PangenomeTIGR4

serotype 4

D39

serotype 2

D39V

serotype 2

Hungary19A-6

serotype 19A

EF3030

serotype 19F

670-6B

serotype 6B

6A-10

serotype 6A

70585

serotype 5

A026

serotype 19F

A66

serotype 3

AP200

serotype 11A

ASP0581

serotype 12F

ATCC 49619

serotype 19F

ATCC 700669

serotype 23F

BVJ1JL

serotype 1

CGSP14

serotype 14

G54

serotype 19F

HU-OH

serotype 3

Hu15

serotype 19A

Hu17

serotype 19A

INV104

serotype 1

INV200

serotype 14

JJA

serotype 14

MDRSPN001

serotype 19F

NCTC7466

serotype 2

NU83127

serotype 4

OXC141

serotype 3

P1031

serotype 1

R6

serotype 2

SP49

serotype 19A

SPN032672

serotype 1

SPN034156

serotype 3

SPN034183

serotype 3

SPN994038

serotype 3

SPN994039

serotype 3

SPNA45

serotype 3

ST556

serotype 19F

TCH8431/19A

serotype 19A

Taiwan19F-14

serotype 19F

Xen35

serotype 4

gamPNI0373

serotype 1

⊟Summary

• pan ID^?: PNEUPAN001606000
• symbol^?: zmpB
• synonym:
• description^?: G5 domain-containing protein

  descriptions from strain specific annotations:

  • G5 domain-containing protein
  • zinc metalloprotease ZmpB
  • LPXTG cell wall anchor domain-containing protein
  • putative zinc metalloproteinase ZmpB
  • Immunoglobulin A1 protease
  • Zinc metalloprotease
  • FIVAR domain-containing protein
  • Zinc metalloprotease ZmpB precursor
  • LPXTG cell wall anchor domain protein
  • LPXTG-motif cell wall anchor domain protein
  • peptidase M26
  • putative IgA-specific zinc metalloproteinase ZmpB
  • Zinc metalloprotease B
  • Zinc metalloprotease B (pseudogene)
  • zinc metalloprotease ZmpB, putative
  • pseudogene
• strand^?: +
• coordinates^?: 1952808..1960064
• occurrence^?: in 98% of 41 strains

⊟Orthologs

TIGR4:
SP_RS03260
D39:
SPD_RS03120 (zmpB)
D39V:
SPV_RS03115 (zmpB)
Hungary19A-6:
SPH_RS03685
EF3030:
EF3030_RS03125
670-6B:
SP670_RS03610
6A-10:
HKM25_RS03160
70585:
SP70585_RS03550
A026:
T308_RS03165
A66:
A66_RS03015
AP200:
SPAP_RS03230
ASP0581:
EL334_RS03330
ATCC 49619:
EL263_RS03280
ATCC 700669:
SPN23F_RS03065
BVJ1JL:
JN057_RS03280
CGSP14:
SPCG_RS03260
G54:
SPG_RS03070
gamPNI0373:
HMPREF1038_RS03395
HU-OH:
EL271_RS03075
Hu15:
SPNHU15_RS03345
Hu17:
SPNHU17_RS03285
INV104:
INV104_RS03260
INV200:
SPNINV200_RS03135
JJA:
SPJ_RS03080
MDRSPN001:
—
NCTC7466:
DQM66_RS03120 (zmpB)
NU83127:
EL277_RS03360
OXC141:
SPNOXC_RS03260
P1031:
SPP_RS03340
R6:
SPR_RS02945 (zmpB)
SP49:
BMJ42_RS03850
SPN032672:
SPN032672_RS09520
SPN034156:
SPN034156_RS09185
SPN034183:
SPN034183_RS03275
SPN994038:
SPN994038_RS03195
SPN994039:
SPN994039_RS03195
SPNA45:
SPNA45_RS05645
ST556:
MYY_RS03645
Taiwan19F-14:
SPT_RS03425
TCH8431/19A:
HMPREF0837_RS04595
Xen35:
CXP32_RS03335

⊟Genome Viewer

TIGR4
D39
D39V
Hungary19A-6
EF3030

⊟Alignments

• alignment of orthologues:
  CLUSTAL format alignment by MAFFT L-INS-i (v7.505)
  
