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serotype 4
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serotype 2
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serotype 6B
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70585
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Hu17
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serotype 1
NCTC7466
serotype 2
NU83127
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OXC141
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SP49
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SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 31-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae 670-6B
  • locus tag: SP670_0789 [new locus tag: SP670_RS03925 ]
  • pan locus tag?: PNEUPAN001677000
  • symbol: SP670_0789
  • pan gene symbol?: mta
  • synonym:
  • product: regulator of the multidrug efflux pump PmrA

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SP670_0789 [new locus tag: SP670_RS03925 ]
  • symbol: SP670_0789
  • product: regulator of the multidrug efflux pump PmrA
  • replicon: chromosome
  • strand: +
  • coordinates: 742823..743434
  • length: 612
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    TTGGAACGCCTTCAGGTCATTCTTTACTACAAATATCTAGGCTTTTCTTTAGAGAAAATA
    GCAGAGCTGTTAAAGGAAGAAAGGACAGATTTATTGCCCCATTTGACTAGGCAGTTGGAC
    TATCTAACTCGCGAAAGGCAACATCTGGATACCTTGATTTCCACCTTGCAAAAAACTATT
    CAAGAACAAAAAGGAGAAAGAAAAATGACCATTGAGGAAAAATTCACGGGATTTAGCTAT
    CAAGACAATCAAAAATACCACCAAGAAGCGGTAGAGAAATATGGTCAAGAAGTCATGGGA
    CAAGCGCTCGAACGCCAAAAAGGTCACGAAGACGAGGCTACGGCCGCCTTTAACCAAGTC
    TTTCAAACTTTGGCACAAAATCTTCAAGTTGGTTTACCTGCAACAGCAACCGAAAACCAG
    GAGCAAGCAGCCAAGCTCTTGCAAGCTATTCGCACTTATGGATTTGACTGCTCTATTGAG
    GTATTCGGTCATATCGGTAAAGGTTACGTCTACAACCCAGAGTTTAAGAAAAACATTGAC
    AAGTTTGGTTCTGGAACAGCCCAGTACACGTCAGATGCCATTGCGGCTTACGTTCAGACA
    AATGCAGAATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    612

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SP670_0789 [new locus tag: SP670_RS03925 ]
  • symbol: SP670_0789
  • description: regulator of the multidrug efflux pump PmrA
  • length: 203
  • theoretical pI: 5.37066
  • theoretical MW: 23346
  • GRAVY: -0.655172

⊟Function[edit | edit source]

  • TIGRFAM:
    Signal transduction Regulatory functions DNA interactions Zn(II)-responsive transcriptional regulator (TIGR02043; HMM-score: 13.5)
    Cellular processes Cellular processes Detoxification Hg(II)-responsive transcriptional regulator (TIGR02051; HMM-score: 12.7)
    Signal transduction Regulatory functions DNA interactions Hg(II)-responsive transcriptional regulator (TIGR02051; HMM-score: 12.7)
    4-nitrotryptophan synthase (TIGR04458; EC 1.-.-.-; HMM-score: 12.4)
  • TheSEED  :
    • Regulator of the multidrug efflux pump pmrA
  • PFAM:
    no clan defined TipAS; TipAS antibiotic-recognition domain (PF07739; HMM-score: 77.7)
    and 6 more
    HTH (CL0123) MerR-DNA-bind; MerR, DNA binding (PF09278; HMM-score: 36.8)
    no clan defined Enkurin; Calmodulin-binding (PF13864; HMM-score: 14.8)
    4H_Cytokine (CL0053) IL5; Interleukin 5 (PF02025; HMM-score: 12.8)
    DNA_primase_lrg (CL0242) DNA_primase_lrg; Eukaryotic and archaeal DNA primase, large subunit (PF04104; HMM-score: 12.1)
    no clan defined DUF2203; Uncharacterized conserved protein (DUF2203) (PF09969; HMM-score: 11.1)
    STAT_int; STAT protein, protein interaction domain (PF02865; HMM-score: 10.8)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9946
    • Cytoplasmic Membrane Score: 0.0008
    • Cell wall & surface Score: 0.0004
    • Extracellular Score: 0.0042
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.002704
    • TAT(Tat/SPI): 0.000268
    • LIPO(Sec/SPII): 0.000355
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: ADM90856 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MERLQVILYYKYLGFSLEKIAELLKEERTDLLPHLTRQLDYLTRERQHLDTLISTLQKTIQEQKGERKMTIEEKFTGFSYQDNQKYHQEAVEKYGQEVMGQALERQKGHEDEATAAFNQVFQTLAQNLQVGLPATATENQEQAAKLLQAIRTYGFDCSIEVFGHIGKGYVYNPEFKKNIDKFGSGTAQYTSDAIAAYVQTNAE

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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