH_RS02315 (pbp1a)
(19F)
EF3030:
EF3030_RS01785 (pbp1a)
(6B)^?
670-6B:
SP670_RS02195 (pbp1a)
(6A)
6A-10:
HKM25_RS01905 (pbp1a)
(5)
70585:
SP70585_RS02155 (pbp1a)
(19F)
A026:
T308_RS01820 (pbp1a)
(3)
A66:
A66_RS01760 (pbp1a)
(11A)
AP200:
SPAP_RS01940 (pbp1a)
(12F)
ASP0581:
EL334_RS02005 (pbp1a)
(19F)
ATCC 49619:
EL263_RS02010 (pbp1a)
(23F)
ATCC 700669:
SPN23F_RS01755 (pbp1a)
(19F)
BM6001:
ODS73_RS02265 (pbp1a)
(1)
BVJ1JL:
JN057_RS01990 (pbp1a)
(14)
CGSP14:
SPCG_RS01905 (pbp1a)
(19F)
G54:
SPG_RS01695 (pbp1a)
(1)
gamPNI0373:
HMPREF1038_RS02070 (pbp1a)
(3)
HU-OH:
EL271_RS01775 (pbp1a)
(19A)
Hu15:
SPNHU15_RS02080 (pbp1a)
(19A)
Hu17:
SPNHU17_RS02010 (pbp1a)
(1)
INV104:
INV104_RS01850 (pbp1a)
(14)
INV200:
SPNINV200_RS01760 (pbp1a)
(14)
JJA:
SPJ_RS01795 (pbp1a)
(19F)
MDRSPN001:
MDRSPN_RS01780 (pbp1a)
(1)
NCTC7465:
AT689_RS00640 (pbp1a)
(2)
NCTC7466:
DQM66_RS01830 (pbp1a)
(4)
NU83127:
EL277_RS01905 (pbp1a)
(3)
OXC141:
SPNOXC_RS01980 (pbp1a)
(1)
P1031:
SPP_RS02020 (pbp1a)
(2)
R6:
SPR_RS01705 (pbp1a)
(19A)
SP49:
BMJ42_RS02485 (pbp1a)
(1)
SPN032672:
SPN032672_RS08150 (pbp1a)
(3)
SPN034156:
SPN034156_RS07905 (pbp1a)
(3)
SPN034183:
SPN034183_RS01990 (pbp1a)
(3)
SPN994038:
SPN994038_RS01915 (pbp1a)
(3)
SPN994039:
SPN994039_RS01910 (pbp1a)
(3)
SPNA45:
SPNA45_RS09410 (pbp1a)
(19F)
ST556:
MYY_RS02290 (pbp1a)
(19F)
Taiwan19F-14:
SPT_RS02080 (pbp1a)
(19A)
TCH8431/19A:
HMPREF0837_RS03245 (pbp1a)
(4)
Xen35:
CXP32_RS01860 (pbp1a)

⊟Genome Viewer

TIGR4
D39
D39V
Hungary19A-6
EF3030

⊟Alignments

• alignment of orthologues:
  CLUSTAL format alignment by MAFFT L-INS-i (v7.505)
  
  
  TIGR4           MNKPTILRLIKYLSISFLSLVIAAIVLGGGVFFYYVSKAPSLSESKLVATTSSKIYDNKN
  D39             MNKPTILRLIKYLSISFLSLVIAAIVLGGGVFFYYVSKAPSLSESKLVATTSSKIYDNKN
  D39V            MNKPTILRLIKYLSISFLSLVIAAIVLGGGVFFYYVSKAPSLSESKLVATTSSKIYDNKN
  Hungary19A-6    MNKQTILRIAKYVSICFLTLFITAVMLGGGIFLYYVSKAPALSESKLVATTSSKIFDSKN
  EF3030          MNKPTILRLIKYLSISFLSLVIAAIVLGGGVFFYYVSKAPSLSESKLVATTSSKIYDNKN
                  *** ****: **:**.**:*.*:*::****:*:*******:**************:*.**
  
  TIGR4           QLIADLGSERRVNAQANDIPTDLVKAIVSIEDHRFFDHRGIDTIRILGAFLRNLQSNSLQ
  D39             QLIADLGSERRVNAQANDIPTDLVKAIVSIEDHRFFDHRGIDTIRILGAFLRNLQSNSLQ
  D39V            QLIADLGSERRVNAQANDIPTDLVKAIVSIEDHRFFDHRGIDTIRILGAFLRNLQSNSLQ
  Hungary19A-6    ELIADLGSERRVNAQANEIPTDLVKAIVSIEDHRFFDHRGVDTIRIIGAFLRNLQNNSLQ
  EF3030          QLIADLGSERRVNAQANDIPTDLVKAIVSIEDHRFFDHRGIDTIRILGAFLRNLQSNSLQ
                  :****************:**********************:*****:********.****
  