  
  TIGR4           MFKKDRFSIRKIKGVVGSVFLGSLLMAPSVVDAATYHYVNKEIISQEAKDLIQTGKPDRN
  D39             MFKKDRFSIRKIKGVVGSVFLGSLLMAPSVVDAATYHYVNKEIISQEAKDLIQTGKPDRN
  D39V            MFKKDRFSIRKIKGVVGSVFLGSLLMAPSVVDAATYHYVNKEIISQEAKDLIQTGKPDRN
  Hungary19A-6    MFKKDRFSIRKIKGVVGSVFLGSLLMAPSVVDAATYHYVNKEIISQEAKDLIQTGKPDRN
  EF3030          MFKKDRFSIRKIKGVVGSVFLGSLLMAPSVVDAATYHYVNKEIISQEAKDLIQTGKPDRN
                  ************************************************************
  
  TIGR4           EVVYGLVYQKDQLPQTGTEASVLTAFGLLTVGSLLLIYKRKKIASVFLVGAMGLVVLPSA
  D39             EVVYGLVYQKDQLPQTGTEASVLTAFGLLTVGSLLLIYKRKKIASVFLVGTMGLVVLPSA
  D39V            EVVYGLVYQKDQLPQTGTEASVLTAFGLLTVGSLLLIYKRKKIASVFLVGTMGLVVLPSA
  Hungary19A-6    EVVYGLVYQKDQLPQTGTEASVLTAFGLLTVGSLLLIYKRKKIASVFLVGAMGLVVLPSA
  EF3030          EVVYGLVYQKDQLPQTGTEASVLTAFGLLTVGSLLLIYKRKKIASVFLVGAMGLVVLPSA
                  **************************************************:*********
  
  TIGR4           GAVDPVATLALASREGVVEMEGYRYVGYLSGDILKTLGLDTVLEETSAKPGEVTVVEVET
  D39             GAVDPVATLALASREGVVEMEGYRYVGYLSGDILKTLGLDTVLEETSAKPGEVTVVEVET
  D39V            GAVDPVATLALASREGVVEMEGYRYVGYLSGDILKTLGLDTVLEETSAKPGEVTVVEVET
  Hungary19A-6    GAVDPVATLALASREGVVEMDGYRYVGYLSGDILKTLGLDTVLEETSAKPGEVTVVEVET
  EF3030          EAVDPVATLALASREGVVEMDGYRYVGYLSGDILKTLGLDTVLEETSAKPGEVTVVEVET
                   *******************:***************************************
  
  TIGR4           PQSITNQEQARTENQVVETEEAPKEEAPKTEESPKEEPKSEVKPTDDTLPKVEEGKEDSA
  D39             PQSTTNQEQARTENQVVETEEAPKEEAPKTEESPKEEPKSEVKPTDDTLPKVEEGKEDSA
  D39V            PQSTTNQEQARTENQVVETEEAPKEEAPKTEESPKEEPKSEVKPTDDTLPKVEEGKEDSA
  Hungary19A-6    PQSTTNQEQARTENQVVETEEAPKEEAPRTEESPKEEPKSEVKPTDDTLPKVEEGKEDSA
  EF3030          PQSTTNQEQARTENQVVETEEAPKEEAPKTEESPKEEPKSEVKPTDDTLPKVEEGKEDSA
                  *** ************************:*******************************
  
  TIGR4           EPAPVEEVGGEVESKPEEKVAVKPESQPSDKPAEESKVEQAGE-------PVAPREDEKA
  D39             EPAPVEEVGGEVESKPEEKVAVKPESQPSDKPAEESKVEQAGE-------PVAPRKDEQA
  D39V            EPAPVEEVGGEVESKPEEKVAVKPESQPSDKPAEESKVEQAGE-------PVAPRKDEQA
  Hungary19A-6    EPAPVEEVGGEVESKPEEKVAVKPESQPSDKPAEESKVEPPVEQAKVPEQPVQPTQAEQP
  EF3030          EPAPVEEVGGEVESKSEEKVAVKPESQPSDKPAEESKVEQAGE-------PVAPREDEKA
                  ***************.*********************** . *       ** * : *:.
  
  TIGR4           PVEPE-KQPEAPEEEKAVEETPKQEE----STPDTKAEETVEPKEETVNQSIEQPKVETP
  D39             PVEPE-NQPEAPEEEKAVEETPKQEE----STPDTKAEETVEPKEET-------------
  D39V            PVEPE-NQPEAPEEEKAVEETPKQEE----STPDTKAEETVEPKEET-------------
  Hungary19A-6    STPKESSQQENPKEDRGAEETPKQEDEQPAEAPEIKVEEPVESKEET-------------
  EF3030          PVEPE-KQPEAPEEEKAVEETPKQED----TQP-----EVVETKDEAANQPVEEPKVETP
                  ..  * .* * *:*::..*******:      *     * **.*:*:             
  
  TIGR4           AVEKQTEPTEEPKVEQAGEPVAPREDEQAPTAPVEPEKQPEVPEEEKAVEETPKPEDKIK
  D39             ---KTAKGTQEEGKEG-----------QAPVQEVNPEYKVTTGTVEKSTESELDFTTEVV
  D39V            ---KTAKGTQEEGKEG-----------QAPVQEVNPEYKVTTGTVEKSTESELDFTTEVV
  Hungary19A-6    ---KTAKGTQEEGKEG-----------QAPVQEVNPEYKVTTGTVEKSTESELDFTTEVV
  EF3030          AVEKQTEPTEEPKVEQVGEPVEPREDEKAP---VSPEKQPEAPEEEKTAEETPKQEDKIK
                     * :: *:*   *            :**   *.** :  .   **:.*.  .   :: 
  
  TIGR4           GIGTKEPVDKSELNNQIDKASSVSPTDYSTASYNALGPVLETAKGVYASEPVKQPEVNSE
  D39             PDDTKY-VDEEVVERQGSKGVQVTKTTYETVE------VVETDKVLSTTTEVKTPVVPKV
  D39V            PDDTKY-VDEEVVERQGSKGVQVTKTTYETVE------VVETDKVLSTTTEVKTPVVPKV
  Hungary19A-6    PDDTKY-VDEEVVERQGSKGVQVTKTTYETVE------VVETDKVLSTTTEVKTPVVPKV
  EF3030          GIGTKEPVDKSELNNQIDKASSVSPTDYSTASYNALGPVLETAKGVYASEPVKQPEVNSE
                    .**  **:. ::.* .*. .*: * *.*..      *:** * : ::  ** * * . 
  
  TIGR4           TN--------------------KLKTAIDALNVDKTELNN--TIADAKT-----------
  D39             VK--------------------KGTKP--------VETREEVIPFATKEQED--------
  D39V            VK--------------------KGTKP--------VETREEVIPFATKEQED--------
  Hungary19A-6    VK--------------------KGTKPVEGTA---VETREEVIPFATKEQED--------
  EF3030          TKAEKVAANTDAKQSEVNSETASLKTAISGLNTDKVELENQLKIAQGKTETDFSMESWTV
                  .:                    . ...        .* .:       *            
  
  TIGR4           ----------------------------------------------------KVKEHYSD
  D39             -DTLKRGTRQVAQEGVNGKKQITETYKTIRG-------------------------EKTN
  D39V            -DTLKRGTRQVAQEGVNGKKQITETYKTIRG-------------------------EKTN
  Hungary19A-6    -GTLKRGTRQVAQEGVNGKKQITETYKTIRG-------------------------EKTN
  EF3030          LSTAKNKAQEVKDNGTATQEQINEAEKSLKTALADLSVDKTALGSAIDTATKKNKENYTN
                                                                          . ::
  
  TIGR4           RSWQNLQTEVTKAEKVAANTDAKQSEVNEAVEKLTATIEKLVELSEKPILTLTSTDKKIL
  D39             EAPTVEETVLQAPQ-------------DEIIKKGTKGL-------EKPTLQWANTEKDVL
  D39V            EAPTVEETVLQAPQ-------------DEIIKKGTKGL-------EKPTLQWANTEKDVL
  Hungary19A-6    EAPTVEETVLQAPQ-------------DEIIKKGTKGL-------EKPTLEWVKTDKDVL
  EF3030          QTWAELETVLTAAKSVNTN-ESKQSEVNEAVEKLTATIEKLVELSEKPRLTLSIEKRDI-
                  .:    :* :  .:             :* ::* *  :       *** *     .:.: 
  