  TIGR4           GGSTLTQQLIKLTYFSTSTSDQTISRKAQEAWLAIQLEQKATKQEILTYYINKVYMSNGN
  D39             GGSTLTQQLIKLTYFSTSTSDQTISRKAQEAWLAIQLEQKATKQEILTYYINKVYMSNGN
  D39V            GGSTLTQQLIKLTYFSTSTSDQTISRKAQEAWLAIQLEQKATKQEILTYYINKVYMSNGN
  Hungary19A-6    GGSTLTQQLIKLTYFSTSTSDQTISRKAQEAWLAVQLEQKTTKQEILTYYVNKVYMSNGN
  EF3030          GGSTLTQQLIKLTYFSTSTSDQTISRKAQEAWLAIQLEQKATKQEILTYYINKVYMSNGN
                  **********************************:*****:*********:*********
  
  TIGR4           YGMQTAAQNYYGKDLNNLSLPQLALLAGMPQAPNQYDPYSHPEAAQDRRNLVLSEMKNQG
  D39             YGMQTAAQNYYGKDLNNLSLPQLALLAGMPQAPNQYDPYSHPEAAQDRRNLVLSEMKNQG
  D39V            YGMQTAAQNYYGKDLNNLSLPQLALLAGMPQAPNQYDPYSHPEAAQDRRNLVLSEMKNQG
  Hungary19A-6    YGMQTAAQNYYGKDLRELSLPQLALLAGMPQAPNQYDPYSHPEAALDRRNLVLSEMKGQG
  EF3030          YGMQTAAQNYYGKDLNNLSLPQLALLAGMPQAPNQYDPYSHPEAAQDRRNLVLSEMKNQG
                  ***************.:**************************** ***********.**
  
  TIGR4           YISAEQYEKAVNTPITDGLQSLKSASNYPAYMDNYLKEVINQVEEETGYNLLTTGMDVYT
  D39             YISAEQYEKAVNTPITDGLQSLKSASNYPAYMDNYLKEVINQVEEETGYNLLTTGMDVYT
  D39V            YISAEQYEKAVNTPITDGLQSLKSASNYPAYMDNYLKEVINQVEEETGYNLLTTGMDVYT
  Hungary19A-6    YISAEQYEKAINTPITDGLQSLKSVNSYPAYMDNYLKEVIDQVEQETGYNLLTTGMDVYT
  EF3030          YISAEQYEKAVNTPITDGLQSLKSASNYPAYMDNYLKEVINQVEEETGYNLLTTGMDVYT
                  **********:*************...*************:***:***************
  
  TIGR4           NVDQEAQKHLWDIYNTDEYVAYPDDELQVASTIVDVSNGKVIAQLGARHQSSNVSFGINQ
  D39             NVDQEAQKHLWDIYNTDEYVAYPDDELQVASTIVDVSNGKVIAQLGARHQSSNVSFGINQ
  D39V            NVDQEAQKHLWDIYNTDEYVAYPDDELQVASTIVDVSNGKVIAQLGARHQSSNVSFGINQ
  Hungary19A-6    NVDQEAQKHLWDIYNSDQYVSYPDDDLQVASTVVDVSNGKVIAQLGARHQASNVSFGTNQ
  EF3030          NVDQEAQKHLWDIYNTDEYVAYPDDELQVASTIVDVSNGKVIAQLGARHQSSNVSFGINQ
                  ***************:*:**:****:******:*****************:****** **
  
  TIGR4           AVETNRDWGSTMKPITDYAPALEYGVYDSTATIVHDEPYNYPGTNTPVYNWDRGYFGNIT
  D39             AVETNRDWGSTMKPITDYAPALEYGVYDSTATIVHDEPYNYPGTNTPVYNWDRGYFGNIT
  D39V            AVETNRDWGSTMKPITDYAPALEYGVYDSTATIVHDEPYNYPGTNTPVYNWDRGYFGNIT
  Hungary19A-6    AVETNRDWGSTMKPITDYAPAIEYGVYDSTATMVNDIPYNYPGTSTPVYNWDRAYFGNIT
  EF3030          AVETNRDWGSTMKPITDYAPALEYGVYDSTATIVHDEPYNYPGTNTPVYNWDRGYFGNIT
                  *********************:**********:*:* *******.********.******
  