  TIGR4           EREAVAKYTLENQNKTKIKSITAELK-KGEEVINTVVLTDDKVTTETISAAFKNLEYYKE
  D39             KKSATASYTLTKPAGVEIKSIKLALKDKDGQLVKEVTVAE-----NNLNATLDKLKYYQG
  D39V            KKSATASYTLTKPAGVEIKSIKLALKDKDGQLVKEVTVAE-----NNLNATLDKLKYYQG
  Hungary19A-6    KKSATASYTLNKPDGVEIKSIKVALKDNTGTVIKEVTVEE-----NNLNVTLDNLKYYQG
  EF3030          DRKVTVTYTLENPANTQIKSITATLK-KGEEVVKDFVLTEENLKTNHLTALFEKLDYYKE
                  .:.....*** :   .:****.  ** :   ::: ..: :     : :.. :.:*.**: 
  
  TIGR4           YTLSTTMIYDRGNGEETETLENQNIQLDLKKVELKNIKRTDLIKYEN-GKETNESLITTI
  D39             YTLSTTMVYDRGEGEETEKLEDKQIQLDLKKVEIKNIKETSLMNVDAEGNETDKSLLSEK
  D39V            YTLSTTMVYDRGEGEETEKLEDKQIQLDLKKVEIKNIKETSLMNVDAEGNETDKSLLSEK
  Hungary19A-6    YTLSTTMVYNRGEGEETETLEDKEVQLDLKKVEIKNIKETSLMSVDDAGVETDKSLLTEK
  EF3030          YTLSTDMVYNRGNDDETESISEELIQLNLKKLELKDIQTVSLMKFED-GQESQVTHLSDK
                  ***** *:*:**:.:***.:.:: :**:***:*:*:*: ..*:. :  * *:: : ::  
  
  TIGR4           PDDKSNYYLKITSNNQKTTLLAVKNIEETTVNGTPVYKVTAIADNLVSRTADNKFEEEYV
  D39             PTDVSQLYLRVTTHDNKVTRLAVSSVEEVVVDGKTLYKVVAKAPDLVQRRADDTLSEEYV
  D39V            PTDVSQLYLRVTTHDNKVTRLAVSSVEEVVVDGKTLYKVVAKAPDLVQRRADDTLSEEYV
  Hungary19A-6    PTDVAPLYLRVTTHDNKVTRLAVDKIEEVEEDGKTLYKVTAKAPDLVQRNADNTLSEEYV
  EF3030          PTDLSKLYLKVTSSTSKDAVLAVSSIEEEIVENKKIFKIHADTPELVVRKKDGSLSKGFD
                  * * :  **::*:  .* : ***..:**   :.. ::*: * : :** *  *..:.: : 
  
  TIGR4           HYIEKPKVHEDNVYYNFKELVEAIQNDPSKEYRLGQSMSARNVVP--NGKSYITKEFTGK
  D39             HYFEKQLPKVNNVYYNFNELVKDMQANPMGEFKLGADLNAVNVKP--AGKAYVMAKFRGT
  D39V            HYFEKQLPKVNNVYYNFNELVKDMQANPMGEFKLGADLNAVNVKP--AGKAYVMAKFRGT
  Hungary19A-6    HYFEKQLPKIGNVYYNFNELITDMQKTPNGEFKLGADLNAVNVPT--PNKSYVTAKFTGK
  EF3030          YYMERVIPHDGDIYYDFKDLISAMTSNPTGTFILGRDISSRNVKPDGNGKSYIKGEFKGK
                  :*:*:   : .::**:*::*:  :   *   : ** .:.: ** .   .*:*:  :* *.
  
  TIGR4           LL-SSEGKQFAITELEHPLFNVITNATINNVNFENVEIERS---GQDNIASLANTMKGSS
  D39             LS-SVENHQYTIHNLERPLFNEAEGATLKNFNLGNVNINMP---WADKVAPIGNMFKKST
  D39V            LS-SVENHQYTIHNLERPLFNEAEGATLKNFNLGNVNINMP---WADKVAPIGNMFKKST
  Hungary19A-6    LY-SEGDKHYTIHNLARPLFAQAENAHIHDINLGNVNINMP---WANKTAPLGEMFKKST
  EF3030          LLGTNDNVRHSIFDLEYPLFDTIKSGVVKDIDFKHVNMVFPDSNQGDNVATIARVIKDKT
                  *  :  . :.:* :*  ***    .. :::.:: :*::  .     :: *.:.. :* .:
  
  TIGR4           VITNVKITGTLSGRNNVAGFVNNMNDGTRIENVAFFGKLHSTSGNGSHTGGIAGTNYRGI
  D39             -LENIKVVGSVTGNNDVTGAVNKL-DEANMRNVAFIGKINSLGDKGWWSGGLVSESWRSN
  D39V            -LENIKVVGSVTGNNDVTGAVNKL-DEANMRNVAFIGKINSLGDKGWWSGGLVSESWRSN
  Hungary19A-6    -IENVKVTGNVVGNNDVTGMVNKL-DESDMRNVAFIGNITSVGSAGWWSGGLVSESWRSN
  EF3030          KIENVNVEGYLEGRDHVAGLVNNLEGNSEIENISFTGKIKSKGGN-SITAGIAGRNILSR
                   : *::: * : *.:.*:* **:: . : :.*::* *:: * ..    :.*:.. .  . 
  
  TIGR4           VRKAYVDATITGNKTRASLLVPKVD-YGLTLDHLIGTKALLTESVVKGKIDVSNPVEVGA
  D39             TDSVYFDGDIVGNNSKFGGLVAKVN-HGSN-QWDVKQKGRLTNSVVKGTMTLKNHGQSGG
  D39V            TDSVYFDGDIVGNNSKFGGLVAKVN-HGSN-QWDVKQKGRLTNSVVKGTMTLKNHGQSGG
  Hungary19A-6    TDNSYIDTTIKGNKAKVGGLIAKLN-HGAD-PRDVGARGRLKNSVAKGTIDVRDPQETGG
  EF3030          VKRAYVNANIEVLGSTNSSMLVAVNGTTLNASGGWGAWGRLTESVAKGTLEIKRSGQAGG
                  .   *.:  *    :  . ::  ::             . *.:**.**.: :    : *.
  
  TIGR4           IASKTWPVGTVSNSVSYAKIIR-GEELFGSNDVDDSDYA-SAHIK-DLYAVEGYSSGNRS
  D39             LVHENYDWGWVENNISMMKVNN-GEIMYGSGSIDGDPYFGFDYFK-NNYYVKDVATGEST
  D39V            LVHENYDWGWVENNISMMKVNN-GEIMYGSGSIDGDPYFGFDYFK-NNYYVKDVATGEST
  Hungary19A-6    LLHSNWSWGLAENNITMMKVKNGGEILYGSRDAEDDDYFGANWVRNNNAFVNGISEGKQS
  EF3030          VTATVWPYGAIDKVVSYAKVTK-GKELFGSDGDLNNNWF-MQKIN-NIFGVQGISSGDSG
                  :    :  *  .: ::  *: . *: ::** .  .. :     .. :   *:. : *.  
  
  TIGR4           FRKSKTFTKLTKEQADAKVTTFNITADKLESDLSPLA-KLNE----EKAYSSIQDYNAEY
  D39             YKRSKQIQSISQAEADAKIANMGITANTFAIQ-DPVVNKLNRIIDRDSEYKAIQDYQETR
  D39V            YKRSKQIQSISQAEADAKIANMGITANTFAIQ-DPVVNKLNRIIDRDSEYKAIQDYQETR
  Hungary19A-6    YSRSSRWKGISEDEAKTRIAKMGITAHEYEIT-QHLTDKLNRAAFKEDTYKTTQDYKTER
  EF3030          --NDSKFKRISEEEAKQKVASYNITAPNLMSDSSLLVDRLNESWKNTDQFESIQDYQSQN
                    ...    ::: :*. :::. .***       . :. :**.     . :.: ***:   
  