  TIGR4           LQYALQQSRNVPAVETLNKVGLNRAKTFLNGLGIDYPSIHYSNAISSNTTESDKKYGASS
  D39             LQYALQQSRNVPAVETLNKVGLNRAKTFLNGLGIDYPSIHYSNAISSNTTESDKKYGASS
  D39V            LQYALQQSRNVPAVETLNKVGLNRAKTFLNGLGIDYPSIHYSNAISSNTTESDKKYGASS
  Hungary19A-6    LQYALQQSRNVPAVETLNKVGLDRAKSFLNGLGIDYPVMHYSNAISSNTTESSKQYGASS
  EF3030          LQYALQQSRNVPAVETLNKVGLNRAKTFLNGLGIDYPSIHYSNAISSNTTESDKKYGASS
                  **********************:***:********** :*************.*:*****
  
  TIGR4           EKMAAAYAAFANGGTYYKPMYIHKVVFSDGSEKEFSNVGTRAMKETTAYMMTDMMKTVLT
  D39             EKMAAAYAAFANGGTYYKPMYIHKVVFSDGSEKEFSNVGTRAMKETTAYMMTDMMKTVLS
  D39V            EKMAAAYAAFANGGTYYKPMYIHKVVFSDGSEKEFSNVGTRAMKETTAYMMTDMMKTVLS
  Hungary19A-6    EKMATAYAAFANGGIYHKPMYINKVVFSDGSEKEFSDPGTRAMKETTAYMMTEMMKTVWT
  EF3030          EKMAAAYAAFANGGTYYKPMYIHKVVFSDGSEKEFSNVGTRAMKETTAYMMTDMMKTVLT
                  ****:********* *:*****:*************: **************:***** :
  
  TIGR4           YGTGRNAYLAWLPQAGKTGTSNYTDEEIENHIKTSQFVAPDELFAGYTRKYSMAVWTGYS
  D39             YGTGRNAYLAWLPQAGKTGTSNYTDEEIENHIKTSQFVAPDELFAGYTRKYSMAVWTGYS
  D39V            YGTGRNAYLAWLPQAGKTGTSNYTDEEIENHIKTSQFVAPDELFAGYTRKYSMAVWTGYS
  Hungary19A-6    YGTGRGAYLPWLPQAGKTGTSNYTDEEIEKYIKNTGYVAPDEMFVGYTRKYSMAVWTGYT
  EF3030          YGTGRNAYLAWLPQAGKTGTSNYTDEEIENHIKTSQFVAPDELFAGYTRKYSMAVWTGYS
                  *****.***.*******************::**.: :*****:*.**************:
  
  TIGR4           NRLTPLVGNGLTVAAKVYRSMMTYLSEGSNPEDWNIPEGLYRNGEFVFKNGARSTWNSPA
  D39             NRLTPLVGNGLTVAAKVYRSMMTYLSEGSNPEDWNIPEGLYRNGEFVFKNGARSTWSSPA
  D39V            NRLTPLVGNGLTVAAKVYRSMMTYLSEGSNPEDWNIPEGLYRNGEFVFKNGARSTWSSPA
  Hungary19A-6    NRLTPVVGDGLTVAAKVYRAMITYLSEDDQPGDWTMPDGLYRNGEFVFKNGARSTWNSPA
  EF3030          NRLTPLVGNGLTVAAKVYRSMMTYLSEGSNPEDWNIPEGLYRNGEFVFKNGARSTWSSPA
                  *****:**:**********:*:*****..:* **.:*:******************.***
  
  TIGR4           PQQPPSTESSSSSSDSSTSQSSSTTPSTNNSTTTNPNNNTQQSNTTPDQQNQNPQPAQP
  D39             PQQPPSTESSSSSSDSSTSQSSSTTPSTNNSTTTNPNNNTQQSNTTPDQQNQNPQPAQP
  D39V            PQQPPSTESSSSSSDSSTSQSSSTTPSTNNSTTTNPNNNTQQSNTTPDQQNQNPQPAQP
  Hungary19A-6    PQQPPSTESSSSSSDSSTSQSSSTTPSTNNSTTTNPNNNTQQSNTTPDQQNQNPQPAQP
  EF3030          PQQPPSTESSSSSSDSSTSQSNSTTPSTNNSTTTNPNNNTQQSNTTPDQQNQNPQPAQP
                  *********************.*************************************