  TIGR4           NQAYKNLEKLIPFYNKDYIVYQGNKLNKEHH-LNTKEVLSVTAMNNNEFITNLDEANKII
  D39             NLAYRNLEKLQPFYNKEWIVNQGNKLTDESN-LVKKTVLSVTGMKSGQFVTDLSSVDKIM
  D39V            NLAYRNLEKLQPFYNKEWIVNQGNKLTDESN-LVKKTVLSVTGMKSGQFVTDLSSVDKIM
  Hungary19A-6    ELAYRNIEKLQPFYNKEWIINQGNKLTDGSN-LMIKEVLSVIGMKNGQFVTDLSDIDKIM
  EF3030          QLIYQNLTKFTPYYNKEFIVHEGNALTPEQEILKTKKIKSIVGLKGTEFVVDGSDIDTIM
                  :  *:*: *: *:***::*: :** *.   . *  * : *: .::. :*:.: .. :.*:
  
  TIGR4           VHYADGTKDYFNLSSSSEG-LSNVKEYTITDLG-IKYTP-NIVQKDNTTLVNDIKSILES
  D39             IHYADGTKEEFGVSAISDSRVKQVKEYNVDDLG-VVYTP-NMVDKNRDSLITKVKEKLSS
  D39V            IHYADGTKEEFGVSAISDSRVKQVKEYNVDDLG-VVYTP-NMVDKNRDSLITKVKEKLSS
  Hungary19A-6    IHYADGTKEEKTVTRKADSKVQQIREYSVEGLGDVVYTP-NMVEKDRAQLITDIKAKLDS
  EF3030          LHFEDGSQKRYKVTSTGKFSITNLPEYQVEDLN-VVYTSEHIVHPLDSSLINNLVEELKK
                  :*: **::.   ::  ..  : :: ** : .*. : **. ::*.     *:..:   *..
  
  TIGR4           VELQSQTMYQHL--NRLGDYRVNA-------IKDLYLEESFTDVKENLTNLITKLVQNEE
  D39             VALDSAEVKSIT--NNPA---------------SLYLEESFAEVRETLDKLVKSLLENED
  D39V            VALDSAEVKSIT--NNPA---------------SLYLEESFAEVRETLDKLVKSLLENED
  Hungary19A-6    VQLISPEVRNLM--DKRGKAHENTDERRNGYIRNLFLEESLDEVKGNLDKLVKALVENED
  EF3030          VELYTESTYQVLGIDKDNANKLNR-------TKRLFLDESLDAVKTQLPTFVKTMFENEW
                  * * :    .    :.                  *:*:**:  *:  * .::. :.:** 
  
  TIGR4           HQLNDSPA-ARQMIRDKVEKNKAALLLGLTYLNRYYGVKFGDVNIKELMLFKPDFYGEKV
  D39             HQLNSDEV-AEKALLKKVEDNKAKIILALTYLNRYYGIDYDGLNFKHLMMFKPDFYGKTP
  D39V            HQLNSDEV-AEKALLKKVEDNKAKIILALTYLNRYYGIDYDGLNFKHLMMFKPDFYGKTP
  Hungary19A-6    HQLNGDEA-AMKALVKKVEDNKAKIMLGLAYLNRYYGFKYDEKSMKDIMMFKPDFYGKNV
  EF3030          LHINGESSGAVAALRQKIMDNKTAILLALTYINRYYDVKFSDYNIKKLMLFKPTFHGEKI
                   ::*..   *   : .*: .**: ::*.*:*:****...:.  .:*.:*:*** *:*:. 
  
  TIGR4           SVLDRLIEIGSK-ENNIKGSRTFDAFGQVLAKYTKSGNLDAFLNYNRQLFTNIDNMNDWF
  D39             SILDFLIRIGSA-EKNLKGDRSLEAYREVIGGTIGKGELNGLLGYNMRLFTKYTDLNDWF
  D39V            SILDFLIRIGSA-EKNLKGDRSLEAYREVIGGTIGKGELNGLLGYNMRLFTKYTDLNDWF
  Hungary19A-6    SVLDFLIRVGSR-EHNIKGNRTLEAYREVIGGTIGIGELNGFLNYNMRLFTEETDINTWY
  EF3030          DLLDRLIRLGSSGENRLKGSENAETFKQLFASETKQKDLVTYLDYNRSLLTNYQTTGEWF
                  .:** **.:**  *:.:**... ::: :::.      :*   *.**  *:*:    . *:
  
  TIGR4           IDATEDHVYIAERASEVEEIKNSKHRAFDNLKRSHLRNTILPLLNIDKAHLYLISNYNAI
  D39             IHAAKNV-YVSEPETTTEDFKDKRHRIYDGLNNDVHGRMILPLLNLKKAHIFVISTYNTI
  D39V            IHAAKNV-YVSEPETTTEDFKDKRHRIYDGLNNDVHGRMILPLLNLKKAHIFVISTYNTI
  Hungary19A-6    KKAVSHTNYIVEKQSSNPAFANKKYRLYENLNNGEHGKYILPLLTTKKAHMFLISTYNTL
  EF3030          KETTKDYIQFEERPSLVEEIKDAKYRVYDNLTAPYYQGYILPLLTLKNTHLAILSNYSTM
                   .:...   . *  :    : : ::* ::.*.       *****. .::*: ::*.*.::
  
  TIGR4           AFGSAERLGKKSLED---IKDIVNKAADGYRNYYDFWYRLASDNVKQRLLRDA---VIPI
  D39             AFSSFEKYGKNTEEERNAYKAEIDRVAKAQQRYLDFWSRLALPKVRNQLLKSQNSVPTPV
  D39V            AFSSFEKYGKNTEEERNAYKAEIDRVAKAQQRYLDFWSRLALPKVRNQLLKSQNSVPTPV
  Hungary19A-6    AFSAFEKYGKNTEAEREAFKKEIDLRAQEQINYLDFWSRLAADNVRDRLLKSENMVPSAI
  EF3030          TFVSREKRPNWKNED---FDKWVKYVATAHRNHVDTWYKILPDNIKGKMVKEN---VTAV
                  :* : *:  : .  :    .  :.  *    .: * * ::   ::: ::::.      .:
  
  TIGR4           WEGYNAPG-GWVEKYGRYNTDKVYTPLREFF----GPMDKYYNYN-GTGAYAAIYPNSDD
  D39             WDNQVYVGLGGANRMGYGDGGRVVTPVRELF----GPTDRWHQINWNMGAMAKIYERP-W
  D39V            WDNQVYVGLGGANRMGYGDGGRVVTPVRELF----GPTDRWHQINWNMGAMAKIYERP-W
  Hungary19A-6    WDNQEVPGHGWADRMGHNKNGD-YAPVREFY----GPTGKWHGYN-GTGAYAYIFTNP-Q
  EF3030          WEGLSIPGSEWVDQNAVDRKGRDYAPAREFFNLVGGPMGGWYAYH-GYGAHA-------G
                  *:.    *   .:: .    .   :* **::    ** . ::  : . ** *        
  
  TIGR4           IRTDVKYVHLEMVGEYGISVYTHETTHVNDRAIYLGGFGHREGTDAEAYAQGMLQTPVTG
  D39             KDDQVYFMVTNMMEPFGISAFTHETTHVNDRMAYYGGDWHREGTDLEAFAQGMLQTPDKS
  D39V            KDDQVYFMVTNMMEPFGISAFTHETTHVNDRMAYYGGDWHREGTDLEAFAQGMLQTPDKS
  Hungary19A-6    NSEAVYYIISSMISDFGTSAFTHETTHINDRMAYLGGWRHREGTDVEAFAQGMLQSPAVS
  EF3030          GRNRVNYEVFDVLSEYGISVFTHELTHVNDTWIYLGGYGRRENMGPEAYAQGLFQSPVPG
                      * :   .::  :* *.:*** **:**   * **  :**. . **:***::*:*  .
  
  TIGR4           SGFDEFGSLGINMVFKRKNDGNQWYITDPKTLKTREDINRYMKGYNDTLTLLDEIEAESV
  D39             TTNGEYGALGINMAYERKNDGEQLYNYDPEKLDSREKIDSYMKNYNESMMMLDYLEASAV
  D39V            TTNGEYGALGINMAYERKNDGEQLYNYDPEKLDSREKIDSYMKNYNESMMMLDYLEASAV
  Hungary19A-6    SPNGDYGALGLNMAYKRENDGNQWYNYDSNKLDSRAKIDHYMKNYNEALMMLDHLEADAV
  EF3030          QPG--WGALGLNMAFERKNDGDLIYNASPTQFENRKELDSYMKNYNDTLMMVDYLEGDAV
                       :*:**:**.::*:***:  *  ..  :..* .:: ***.**::: ::* :*..:*
  
  TIGR4           ISQQNKDLNSAWFKKIDREYRDNNKLN-------QWDKIRNLSQEEKNELNIQSVNDLVD
  D39             IRQNLSD-NSKWFKKMDKEWRTNADRNRLIGEPHQWDKLRDLTEEEK-KLPIDSIDKLVE
  D39V            IRQNLSD-NSKWFKKMDKEWRTNADRNRLIGEPHQWDKLRDLTEEEK-KLPIDSIDKLVE
  Hungary19A-6    IAKNNGD-NNKWFKKMDKKWRENANRNGLVGQPHQWDLLRDLNEEEN-KKKLTSIDDLVD
  EF3030          ISKGKEA-ITKWFKKVEPK---------VVSQTAQYDTVRQLTAEEKEKLSVSSVDDLVD
                  * :      . ****:: :               *:* :*:*. **: :  : *::.**:
  
  TIGR4           QQLMTNRN-PGNGIYKPEAISYNDQSPYVGVRMMTGIY-GGNTSKGAPGAVSFKHNAFRL
  D39             NNFVTLHGMPKNGRYRTEGF----DSSYQPVNMMAGVF-GGNTSKSTVGSISFKHNAFRM
  D39V            NNFVTLHGMPKNGRYRTEGF----DSSYQPVNMMAGVF-GGNTSKSTVGSISFKHNAFRM
  Hungary19A-6    GNYVTKHNMPGNKHYRAEGF----DTAYQTVNMMAGIY-GGNTSKSAVGSISFKHNTFRM
  EF3030          QGLMSDRA-VGNNTYNPADF----ETSYIAIDYMTGIYGGGKNSVGSPGALMFKHNTFRM
                     :: :    *  *..  :    ::.*  :  *:*:: **:.* .: *:: ****:**:
  
  TIGR4           WGYYGYENGFLGYASNKYKQQSKTDGESVLSDEYIIKKISNNTFNTIEEFKKAYFKEVKD
  D39             WGYYGYENGFIPYVSNKLKGAANKENKGLLGDDFIIKKVSKNQFQNLEEWKKHWYHEVYD
  D39V            WGYYGYENGFIPYVSNKLKGAANKENKGLLGDDFIIKKVSKNQFQNLEEWKKHWYHEVYD
  Hungary19A-6    WGYFGYLDGFVGYASNKYKDAANKENKGLLGDDFIIKKVSDGKFDSLEAWKKEWFKEVKA
  EF3030          WGYYGFEEGVLGYASNKFKQASRDEGHAGLSDNFIISKISKGEFLTMEAFKKGYFKKVVE
                  ***:*: :*.: *.*** *  :. :... *.*::**.*:*.. * .:* :** ::::*  
  
  TIGR4           K-ATKGLTTFEVNGSSVSSYDDLLTLFKEAVKKDAETLKQEANGNKTVSMNNTVKLKEAV
  D39             K-AQKGFVEIEVDGVKISTYAQLQSLFEEAVSKDLAGMDDK---NIKNHYQYTENLKWKI
  D39V            K-AQKGFVEIEVDGVKISTYAQLQSLFEEAVSKDLAGMDDK---NIKNHYQYTENLKWKI
  Hungary19A-6    K-GEKGFVAIEIDGKTITNYAELRELFDKAVEADLKAGNSN----------QTVALKEKV
  EF3030          ELKTKGIRPVTINQKTYSTFEELQEGFKQAVERDLK--------KNQLDERETRNFKFQV
                  :   **:  . ::  . :.: :*   *.:**. *                  *  :*  :
  
  TIGR4           YKKLLQQTNSFKTSIFK----
  D39             YKQLLKNTDGFSSDLFTAPQA
  D39V            YKQLLKNTDGFSSDLFTAPQA
  Hungary19A-6    YKQLLQKSDGFVGNLFKA---
  EF3030          FRQLLQQTDSFKTSIFR----
                  :::**::::.*  .:*